HitPredict

Interactor 1: CBX1 (P83916)
Chromobox protein homolog 1 (HP1Hsbeta) (Heterochromatin protein 1 homolog beta) (HP1 beta) (Heterochromatin protein p25) (M31) (Modifier 1 protein) (p25beta)
Gene: CBX1

Interactor 2: RBBP4 (Q09028)
Histone-binding protein RBBP4 (Chromatin assembly factor 1 subunit C) (CAF-1 subunit C) (Chromatin assembly factor I p48 subunit) (CAF-I 48 kDa subunit) (CAF-I p48) (Nucleosome-remodeling factor subunit RBAP48) (Retinoblastoma-binding protein 4) (RBBP-4) (Retinoblastoma-binding protein p48)
Gene: RBBP4

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.60	0.675

Property	Details
Experiments	27705803, 35271311, 24981860
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000781 - chromosome, telomeric region GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 185 Hs			1 425
+	Hs
		997703 CBX3_HUMAN (1-177): 2.11e-63: 195: 69.49		RBBP4_HUMAN (1-425): 4.3e-124: 367: 100.00
+	Mm
		1141931 CBX5_MOUSE (1-183): 7.63e-60: 186: 57.98		RBBP4_MOUSE (1-425): 4.3e-124: 367: 100.00
+	Hs
		800356 CBX5_HUMAN (1-183): 9.59e-60: 186: 57.45		RBBP4_HUMAN (1-425): 4.3e-124: 367: 100.00
+	Hs
		800395 CBX5_HUMAN (1-183): 9.59e-60: 186: 57.45		RBBP7_HUMAN (1-425): 3.63e-115: 345: 89.20
+	Mm
		222465 SUV91_MOUSE (13-121): 3.39e-30: 115: 21.10		RBBP4_MOUSE (1-425): 4.3e-124: 367: 100.00
+	Hs
		203672 SUV91_HUMAN (13-121): 4.22e-29: 112: 21.10		RBBP4_HUMAN (1-425): 4.3e-124: 367: 100.00
+	Hs
		997961 CDYL_HUMAN (7-120): 2.53e-25: 103: 25.86		RBBP4_HUMAN (1-425): 4.3e-124: 367: 100.00
+	Mm
		222466 SUV91_MOUSE (13-121): 3.39e-30: 115: 21.10		RBBP7_MOUSE (1-425): 1.21e-114: 343: 89.20
+	Hs
		203695 SUV91_HUMAN (13-121): 4.22e-29: 112: 21.10		RBBP7_HUMAN (1-425): 3.63e-115: 345: 89.20
+	Hs
		903191 CBX3_HUMAN (1-177): 2.11e-63: 195: 69.49		WDR5_HUMAN (267-425): 7.48e-35: 133: 25.61
+	Hs
		903125 CBX1_HUMAN (1-185): 2.21e-62: 193: 100.00		WDR5_HUMAN (267-425): 7.48e-35: 133: 25.61
+	Hs
		800458 CBX5_HUMAN (1-183): 9.59e-60: 186: 57.45		DAW1_HUMAN (9-106): 2.42e-20: 94.1: 8.74
+	Dm
		639969 PC_DROME (2-80): 1.9e-14: 72.2: 35.44		EBI_DROME (2-259): 3.6e-48: 176: 14.02
+	Hs
		903532 CBX8_HUMAN (12-88): 1.45e-24: 100: 35.07		WDR5_HUMAN (267-425): 7.48e-35: 133: 25.61
+	Hs
		203735 SUV91_HUMAN (13-121): 4.22e-29: 112: 21.10		DAW1_HUMAN (9-106): 2.42e-20: 94.1: 8.74
+	Hs
		1335779 CBX8_HUMAN (12-88): 1.45e-24: 100: 35.07		NLE1_HUMAN (8-106): 1.77e-21: 98.3: 10.58
+	At
		186933 LHP1_ARATH (17-109): 1.07e-14: 72.9: 34.04		MSI1_ARATH (2-210): 3.43e-31: 125: 13.22