Interactor 1: SMAD3 (P84022)
Mothers against decapentaplegic homolog 3 (MAD homolog 3) (Mad3) (Mothers against DPP homolog 3) (hMAD-3) (JV15-2) (SMAD family member 3) (SMAD 3) (Smad3) (hSMAD3)
Gene: SMAD3

Interactor 2: SMAD4 (Q13485)
Mothers against decapentaplegic homolog 4 (MAD homolog 4) (Mothers against DPP homolog 4) (Deletion target in pancreatic carcinoma 4) (SMAD family member 4) (SMAD 4) (Smad4) (hSMAD4)
Gene: SMAD4

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.99 1.00 0.997

The method score is based on:

Property Details
Experiments 11927552, 15588252, 25609649, 28115363, 12794086, 29997244, 29892012, 27703004, 31591477, 10531362, 22045334, 19135894, 10878024, 10995777, 21532621, 19768112, 15761153, 17591701, 10092624, 9111321 and 42 others

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Identification Methods affinity chromatography technology, fluorescent resonance energy transfer, two hybrid, pull down, protein complementation assay, x-ray crystallography, anti tag coimmunoprecipitation, electrophoretic mobility supershift assay, tandem affinity purification, two hybrid array and 5 others

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Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains MH1~MH1, MH2~MH2
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000976 - transcription cis-regulatory region binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
and 43 others

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Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 425
Hs

1 552
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Last updated: 15 Jul 2024