HitPredict

Interactor 1: SMAD3 (P84022)
Mothers against decapentaplegic homolog 3 (MAD homolog 3) (Mad3) (Mothers against DPP homolog 3) (hMAD-3) (JV15-2) (SMAD family member 3) (SMAD 3) (Smad3) (hSMAD3)
Gene: SMAD3

Interactor 2: UCHL5 (Q9Y5K5)
Ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCH-L5) (EC 3.4.19.12) (Ubiquitin C-terminal hydrolase UCH37) (Ubiquitin thioesterase L5)
Gene: UCHL5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	27604640, 16027725
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0045893 - positive regulation of DNA-templated transcription
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 425 Hs			1 329
+	Hs
		1078708 SMAD2_HUMAN (1-425): 0: 589: 83.73		UCHL5_HUMAN (1-329): 1.1e-175: 491: 100.00
+	Hs
		456545 SMAD3_HUMAN (1-425): 0: 636: 100.00		UCHL1_HUMAN (10-226): 1.03e-74: 231: 22.22
+	Hs
		456574 SMAD2_HUMAN (1-425): 0: 589: 83.73		UCHL1_HUMAN (10-226): 1.03e-74: 231: 22.22
+	Hs
		548101 SMAD1_HUMAN (1-425): 0: 559: 60.09		UCHL3_HUMAN (4-226): 7.17e-85: 257: 26.18
+	Mm
		936625 SMAD1_MOUSE (1-425): 0: 560: 59.87		UCHL3_MOUSE (4-226): 2.22e-84: 256: 26.61
+	Hs
		167415 SMAD7_HUMAN (28-403): 2.71e-101: 309: 27.06		UCHL5_HUMAN (1-329): 1.1e-175: 491: 100.00
+	Hs
		456561 SMAD4_HUMAN (23-414): 1.55e-117: 355: 33.21		UCHL1_HUMAN (10-226): 1.03e-74: 231: 22.22