Protein: MYPR
Myelin proteolipid protein (PLP) (Lipophilin)

Gene: MYPR, PLP1
Organism: Homo sapiens
Interactions: 122
UniProt ID: P60201

Gene Ontology (top 5):
GO:0005198 - structural molecule activity
GO:0005886 - plasma membrane
GO:0006954 - inflammatory response
GO:0007268 - chemical synaptic transmission
GO:0008366 - axon ensheathment

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

949246

PTPRN
Receptor-type tyrosine-protein phosphatase-like N

6

0

High-throughput

0.711

High

949272

CR3L1
Cyclic AMP-responsive element-binding protein 3-like protein 1

4

1

High-throughput

0.644

High

194686

FFAR2
Free fatty acid receptor 2

2

3

High-throughput

0.606

High

297341

DYSF
Dysferlin

2

1

High-throughput

0.606

High

590265

MUC1
Mucin-1

2

1

High-throughput

0.606

High

683224

TNR5
Tumor necrosis factor receptor superfamily member 5

2

2

High-throughput

0.606

High

688544

NKG2A
NKG2-A/NKG2-B type II integral membrane protein

2

1

High-throughput

0.606

High

942420

CLD20
Claudin-20

2

1

High-throughput

0.606

High

945177

CLD2
Claudin-2

2

1

High-throughput

0.606

High

949238

STX4
Syntaxin-4

2

4

High-throughput

0.606

High

949244

AAAT
Neutral amino acid transporter B(0)

2

1

High-throughput

0.606

High

949245

STX1A
Syntaxin-1A

2

4

High-throughput

0.606

High

949261

AGRG3
Adhesion G protein-coupled receptor G3

2

3

High-throughput

0.606

High

949274

MS4A3
Membrane-spanning 4-domains subfamily A member 3

2

1

High-throughput

0.606

High

949276

M4A4A
Membrane-spanning 4-domains subfamily A member 4A

2

1

High-throughput

0.606

High

949291

GPR61
G-protein coupled receptor 61

2

2

High-throughput

0.606

High

949304

CLC2D
C-type lectin domain family 2 member D

2

1

High-throughput

0.606

High

127601

HYAS3
Hyaluronan synthase 3

2

0

High-throughput

0.580

High

139201

UPK2
Uroplakin-2

2

0

High-throughput

0.580

High

162183

CDIPT
CDP-diacylglycerol--inositol 3-phosphatidyltransferase

2

0

High-throughput

0.580

High

188850

TMPS2
Transmembrane protease serine 2

2

0

High-throughput

0.580

High

407065

HG2A
HLA class II histocompatibility antigen gamma chain

2

0

High-throughput

0.580

High

818827

TYRP2
L-dopachrome tautomerase

2

0

High-throughput

0.580

High

949235

IFM3
Interferon-induced transmembrane protein 3

2

0

High-throughput

0.580

High

949236

NRG1
Pro-neuregulin-1, membrane-bound isoform

2

0

High-throughput

0.580

High

949247

SOAT
Sodium-dependent organic anion transporter

2

0

High-throughput

0.580

High

949251

SGMR2
Sigma intracellular receptor 2

2

0

High-throughput

0.580

High

949258

TM182
Transmembrane protein 182

2

0

High-throughput

0.580

High

949267

RELL2
RELT-like protein 2

2

0

High-throughput

0.580

High

949268

LHPL5
LHFPL tetraspan subfamily member 5 protein

2

0

High-throughput

0.580

High

949273

S41A3
Solute carrier family 41 member 3

2

0

High-throughput

0.580

High

949277

SUSD3
Sushi domain-containing protein 3

2

0

High-throughput

0.580

High

949279

AQP10
Aquaporin-10

2

0

High-throughput

0.580

High

949281

MYADM
Myeloid-associated differentiation marker

2

0

High-throughput

0.580

High

949289

S26A6
Solute carrier family 26 member 6

2

0

High-throughput

0.580

High

949290

CABP8
Calcium-binding protein 8

2

0

High-throughput

0.580

High

949296

TNR27
Tumor necrosis factor receptor superfamily member 27

2

0

High-throughput

0.580

High

949297

JPH1
Junctophilin-1

2

0

High-throughput

0.580

High

949233

REEP5
Receptor expression-enhancing protein 5

2

1

High-throughput

0.574

High

949275

REEP6
Receptor expression-enhancing protein 6

2

1

High-throughput

0.574

High

388059

MBP
Myelin basic protein

2

0

Small-scale

0.560

High

949278

FCRL2
Fc receptor-like protein 2

2

2

High-throughput

0.553

High

949282

RMD3
Regulator of microtubule dynamics protein 3

2

1

High-throughput

0.553

High

949305

RNF24
RING finger protein 24

2

1

High-throughput

0.553

High

949306

ERGI3
Endoplasmic reticulum-Golgi intermediate compartment protein 3

2

1

High-throughput

0.553

High

529456

TAU
Microtubule-associated protein tau

2

8

Small-scale

0.552

High

421824

A4
Amyloid-beta precursor protein

1

0

Small-scale

0.549

High

373861

RASN
GTPase NRas

1

1

High-throughput

0.536

High

230295

CREB3
Cyclic AMP-responsive element-binding protein 3

1

1

High-throughput

0.523

High

702756

5HT2C
5-hydroxytryptamine receptor 2C

1

0

High-throughput

0.518

High

728139

AKT1
RAC-alpha serine/threonine-protein kinase

1

0

High-throughput

0.518

High

949232

MYPR
Myelin proteolipid protein

1

1

Small-scale

0.515

High

193404

GPR42
G-protein coupled receptor 42

1

4

High-throughput

0.515

High

949243

SLMAP
Sarcolemmal membrane-associated protein

1

0

High-throughput

0.513

High

949307

RN114
E3 ubiquitin-protein ligase RNF114

1

0

High-throughput

0.513

High

949242

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

1

High-throughput

0.494

High

605985

CAN2
Calpain-2 catalytic subunit

1

0

High-throughput

0.493

High

949260

SKAP1
Src kinase-associated phosphoprotein 1

1

0

High-throughput

0.493

High

228563

STRN
Striatin

1

1

High-throughput

0.489

High

949239

TADBP
TAR DNA-binding protein 43

1

1

High-throughput

0.489

High

949285

SIKE1
Suppressor of IKBKE 1

1

1

High-throughput

0.489

High

949299

STRN4
Striatin-4

1

1

High-throughput

0.489

High

949301

FGOP2
FGFR1 oncogene partner 2

1

1

High-throughput

0.489

High

385609

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.460

High

779700

MOT8
Monocarboxylate transporter 8

1

0

High-throughput

0.460

High

870706

CXA8
Gap junction alpha-8 protein

1

0

High-throughput

0.460

High

448006

ITAV
Integrin alpha-V

1

0

Small-scale

0.458

High

612052

ITB5
Integrin beta-5

1

0

Small-scale

0.458

High

697824

CALR
Calreticulin

1

0

Small-scale

0.458

High

404751

PRIO
Major prion protein

1

2

Small-scale

0.445

High

949298

S35C2
Solute carrier family 35 member C2

1

1

High-throughput

0.439

High

949303

CLN8
Protein CLN8

1

1

Small-scale

0.439

High

949308

TRPV2
Transient receptor potential cation channel subfamily V member 2

1

0

Small-scale

0.438

High

105668

APRIO
Alternative prion protein

1

2

High-throughput

0.437

High

949262

SLX4
Structure-specific endonuclease subunit SLX4

1

3

High-throughput

0.437

High

843435

HD
Huntingtin

1

4

High-throughput

0.407

High

949288

B2L13
Bcl-2-like protein 13

3

0

High-throughput

0.348

High

71844

LEUTX
Paired-like homeodomain transcription factor LEUTX

2

0

High-throughput

0.316

High

166893

MGST3
Glutathione S-transferase 3, mitochondrial

2

0

High-throughput

0.316

High

329626

LERL1
Leptin receptor overlapping transcript-like 1

2

0

High-throughput

0.316

High

377852

GAST
Gastrin [Cleaved into: Gastrin-71

2

0

High-throughput

0.316

High

510093

S35E2
Solute carrier family 35 member E2A

2

0

High-throughput

0.316

High

926756

VMAT1
Chromaffin granule amine transporter

2

0

High-throughput

0.316

High

943437

PIGP
Phosphatidylinositol N-acetylglucosaminyltransferase subunit P

2

0

High-throughput

0.316

High

949240

BIK
Bcl-2-interacting killer

2

0

High-throughput

0.316

High

949241

AQP6
Aquaporin-6

2

0

High-throughput

0.316

High

949248

AR13B
ADP-ribosylation factor-like protein 13B

2

0

High-throughput

0.316

High

949249

TM52B
Transmembrane protein 52B

2

0

High-throughput

0.316

High

949252

F209A
Protein FAM209A

2

0

High-throughput

0.316

High

949256

PI16
Peptidase inhibitor 16

2

0

High-throughput

0.316

High

949257

SPNS3
Protein spinster homolog 3

2

0

High-throughput

0.316

High

949259

S35E3
Solute carrier family 35 member E3

2

0

High-throughput

0.316

High

949264

JAGN1
Protein jagunal homolog 1

2

0

High-throughput

0.316

High

949269

FNDC9
Fibronectin type III domain-containing protein 9

2

0

High-throughput

0.316

High

949270

TM254
Transmembrane protein 254

2

0

High-throughput

0.316

High

949271

TM45B
Transmembrane protein 45B

2

0

High-throughput

0.316

High

949283

VAT1
Synaptic vesicle membrane protein VAT-1 homolog

2

0

High-throughput

0.316

High

949284

CYBC1
Cytochrome b-245 chaperone 1

2

0

High-throughput

0.316

High

949286

TM243
Transmembrane protein 243

2

0

High-throughput

0.316

High

949287

T106C
Transmembrane protein 106C

2

0

High-throughput

0.316

High

949292

SMIM3
Small integral membrane protein 3

2

0

High-throughput

0.316

High

949293

ELOV4
Very long chain fatty acid elongase 4

2

0

High-throughput

0.316

High

949294

MFF
Mitochondrial fission factor

2

0

High-throughput

0.316

High

949295

IF3M
Translation initiation factor IF-3, mitochondrial

2

0

High-throughput

0.316

High

949300

TM14B
Transmembrane protein 14B

2

0

High-throughput

0.316

High

949302

TM242
Transmembrane protein 242

2

0

High-throughput

0.316

High

949309

IR3IP
Immediate early response 3-interacting protein 1

2

0

High-throughput

0.316

High

275504

RTN2
Reticulon-2

1

0

High-throughput

0.279

Low

949234

U2AF1
Splicing factor U2AF 35 kDa subunit

1

0

High-throughput

0.279

Low

949255

STRP1
Striatin-interacting protein 1

1

0

High-throughput

0.279

Low

949265

F241A
Uncharacterized protein FAM241A

1

0

High-throughput

0.279

Low

949266

GALD1
Glutamine amidotransferase-like class 1 domain-containing protein 1

1

0

High-throughput

0.279

Low

193766

PER1
Period circadian protein homolog 1

1

0

High-throughput

0.268

Low

949237

RBBP4
Histone-binding protein RBBP4

1

0

High-throughput

0.268

Low

949254

TEX35
Testis-expressed protein 35

1

0

High-throughput

0.268

Low

949263

KLH36
Kelch-like protein 36

1

0

High-throughput

0.268

Low

949280

BBS4
BBSome complex member BBS4

1

0

High-throughput

0.268

Low

359960

NB5R3
NADH-cytochrome b5 reductase 3

1

0

High-throughput

0.251

Low

949253

TMM31
Transmembrane protein 31

1

0

High-throughput

0.251

Low

949310

FKBP7
Peptidyl-prolyl cis-trans isomerase FKBP7

1

0

High-throughput

0.251

Low

949250

DCAF6
DDB1- and CUL4-associated factor 6

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025