Protein: KCC2B
Calcium/calmodulin-dependent protein kinase type II subunit beta (CaM kinase II subunit beta) (CaMK-II subunit beta) (EC 2.7.11.17)

Gene: KCC2B, CAMK2B
Organism: Homo sapiens
Interactions: 164
UniProt ID: Q13554

Gene Ontology (top 5):
GO:0003779 - actin binding
GO:0004683 - calcium/calmodulin-dependent protein kinase activity
GO:0005516 - calmodulin binding
GO:0005524 - ATP binding
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1110236

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

9

18

Small-scale

0.974

High

1110322

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

8

18

Small-scale

0.971

High

1110235

KCC2G
Calcium/calmodulin-dependent protein kinase type II subunit gamma

4

17

High-throughput

0.902

High

1110234

KCC2B
Calcium/calmodulin-dependent protein kinase type II subunit beta

4

16

Small-scale

0.889

High

959438

RAP2B
Ras-related protein Rap-2b

3

2

High-throughput

0.871

High

1110283

KPBB
Phosphorylase b kinase regulatory subunit beta

2

2

High-throughput

0.815

High

1110293

RBM42
RNA-binding protein 42

2

3

High-throughput

0.811

High

1110246

CDC37
Hsp90 co-chaperone Cdc37

2

3

High-throughput

0.783

High

211313

RFOX2
RNA binding protein fox-1 homolog 2

1

2

High-throughput

0.740

High

1110282

RBPMS
RNA-binding protein with multiple splicing

1

2

High-throughput

0.740

High

1110296

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

9

High-throughput

0.698

High

486692

FGR
Tyrosine-protein kinase Fgr

1

11

High-throughput

0.691

High

1110244

SLMAP
Sarcolemmal membrane-associated protein

1

4

High-throughput

0.691

High

1110263

PKN3
Serine/threonine-protein kinase N3

1

10

High-throughput

0.691

High

1110324

M3K2
Mitogen-activated protein kinase kinase kinase 2

1

4

High-throughput

0.691

High

1110272

TTC5
Tetratricopeptide repeat protein 5

3

3

High-throughput

0.675

High

1110312

MO4L1
Mortality factor 4-like protein 1

3

1

High-throughput

0.675

High

1110306

KTU
Protein kintoun

3

1

High-throughput

0.667

High

1110314

NUFP1
FMR1-interacting protein NUFIP1

3

1

High-throughput

0.667

High

1110276

ZN397
Zinc finger protein 397

1

0

High-throughput

0.656

High

228585

STRN
Striatin

2

8

High-throughput

0.628

High

529755

TAU
Microtubule-associated protein tau

2

17

High-throughput

0.628

High

1110325

ZBT32
Zinc finger and BTB domain-containing protein 32

1

4

High-throughput

0.621

High

74481

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

7

High-throughput

0.618

High

1110275

ZSCA1
Zinc finger and SCAN domain-containing protein 1

1

1

High-throughput

0.618

High

1110285

ZN764
Zinc finger protein 764

1

1

High-throughput

0.618

High

461450

HS90A
Heat shock protein HSP 90-alpha

1

11

High-throughput

0.618

High

468346

HS90B
Heat shock protein HSP 90-beta

1

11

High-throughput

0.618

High

958428

ACTZ
Alpha-centractin

1

8

High-throughput

0.618

High

1106830

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.618

High

1107685

SQSTM
Sequestosome-1

1

5

Small-scale

0.618

High

1110268

CK2N1
Calcium/calmodulin-dependent protein kinase II inhibitor 1

1

6

High-throughput

0.618

High

1110298

PKHA4
Pleckstrin homology domain-containing family A member 4

1

13

High-throughput

0.618

High

1110323

NINL
Ninein-like protein

1

6

High-throughput

0.618

High

1110328

RBM8A
RNA-binding protein 8A

1

3

High-throughput

0.618

High

1110326

RM11
Large ribosomal subunit protein uL11m

3

3

High-throughput

0.616

High

123381

BACH
Cytosolic acyl coenzyme A thioester hydrolase

2

0

High-throughput

0.612

High

124332

HAX1
HCLS1-associated protein X-1

3

1

High-throughput

0.609

High

909432

NDUA8
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8

3

2

High-throughput

0.609

High

164569

TNPO2
Transportin-2

2

3

High-throughput

0.606

High

227217

KRT86
Keratin, type II cuticular Hb6

2

1

High-throughput

0.606

High

1004532

RNF4
E3 ubiquitin-protein ligase RNF4

2

2

High-throughput

0.606

High

1059631

KRA11
Keratin-associated protein 1-1

2

3

High-throughput

0.606

High

1110245

MO4L2
Mortality factor 4-like protein 2

2

1

High-throughput

0.606

High

1110251

KRA62
Keratin-associated protein 6-2

2

1

High-throughput

0.606

High

1110261

DUS1L
tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like

2

2

High-throughput

0.606

High

1110267

KR193
Keratin-associated protein 19-3

2

2

High-throughput

0.606

High

1110291

PNKP
Bifunctional polynucleotide phosphatase/kinase

2

1

High-throughput

0.606

High

1110327

TNPO3
Transportin-3

2

5

High-throughput

0.606

High

712201

TKT
Transketolase

2

0

High-throughput

0.602

High

1110304

CCM2L
Cerebral cavernous malformations 2 protein-like

3

1

High-throughput

0.597

High

1110295

RPC3
DNA-directed RNA polymerase III subunit RPC3

2

0

High-throughput

0.580

High

1110329

NCOR2
Nuclear receptor corepressor 2

1

2

Small-scale

0.578

High

516335

CALM1
Calmodulin-1

1

20

High-throughput

0.575

High

516409

CALM2
Calmodulin-2

1

20

High-throughput

0.575

High

516511

CALM3
Calmodulin-3

1

20

High-throughput

0.575

High

581028

RAC2
Ras-related C3 botulinum toxin substrate 2

1

16

High-throughput

0.575

High

1110258

CF141
Uncharacterized protein C6orf141

2

1

High-throughput

0.574

High

1110273

ZN843
Zinc finger protein 843

2

1

High-throughput

0.574

High

1110253

KR195
Keratin-associated protein 19-5

1

1

High-throughput

0.573

High

1110254

KR197
Keratin-associated protein 19-7

1

1

High-throughput

0.573

High

1110316

ZMYM5
Zinc finger MYM-type protein 5

2

1

High-throughput

0.553

High

985646

RL11
Large ribosomal subunit protein uL5

1

0

High-throughput

0.549

High

1110284

POP5
Ribonuclease P/MRP protein subunit POP5

1

0

High-throughput

0.549

High

1110294

MED18
Mediator of RNA polymerase II transcription subunit 18

1

0

High-throughput

0.549

High

1110315

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

0

High-throughput

0.549

High

899882

FXR1
RNA-binding protein FXR1

1

18

High-throughput

0.541

High

900311

FXR2
RNA-binding protein FXR2

1

18

High-throughput

0.541

High

927281

ATX1
Ataxin-1

1

1

High-throughput

0.541

High

1056708

FMR1
Fragile X messenger ribonucleoprotein 1

1

18

High-throughput

0.541

High

1110299

SMYD3
Histone-lysine N-methyltransferase SMYD3

1

2

High-throughput

0.541

High

185669

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

5

High-throughput

0.536

High

354854

DNAL4
Dynein axonemal light chain 4

1

3

High-throughput

0.536

High

404036

GCR
Glucocorticoid receptor

1

10

High-throughput

0.536

High

698213

PDE4A
3',5'-cyclic-AMP phosphodiesterase 4A

1

6

High-throughput

0.536

High

702102

ITPI2
Protein ITPRID2

1

3

High-throughput

0.536

High

755908

MCM5
DNA replication licensing factor MCM5

1

4

High-throughput

0.536

High

906882

GPM6A
Neuronal membrane glycoprotein M6-a

1

1

High-throughput

0.536

High

1092874

STRN3
Striatin-3

1

9

High-throughput

0.536

High

1110241

ITPR2
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR2

1

11

High-throughput

0.536

High

1110242

ITPR3
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3

1

11

High-throughput

0.536

High

1110265

SHSA6
Protein shisa-6

1

2

High-throughput

0.536

High

1110277

NUP43
Nucleoporin Nup43

1

2

High-throughput

0.536

High

1110286

P121A
Nuclear envelope pore membrane protein POM 121

1

7

High-throughput

0.536

High

1110290

TCPQM
T-complex protein 1 subunit theta-like 2

1

3

High-throughput

0.536

High

1110297

E41LB
Band 4.1-like protein 4B

1

9

High-throughput

0.536

High

1110300

ELP3
Elongator complex protein 3

1

2

High-throughput

0.536

High

1110301

STRN4
Striatin-4

1

7

High-throughput

0.536

High

1110310

MAP10
Microtubule-associated protein 10

1

3

High-throughput

0.536

High

1110313

AAKG2
5'-AMP-activated protein kinase subunit gamma-2

1

3

High-throughput

0.536

High

1110317

HSPB8
Heat shock protein beta-8

1

2

High-throughput

0.536

High

1110318

TPC2L
Trafficking protein particle complex subunit 2-like protein

1

2

High-throughput

0.536

High

105881

APRIO
Alternative prion protein

2

6

High-throughput

0.533

High

687798

SYVC
Valine--tRNA ligase

1

2

High-throughput

0.515

High

950928

KR10B
Keratin-associated protein 10-11

1

3

High-throughput

0.515

High

1110252

KRA63
Keratin-associated protein 6-3

1

2

High-throughput

0.515

High

255006

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

12

High-throughput

0.514

High

351276

TTLL1
Polyglutamylase complex subunit TTLL1

1

0

High-throughput

0.513

High

868158

SYQ
Glutamine--tRNA ligase

1

0

High-throughput

0.513

High

1110257

EFMT2
EEF1A lysine methyltransferase 2

1

0

High-throughput

0.513

High

1110264

TRAT1
T-cell receptor-associated transmembrane adapter 1

1

0

High-throughput

0.513

High

1110280

TANK
TRAF family member-associated NF-kappa-B activator

1

0

High-throughput

0.513

High

1110287

VCIP1
Deubiquitinating protein VCPIP1

1

0

High-throughput

0.513

High

1110292

NAA11
N-alpha-acetyltransferase 11

1

0

High-throughput

0.513

High

1110309

RDH8
Retinol dehydrogenase 8

1

0

High-throughput

0.513

High

1110320

PALD
Paladin

1

0

High-throughput

0.513

High

1110321

PADI4
Protein-arginine deiminase type-4

1

0

High-throughput

0.513

High

729809

1433B
14-3-3 protein beta/alpha

1

20

Small-scale

0.501

High

504689

F163B
Protein FAM163B

1

2

High-throughput

0.489

High

848615

MAGA9
Melanoma-associated antigen 9

1

6

High-throughput

0.489

High

1110319

PNMA2
Paraneoplastic antigen Ma2

1

6

High-throughput

0.489

High

224704

ACTN4
Alpha-actinin-4

1

6

Small-scale

0.481

High

533341

THB
Thyroid hormone receptor beta

1

5

High-throughput

0.481

High

873156

RXRG
Retinoic acid receptor RXR-gamma

1

7

High-throughput

0.481

High

893852

MEOX2
Homeobox protein MOX-2

1

1

High-throughput

0.481

High

950758

KR109
Keratin-associated protein 10-9

1

3

High-throughput

0.481

High

1110243

MVP
Major vault protein

1

1

High-throughput

0.481

High

227869

MYO1B
Unconventional myosin-Ib

1

5

High-throughput

0.479

High

258596

SH21A
SH2 domain-containing protein 1A

1

15

High-throughput

0.479

High

301038

RL1D1
Ribosomal L1 domain-containing protein 1

1

2

High-throughput

0.479

High

551028

PCNA
Proliferating cell nuclear antigen

1

1

High-throughput

0.479

High

637894

NF1
Neurofibromin

1

11

High-throughput

0.479

High

977483

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

1

9

High-throughput

0.479

High

994210

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

9

High-throughput

0.479

High

1110238

CUL4A
Cullin-4A

1

9

High-throughput

0.479

High

1110247

DGUOK
Deoxyguanosine kinase, mitochondrial

1

1

High-throughput

0.479

High

1110249

CL16A
Protein CLEC16A

1

2

High-throughput

0.479

High

1110256

DCAF6
DDB1- and CUL4-associated factor 6

1

3

High-throughput

0.479

High

1110266

CBAR2
CBY1-interacting BAR domain-containing protein 2

1

2

High-throughput

0.479

High

1110279

TF2H4
General transcription factor IIH subunit 4

1

2

High-throughput

0.479

High

1110281

CSN5
COP9 signalosome complex subunit 5

1

1

High-throughput

0.479

High

1110288

CI072
Guanine nucleotide exchange factor C9orf72

1

2

High-throughput

0.479

High

1110307

ARMC1
Armadillo repeat-containing protein 1

1

1

High-throughput

0.479

High

340438

DUS4L
tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like

1

2

High-throughput

0.470

High

75769

B3KWQ7
cDNA FLJ43600 fis, clone SPLEN2002147, weakly similar to Halocynthia roretzi HrPET-3

1

1

High-throughput

0.470

High

1110260

Q6FHY5
MEOX2 protein

1

1

High-throughput

0.470

High

1110330

X5DP17
Major vault protein isoform H

1

1

High-throughput

0.457

High

404780

PRIO
Major prion protein

1

4

High-throughput

0.445

High

1110237

CUL3
Cullin-3

1

9

High-throughput

0.445

High

1110239

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

7

High-throughput

0.445

High

1110248

TPD53
Tumor protein D53

1

2

High-throughput

0.445

High

1110269

RIMS1
Regulating synaptic membrane exocytosis protein 1

1

8

High-throughput

0.445

High

1110289

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

11

High-throughput

0.445

High

71322

F1712
Protein FAM171A2

1

1

High-throughput

0.439

High

1108780

ASAH1
Acid ceramidase

1

1

High-throughput

0.437

High

1110262

FBX42
F-box only protein 42

1

2

High-throughput

0.437

High

1110305

PLCE
1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon

1

2

High-throughput

0.437

High

1110311

GABR1
Gamma-aminobutyric acid type B receptor subunit 1

1

7

Small-scale

0.437

High

1110308

TRM1
tRNA

1

0

High-throughput

0.426

High

2894

A0A0C4DGF1
Zinc finger and BTB domain containing 32

1

3

High-throughput

0.417

High

1110274

GG6L2
Golgin subfamily A member 6-like protein 2

1

6

High-throughput

0.407

High

1110250

AP5B1
AP-5 complex subunit beta-1

2

0

High-throughput

0.335

High

1110278

LIPH
Lipase member H

2

0

High-throughput

0.318

High

582329

ARSA
Arylsulfatase A

2

0

High-throughput

0.316

High

1110259

SPRY7
SPRY domain-containing protein 7

1

0

High-throughput

0.299

High

1110302

SEM4G
Semaphorin-4G

1

0

High-throughput

0.299

High

50022

F170A
Protein FAM170A

1

0

High-throughput

0.279

Low

229273

ANGL7
Angiopoietin-related protein 7

1

0

High-throughput

0.279

Low

1110240

PIGH
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H

1

0

High-throughput

0.279

Low

1110270

WDR5B
WD repeat-containing protein 5B

1

0

High-throughput

0.279

Low

1110303

CT096
Uncharacterized protein C20orf96

1

0

High-throughput

0.279

Low

1110271

Q8N0U1
Alternative protein FAM171A2

1

0

High-throughput

0.268

Low

1110255

MGT5B
Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B

1

0

High-throughput

0.251

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025