HitPredict

Interactor 1: TNIK (P83510)
Traf2 and NCK-interacting protein kinase (EC 2.7.11.1)
Gene: TNIK

Interactor 2: AGAP2 (Q3UHD9)
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 (AGAP-2) (Centaurin-gamma-1) (Cnt-g1) (Phosphatidylinositol 3-kinase enhancer) (PIKE)
Gene: AGAP2

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28706196, 28671696
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ank_2~Pkinase, Pkinase~Ras
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0030036 - actin cytoskeleton organization GO:0098978 - glutamatergic synapse
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 1323 Mm			1 1186
+	Mm
		90327 E0CZD7_MOUSE (1-1323): 0: 1198: 91.96		AGAP2_MOUSE (1-1186): 0: 1024: 100.00
+	Mm
		1112654 MINK1_MOUSE (1-1323): 0: 1095: 64.51		AGAP2_MOUSE (1-1186): 0: 1024: 100.00
+	Mm
		100217 F7AMS7_MOUSE (148-1323): 0: 898: 59.89		AGAP2_MOUSE (1-1186): 0: 1024: 100.00
+	Mm
		949309 TNIK_MOUSE (1-1323): 0: 1277: 100.00		GIT1_MOUSE (932-1139): 6.25e-72: 258: 32.88
+	Hs
		681996 AKT1_HUMAN (3-358): 1.62e-122: 390: 21.08		AGAP2_HUMAN (1-1147): 0: 987: 94.10
+	Hs
		681853 AKT1_HUMAN (3-358): 1.62e-122: 390: 21.08		ACAP1_HUMAN (614-1104): 5.16e-25: 114: 13.81
+	Dm
		1249831 HIPPO_DROME (1-317): 6.16e-109: 360: 38.89		GIT_DROME (940-1138): 6.61e-22: 104: 32.89