Protein: SESN2
Sestrin-2 (EC 1.11.1.-) (Hypoxia-induced gene)

Gene: SESN2
Organism: Homo sapiens
Interactions: 40
UniProt ID: P58004

Gene Ontology (top 5):
GO:0001932 - regulation of protein phosphorylation
GO:0004601 - peroxidase activity
GO:0005092 - GDP-dissociation inhibitor activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

945680

WDR24
GATOR2 complex protein WDR24

7

6

Small-scale

0.752

High

945684

MIOS
GATOR2 complex protein MIOS

5

5

Small-scale

0.723

High

945672

WDR59
GATOR2 complex protein WDR59

4

6

Small-scale

0.708

High

945659

WDR5
WD repeat-containing protein 5

5

0

High-throughput

0.686

High

945665

SQSTM
Sequestosome-1

3

2

Small-scale

0.675

High

938197

SEC13
Protein SEC13 homolog

3

1

High-throughput

0.667

High

279137

ULK1
Serine/threonine-protein kinase ULK1

2

1

Small-scale

0.639

High

945664

NPRL3
GATOR1 complex protein NPRL3

2

1

Small-scale

0.634

High

945660

RBX1
E3 ubiquitin-protein ligase RBX1

2

1

Small-scale

0.611

High

945683

RN167
E3 ubiquitin-protein ligase RNF167

1

0

Small-scale

0.554

High

945658

SESN2
Sestrin-2

1

0

Small-scale

0.546

High

945679

STALP
AMSH-like protease

1

0

Small-scale

0.537

High

945667

KEAP1
Kelch-like ECH-associated protein 1

1

1

Small-scale

0.536

High

945668

RBBP5
Retinoblastoma-binding protein 5

1

1

High-throughput

0.536

High

271460

ATG13
Autophagy-related protein 13

1

0

Small-scale

0.513

High

388177

GLPA
Glycophorin-A

1

0

High-throughput

0.513

High

945670

SZT2
KICSTOR complex protein SZT2

1

0

Small-scale

0.513

High

945675

RBCC1
RB1-inducible coiled-coil protein 1

1

0

Small-scale

0.513

High

945676

NPRL2
GATOR1 complex protein NPRL2

1

0

Small-scale

0.513

High

384393

CRYAA
Alpha-crystallin A chain

1

0

High-throughput

0.480

High

945662

PRDX1
Peroxiredoxin-1

1

1

Small-scale

0.479

High

945682

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.479

High

945661

MDM2
E3 ubiquitin-protein ligase Mdm2

1

0

High-throughput

0.460

High

271349

DEPD5
GATOR1 complex protein DEPDC5

1

0

Small-scale

0.458

High

363056

EGFR
Epidermal growth factor receptor

1

0

High-throughput

0.458

High

588339

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

695068

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

896959

MAP2
Methionine aminopeptidase 2

1

0

Small-scale

0.458

High

934350

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.458

High

945663

EP300
Histone acetyltransferase p300

1

0

High-throughput

0.458

High

945666

CUL4A
Cullin-4A

1

0

High-throughput

0.458

High

945673

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

945674

ATG9A
Autophagy-related protein 9A

1

0

High-throughput

0.458

High

945677

CAST1
Cytosolic arginine sensor for mTORC1 subunit 1

1

0

Small-scale

0.458

High

945681

YTHD1
YTH domain-containing family protein 1

1

0

High-throughput

0.458

High

945669

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

945671

DHX57
Putative ATP-dependent RNA helicase DHX57

2

0

High-throughput

0.328

High

945685

RN186
E3 ubiquitin-protein ligase RNF186

1

0

Small-scale

0.261

Low

945678

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025