HitPredict

Interactor 1: SRSF3 (P84103)
Serine/arginine-rich splicing factor 3 (Pre-mRNA-splicing factor SRP20) (Splicing factor, arginine/serine-rich 3)
Gene: SRSF3

Interactor 2: EWS (Q01844)
RNA-binding protein EWS (EWS oncogene) (Ewing sarcoma breakpoint region 1 protein)
Gene: EWSR1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	24999758, 29884807
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0005654 - nucleoplasm GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 164 Hs			1 656
+	Hs
		1084353 SRSF7_HUMAN (9-106): 1.02e-30: 112: 67.35		RBP56_HUMAN (109-555): 5.78e-53: 193: 35.05
+	Mm
		952207 SRSF3_MOUSE (1-164): 6.39e-27: 100: 100.00		Q8BQ46_MOUSE (109-555): 4.7e-53: 193: 35.35
+	Hs
		992865 SRSF1_HUMAN (9-80): 1.1e-25: 100: 48.65		RBP56_HUMAN (109-555): 5.78e-53: 193: 35.05
+	Hs
		967211 SRSF7_HUMAN (9-106): 1.02e-30: 112: 67.35		EWS_HUMAN (1-656): 1.54e-47: 179: 100.00
+	Hs
		1031411 PABP4_HUMAN (5-91): 1.61e-21: 91.9: 26.09		RBP56_HUMAN (109-555): 5.78e-53: 193: 35.05
+	Hs
		516620 PABP1_HUMAN (1-91): 1.13e-20: 89.6: 25.77		RBP56_HUMAN (109-555): 5.78e-53: 193: 35.05
+	Hs
		703370 CSTF2_HUMAN (10-110): 1.87e-25: 103: 25.47		EWS_HUMAN (1-656): 1.54e-47: 179: 100.00
+	Hs
		967128 SRSF1_HUMAN (9-80): 1.1e-25: 100: 48.65		EWS_HUMAN (1-656): 1.54e-47: 179: 100.00
+	Hs
		967422 CSTFT_HUMAN (10-110): 1.69e-24: 100: 24.53		EWS_HUMAN (1-656): 1.54e-47: 179: 100.00
+	Hs
		726852 SRSF7_HUMAN (9-106): 1.02e-30: 112: 67.35		FUS_HUMAN (55-545): 1.15e-31: 131: 30.35
+	Hs
		703359 CSTF2_HUMAN (10-110): 1.87e-25: 103: 25.47		FUS_HUMAN (55-545): 1.15e-31: 131: 30.35
+	Hs
		726746 SRSF3_HUMAN (1-164): 6.39e-27: 100: 100.00		FUS_HUMAN (55-545): 1.15e-31: 131: 30.35
+	Hs
		726769 SRSF1_HUMAN (9-80): 1.1e-25: 100: 48.65		FUS_HUMAN (55-545): 1.15e-31: 131: 30.35
+	Hs
		726792 SRSF5_HUMAN (10-112): 2.09e-24: 97: 44.34		FUS_HUMAN (55-545): 1.15e-31: 131: 30.35
+	Hs
		266927 SRS10_HUMAN (1-164): 2.25e-24: 96.6: 32.54		FUS_HUMAN (55-545): 1.15e-31: 131: 30.35
+	Hs
		726675 NCBP2_HUMAN (7-117): 3.6e-25: 96.1: 24.14		FUS_HUMAN (55-545): 1.15e-31: 131: 30.35
+	Hs
		726795 PABP4_HUMAN (5-91): 1.61e-21: 91.9: 26.09		FUS_HUMAN (55-545): 1.15e-31: 131: 30.35
+	Hs
		516383 PABP1_HUMAN (1-91): 1.13e-20: 89.6: 25.77		FUS_HUMAN (55-545): 1.15e-31: 131: 30.35
+	Hs
		212116 NCBP2_HUMAN (7-117): 3.6e-25: 96.1: 24.14		HTSF1_HUMAN (310-448): 3.35e-28: 122: 20.55
+	Mm
		882705 SRS10_MOUSE (1-164): 2.25e-24: 96.6: 32.54		FUS_MOUSE (66-545): 4.19e-27: 117: 32.08