HitPredict

Interactor 1: ARF5 (P84085)
ADP-ribosylation factor 5
Gene: ARF5

Interactor 2: COPG2 (Q9UBF2)
Coatomer subunit gamma-2 (Gamma-2-coat protein) (Gamma-2-COP)
Gene: COPG2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.737

Property	Details
Experiments	35844135, 35271311
Identification Methods	proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Adaptin_N~Arf
Common GO terms	GO:0006886 - intracellular protein transport GO:0006890 - retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 180 Hs			1 871
+	Hs
		913157 ARF6_HUMAN (5-179): 5.26e-74: 221: 64.00		COPG2_HUMAN (1-871): 0: 869: 100.00
+	Hs
		574769 ARF4_HUMAN (1-180): 3.62e-70: 212: 90.00		COPG2_HUMAN (1-871): 0: 869: 100.00
+	Hs
		897411 ARF3_HUMAN (1-180): 4.68e-67: 204: 78.89		COPG2_HUMAN (1-871): 0: 869: 100.00
+	Hs
		913217 ARF6_HUMAN (5-179): 5.26e-74: 221: 64.00		COPG1_HUMAN (1-871): 0: 844: 80.44
+	Hs
		574783 ARF4_HUMAN (1-180): 3.62e-70: 212: 90.00		COPG1_HUMAN (1-871): 0: 844: 80.44
+	Hs
		950752 ARF5_HUMAN (1-180): 1.69e-69: 210: 100.00		COPG1_HUMAN (1-871): 0: 844: 80.44
+	Hs
		950585 ARF1_HUMAN (1-180): 3.45e-67: 204: 80.56		COPG1_HUMAN (1-871): 0: 844: 80.44
+	Dm
		778370 ARF4_DROME (1-180): 1.02e-77: 231: 83.89		COPG_DROME (11-871): 0: 731: 58.80
+	Dm
		897447 ARF1_DROME (1-179): 1.52e-66: 202: 79.89		COPG_DROME (11-871): 0: 731: 58.80
+	Zm
		30041 B4FB55_MAIZE (8-180): 6.02e-66: 202: 17.42		A0A1D6K3D9_MAIZE (63-870): 0: 637: 14.93
+	Hs
		321520 ARF6_HUMAN (5-179): 5.26e-74: 221: 64.00		AP2A1_HUMAN (24-871): 0: 567: 14.88
+	Dm
		778364 ARF4_DROME (1-180): 1.02e-77: 231: 83.89		Q24253_DROME (14-869): 6.53e-177: 536: 13.08
+	Hs
		912875 ARF6_HUMAN (5-179): 5.26e-74: 221: 64.00		AP1B1_HUMAN (14-638): 2.54e-177: 538: 14.84
+	Hs
		912839 ARF6_HUMAN (5-179): 5.26e-74: 221: 64.00		AP2B1_HUMAN (14-600): 2.1e-176: 535: 14.45
+	Sc
		503061 ARF1_YEAST (1-179): 4.21e-78: 232: 69.83		COPG_YEAST (7-870): 1.02e-167: 513: 32.34
+	Hs
		950481 ARF1_HUMAN (1-180): 3.45e-67: 204: 80.56		AP1B1_HUMAN (14-638): 2.54e-177: 538: 14.84
+	Dm
		897433 ARF1_DROME (1-179): 1.52e-66: 202: 79.89		Q24253_DROME (14-869): 6.53e-177: 536: 13.08
+	Hs
		212615 ARF6_HUMAN (5-179): 5.26e-74: 221: 64.00		AP1G1_HUMAN (20-738): 1.94e-170: 516: 15.07
+	Hs
		212618 ARF1_HUMAN (1-180): 3.45e-67: 204: 80.56		AP1G1_HUMAN (20-738): 1.94e-170: 516: 15.07