Protein: THAP1
THAP domain-containing protein 1

Gene: THAP1
Organism: Homo sapiens
Interactions: 124
UniProt ID: Q9NVV9

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

789234

NUP62
Nuclear pore glycoprotein p62

6

2

High-throughput

0.744

High

1450888

THAP1
THAP domain-containing protein 1

6

7

High-throughput

0.741

High

1286224

RALYL
RNA-binding Raly-like protein

5

4

High-throughput

0.729

High

1402785

STRBP
Spermatid perinuclear RNA-binding protein

5

2

High-throughput

0.722

High

1392933

NTAQ1
Protein N-terminal glutamine amidohydrolase

5

2

High-throughput

0.720

High

998061

CSK21
Casein kinase II subunit alpha

4

1

High-throughput

0.705

High

1089273

TRI26
Tripartite motif-containing protein 26

4

2

High-throughput

0.700

High

1348976

ZCH10
Zinc finger CCHC domain-containing protein 10

4

0

High-throughput

0.677

High

136731

TRAF5
TNF receptor-associated factor 5

3

9

High-throughput

0.675

High

1034621

AK17A
A-kinase anchor protein 17A

3

1

High-throughput

0.675

High

1127192

RBM39
RNA-binding protein 39

3

2

High-throughput

0.675

High

1150183

TCEA2
Transcription elongation factor A protein 2

3

1

High-throughput

0.675

High

1450895

BAG5
BAG family molecular chaperone regulator 5

4

0

High-throughput

0.668

High

210356

PHF1
PHD finger protein 1

3

3

High-throughput

0.667

High

1023188

RBM10
RNA-binding protein 10

3

1

High-throughput

0.667

High

1437001

ZN408
Zinc finger protein 408

3

2

High-throughput

0.667

High

1226441

Z385C
Zinc finger protein 385C

3

1

High-throughput

0.654

High

123449

BACH
Cytosolic acyl coenzyme A thioester hydrolase

3

0

High-throughput

0.646

High

1068930

RIPP1
Protein ripply1

3

0

High-throughput

0.646

High

1119011

BYST
Bystin

3

0

High-throughput

0.646

High

1450889

GPT2L
G patch domain-containing protein 2-like

3

0

High-throughput

0.646

High

685749

U2AF2
Splicing factor U2AF 65 kDa subunit

2

2

High-throughput

0.646

High

905496

HCFC1
Host cell factor 1

2

9

Small-scale

0.637

High

156356

G3PT
Glyceraldehyde-3-phosphate dehydrogenase, testis-specific

3

0

High-throughput

0.634

High

1329646

EFNMT
eEF1A lysine and N-terminal methyltransferase

3

0

High-throughput

0.633

High

1358674

HNRLL
Heterogeneous nuclear ribonucleoprotein L-like

2

1

High-throughput

0.633

High

1411198

CHOLN
Protein cholesin

3

1

High-throughput

0.616

High

159879

DVL2
Segment polarity protein dishevelled homolog DVL-2

2

2

High-throughput

0.608

High

193068

FGF10
Fibroblast growth factor 10

2

3

High-throughput

0.606

High

517714

ZBT48
Zinc finger and BTB domain-containing protein 48

2

2

High-throughput

0.606

High

937509

CDN2D
Cyclin-dependent kinase 4 inhibitor D

2

1

High-throughput

0.606

High

961224

FGF12
Fibroblast growth factor 12

2

3

High-throughput

0.606

High

1005157

RNF4
E3 ubiquitin-protein ligase RNF4

2

1

High-throughput

0.606

High

1213593

PHF19
PHD finger protein 19

2

3

High-throughput

0.606

High

1225090

KANK2
KN motif and ankyrin repeat domain-containing protein 2

2

3

High-throughput

0.606

High

1327467

ZGPAT
Zinc finger CCCH-type with G patch domain-containing protein

2

3

High-throughput

0.606

High

1331110

TEANC
Transcription elongation factor A N-terminal and central domain-containing protein

2

1

High-throughput

0.606

High

1347396

LMO3
LIM domain only protein 3

2

2

High-throughput

0.606

High

1348539

LNX1
E3 ubiquitin-protein ligase LNX

2

1

High-throughput

0.606

High

1353601

ZN526
Zinc finger protein 526

2

4

High-throughput

0.606

High

1370584

FGF11
Fibroblast growth factor 11

2

3

High-throughput

0.606

High

1380977

LMBL2
Lethal(3)malignant brain tumor-like protein 2

2

1

High-throughput

0.606

High

1450897

ARIP4
Helicase ARIP4

2

3

High-throughput

0.606

High

447872

TPM3
Tropomyosin alpha-3 chain

3

2

High-throughput

0.597

High

156511

ACPM
Acyl carrier protein, mitochondrial

2

0

High-throughput

0.580

High

353751

DRC4
Dynein regulatory complex subunit 4

2

0

High-throughput

0.580

High

770312

RL22
Large ribosomal subunit protein eL22

2

0

High-throughput

0.580

High

935639

MFAP1
Microfibrillar-associated protein 1

2

0

High-throughput

0.580

High

1007990

PO6F2
POU domain, class 6, transcription factor 2

2

0

High-throughput

0.580

High

1150897

CIP4
Cdc42-interacting protein 4

2

0

High-throughput

0.580

High

1332158

SR1IP
Protein SREK1IP1

2

0

High-throughput

0.580

High

1403542

PNKP
Bifunctional polynucleotide phosphatase/kinase

2

0

High-throughput

0.580

High

1420619

IN80B
INO80 complex subunit B

2

0

High-throughput

0.580

High

1450891

MS18A
Protein Mis18-alpha

2

0

High-throughput

0.580

High

160209

CHD2
Chromodomain-helicase-DNA-binding protein 2

1

2

High-throughput

0.573

High

1136867

MO4L2
Mortality factor 4-like protein 2

1

1

High-throughput

0.573

High

1215373

DCAF8
DDB1- and CUL4-associated factor 8

1

3

High-throughput

0.573

High

1450892

MO4L1
Mortality factor 4-like protein 1

1

2

High-throughput

0.573

High

1450898

KLF12
Krueppel-like factor 12

1

6

High-throughput

0.573

High

1042088

LMNB2
Lamin-B2

2

2

High-throughput

0.553

High

1158571

CDC37
Hsp90 co-chaperone Cdc37

2

1

High-throughput

0.553

High

335513

SLU7
Pre-mRNA-splicing factor SLU7

1

0

High-throughput

0.549

High

983069

RS25
Small ribosomal subunit protein eS25

1

0

High-throughput

0.549

High

983718

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

1

0

High-throughput

0.549

High

1095468

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

1

0

High-throughput

0.549

High

1104996

PPIG
Peptidyl-prolyl cis-trans isomerase G

1

0

High-throughput

0.549

High

1226811

AR6P4
ADP-ribosylation factor-like protein 6-interacting protein 4

1

0

High-throughput

0.549

High

1408546

AKAP9
A-kinase anchor protein 9

1

0

High-throughput

0.549

High

1450893

S30BP
SAP30-binding protein

1

0

High-throughput

0.549

High

624528

WT1
Wilms tumor protein

1

5

High-throughput

0.541

High

1017756

PR20A
Proline-rich protein 20A

2

2

High-throughput

0.533

High

950420

KR107
Keratin-associated protein 10-7

1

11

High-throughput

0.523

High

1133181

LASP1
LIM and SH3 domain protein 1

1

2

High-throughput

0.523

High

900534

FXR2
RNA-binding protein FXR2

1

0

High-throughput

0.518

High

1327663

NKAP
NF-kappa-B-activating protein

1

0

High-throughput

0.518

High

1400080

QKI
KH domain-containing RNA-binding protein QKI

1

0

High-throughput

0.518

High

1404449

CDC5L
Cell division cycle 5-like protein

1

0

High-throughput

0.513

High

1394528

PAWR
PRKC apoptosis WT1 regulator protein

1

0

Small-scale

0.504

High

423303

A4
Amyloid-beta precursor protein

1

5

High-throughput

0.501

High

1358309

STAG1
Cohesin subunit SA-1

1

0

High-throughput

0.493

High

713136

NOS3
Nitric oxide synthase 3

1

0

High-throughput

0.493

High

857362

CDN1B
Cyclin-dependent kinase inhibitor 1B

1

0

High-throughput

0.493

High

993774

UBC9
SUMO-conjugating enzyme UBC9

1

2

High-throughput

0.481

High

1252571

AEBP2
Zinc finger protein AEBP2

1

5

High-throughput

0.481

High

1450894

RALY
RNA-binding protein Raly

1

3

High-throughput

0.481

High

186066

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

4

Small-scale

0.479

High

331361

KI20A
Kinesin-like protein KIF20A

1

3

High-throughput

0.479

High

941581

CTBP2
C-terminal-binding protein 2

1

2

High-throughput

0.479

High

980426

H4
Histone H4

1

2

High-throughput

0.479

High

570613

GFAP
Glial fibrillary acidic protein

1

1

High-throughput

0.470

High

1017622

PR20C
Proline-rich protein 20C

1

2

High-throughput

0.470

High

1017680

PR20D
Proline-rich protein 20D

1

2

High-throughput

0.470

High

1187448

Q3SXR9
VCX2 protein

1

1

High-throughput

0.470

High

1199174

Q53GL6
RNA binding protein

1

3

High-throughput

0.470

High

1218099

Q5VU62
TPM3 protein

1

2

High-throughput

0.470

High

1270730

Q7KZS0
SUMO-conjugating enzyme UBC9

1

2

High-throughput

0.470

High

1016381

SERF2
Small EDRK-rich factor 2

1

0

High-throughput

0.460

High

1450890

HYPK
Huntingtin-interacting protein K

1

0

High-throughput

0.460

High

564446

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.445

High

1432470

VCX2
Variable charge X-linked protein 2

1

1

High-throughput

0.439

High

1450066

ABCF3
ATP-binding cassette sub-family F member 3

1

1

High-throughput

0.439

High

3592

A0A0S2Z645
ATP-binding cassette sub-family F member 3 isoform 2

1

1

High-throughput

0.417

High

1413994

MMTA2
Multiple myeloma tumor-associated protein 2

4

0

High-throughput

0.368

High

463244

YES
Tyrosine-protein kinase Yes

3

0

High-throughput

0.352

High

1256744

NKAP1
Uncharacterized protein NKAPD1

3

0

High-throughput

0.352

High

1331793

F133A
Protein FAM133A

3

0

High-throughput

0.352

High

989135

AP2B1
AP-2 complex subunit beta

2

0

High-throughput

0.337

High

1450896

RM11
Large ribosomal subunit protein uL11m

2

0

High-throughput

0.327

High

298235

DCTN3
Dynactin subunit 3

2

0

High-throughput

0.318

High

1208338

SPXN2
Sperm protein associated with the nucleus on the X chromosome N2

2

0

High-throughput

0.316

High

1317052

FAM9A
Protein FAM9A

2

0

High-throughput

0.316

High

1330688

BEND7
BEN domain-containing protein 7

2

0

High-throughput

0.316

High

1346706

CA216
UPF0500 protein C1orf216

2

0

High-throughput

0.316

High

1389294

RM53
Large ribosomal subunit protein mL53

2

0

High-throughput

0.316

High

1397213

SMIP2
Protein SPMIP2

2

0

High-throughput

0.316

High

1256946

TTL10
Inactive polyglycylase TTLL10

1

0

High-throughput

0.299

High

1275886

PCLI1
PTB-containing, cubilin and LRP1-interacting protein

1

0

High-throughput

0.299

High

1289933

F124A
Protein FAM124A

1

0

High-throughput

0.299

High

47424

A0A6Q8PF08
Peripheral myelin protein 22

1

0

High-throughput

0.268

Low

622286

NDUV2
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial

1

0

High-throughput

0.268

Low

1232029

GL1AD
DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5

1

0

High-throughput

0.251

Low

1407200

THIOM
Thioredoxin, mitochondrial

1

0

High-throughput

0.251

Low

506036

GRL1A
DNA-directed RNA polymerase II subunit GRINL1A

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025