Interactor 1: SMAD3 (P84022)
Mothers against decapentaplegic homolog 3 (MAD homolog 3) (Mad3) (Mothers against DPP homolog 3) (hMAD-3) (JV15-2) (SMAD family member 3) (SMAD 3) (Smad3) (hSMAD3)
Gene: SMAD3
Interactor 2: SMAD4 (Q13485)
Mothers against decapentaplegic homolog 4 (MAD homolog 4) (Mothers against DPP homolog 4) (Deletion target in pancreatic carcinoma 4) (SMAD family member 4) (SMAD 4) (Smad4) (hSMAD4)
Gene: SMAD4
Species: Homo sapiens
Source: mint
Category: Small-scale
Confidence: High
Method score | Annotation score | Interaction score |
---|---|---|
0.99 | 1.00 | 0.997 |
The method score is based on:
Property | Details |
---|---|
Experiments | 11927552, 15588252, 25609649, 28115363, 12794086, 29997244, 29892012, 27703004, 31591477, 10531362, 22045334, 19135894, 10878024, 10995777, 21532621, 19768112, 15761153, 17591701, 10092624, 9111321 and 42 others
more... |
Identification Methods | affinity chromatography technology, fluorescent resonance energy transfer, two hybrid, pull down, protein complementation assay, x-ray crystallography, anti tag coimmunoprecipitation, electrophoretic mobility supershift assay, tandem affinity purification, two hybrid array and 5 others
more... |
Interaction Type | physical association, direct interaction, association |
The annotation score is based on:
Property | Details |
---|---|
Interacting Pfam domains | MH1~MH1, MH2~MH2 |
Common GO terms | GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000785 - chromatin GO:0000976 - transcription cis-regulatory region binding GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific and 43 others more... |
Homologous interactions | 19 |
Homologous interactions
Color coding for hit scores
Service provided by Combinatics, Japan
Last updated: 15 Jul 2024