HitPredict

Interactor 1: H33 (P84243)
Histone H3.3
Gene: H3-3A

Interactor 2: CENPC (Q03188)
Centromere protein C (CENP-C) (Centromere autoantigen C) (Centromere protein C 1) (CENP-C 1) (Interphase centromere complex protein 7)
Gene: CENPC

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	36089195
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	CENP-C_mid~Histone
Common GO terms	GO:0000939 - inner kinetochore GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 136 Hs			1 943
+	Hs
		934682 H31_HUMAN (1-136): 3.08e-60: 183: 96.32		CENPC_HUMAN (1-943): 0: 559: 100.00
+	Hs
		828203 CENPA_HUMAN (9-133): 2.42e-45: 146: 50.76		CENPC_HUMAN (1-943): 0: 559: 100.00
+	Mm
		82711 B9EI85_MOUSE (1-136): 5.32e-59: 180: 97.06		CENPC_MOUSE (1-943): 1.36e-146: 459: 49.95
+	Mm
		828449 H32_MOUSE (1-136): 5.32e-59: 180: 97.06		CENPC_MOUSE (1-943): 1.36e-146: 459: 49.95
+	Mm
		192380 CENPA_MOUSE (16-133): 3.33e-45: 145: 46.46		CENPC_MOUSE (1-943): 1.36e-146: 459: 49.95
+	Hs
		934881 H31_HUMAN (1-136): 3.08e-60: 183: 96.32		NIPBL_HUMAN (32-885): 3.58e-111: 380: 14.35
+	Hs
		952407 H33_HUMAN (1-136): 1.12e-59: 182: 100.00		NIPBL_HUMAN (32-885): 3.58e-111: 380: 14.35
+	Hs
		828271 CENPA_HUMAN (9-133): 2.42e-45: 146: 50.76		NIPBL_HUMAN (32-885): 3.58e-111: 380: 14.35
+	Gg
		223340 CENPA_CHICK (45-133): 3.97e-26: 97.1: 61.54		O57392_CHICK (175-942): 4.52e-68: 246: 23.14
+	Sc
		716085 CENPA_YEAST (18-134): 3.39e-40: 135: 56.67		CENPC_YEAST (698-941): 4.33e-33: 137: 17.31
+	Hs
		935049 H31_HUMAN (1-136): 3.08e-60: 183: 96.32		TITIN_HUMAN (74-845): 1.85e-10: 67.6: 10.55
+	Hs
		1174610 H32_HUMAN (1-136): 5.32e-59: 180: 97.06		TITIN_HUMAN (74-845): 1.85e-10: 67.6: 10.55