HitPredict

Interactor 1: DLK1 (P80370)
Protein delta homolog 1 (DLK-1) (pG2) [Cleaved into: Fetal antigen 1 (FA1)]
Gene: DLK1

Interactor 2: EGFL7 (Q9UHF1)
Epidermal growth factor-like protein 7 (EGF-like protein 7) (Multiple epidermal growth factor-like domains protein 7) (Multiple EGF-like domains protein 7) (NOTCH4-like protein) (Vascular endothelial statin) (VE-statin) (Zneu1)
Gene: EGFL7

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	EGF~FXa_inhibition
Common GO terms	GO:0005509 - calcium ion binding GO:0045746 - negative regulation of Notch signaling pathway
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 383 Hs			1 273
+	Hs
		980568 NOTC2_HUMAN (10-316): 6e-28: 118: 23.61		EGFL7_HUMAN (1-273): 1.56e-39: 140: 100.00
+	Hs
		804361 NOTC1_HUMAN (6-314): 3.86e-22: 100: 22.02		EGFL7_HUMAN (1-273): 1.56e-39: 140: 100.00
+	Hs
		804272 DLK2_HUMAN (7-245): 4.55e-50: 174: 41.67		NOTC1_HUMAN (80-168): 1.88e-09: 60.1: 21.81
+	Dm
		247258 TENM_DROME (164-354): 9.9e-24: 105: 12.92		TENA_DROME (13-224): 3.69e-27: 112: 14.04
+	Rn
		250561 CUBN_RAT (2-296): 2.03e-37: 146: 21.18		CUBN_RAT (129-268): 1.23e-11: 66.8: 13.16
+	Dm
		246701 TENM_DROME (164-354): 9.9e-24: 105: 12.92		TENM_DROME (4-250): 1.41e-23: 102: 12.37
+	Dm
		1375758 TENA_DROME (175-354): 7.15e-20: 94: 13.45		TENA_DROME (13-224): 3.69e-27: 112: 14.04
+	Dm
		247183 TENM_DROME (164-354): 9.9e-24: 105: 12.92		Q9VTP0_DROME (6-174): 1.26e-18: 87.6: 17.34
+	Hs
		296652 NOTC2_HUMAN (10-316): 6e-28: 118: 23.61		SLIT2_HUMAN (3-138): 1.42e-12: 69.5: 11.77
+	Dr
		60071 A4JYS0_DANRE (71-351): 7.48e-24: 105: 19.44		A4JYS0_DANRE (41-186): 6.71e-16: 79.1: 23.18
+	Hs
		980413 NOTC2_HUMAN (10-316): 6e-28: 118: 23.61		NPNT_HUMAN (80-173): 1.51e-11: 65.9: 32.35
+	Hs
		944119 NOTC2_HUMAN (10-316): 6e-28: 118: 23.61		JAG1_HUMAN (66-168): 1.68e-10: 63.2: 28.57
+	Hs
		235015 CUBN_HUMAN (162-340): 1.11e-24: 108: 23.20		CUBN_HUMAN (129-272): 6.69e-13: 70.6: 9.40
+	Hs
		804213 NOTC2_HUMAN (10-316): 6e-28: 118: 23.61		NOTC1_HUMAN (80-168): 1.88e-09: 60.1: 21.81
+	Hs
		804198 NOTC1_HUMAN (6-314): 3.86e-22: 100: 22.02		JAG1_HUMAN (66-168): 1.68e-10: 63.2: 28.57
+	Hs
		804163 NOTC1_HUMAN (6-314): 3.86e-22: 100: 22.02		NOTC1_HUMAN (80-168): 1.88e-09: 60.1: 21.81
+	Hs
		132252 DLL1_HUMAN (71-351): 2.84e-19: 91.7: 19.08		NOTC1_HUMAN (80-168): 1.88e-09: 60.1: 21.81
+	Hs
		804379 JAG2_HUMAN (10-244): 2.35e-18: 89: 25.81		NOTC1_HUMAN (80-168): 1.88e-09: 60.1: 21.81
+	Hs
		804372 NOTC3_HUMAN (22-244): 1.94e-17: 86.7: 31.37		NOTC1_HUMAN (80-168): 1.88e-09: 60.1: 21.81