HitPredict

Interactor 1: H33 (P84243)
Histone H3.3
Gene: H3-3A

Interactor 2: IWS1 (Q96ST2)
Protein IWS1 homolog (IWS1-like protein)
Gene: IWS1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	33961781, 36089195
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 136 Hs			1 819
+	Hs
		935147 H31_HUMAN (1-136): 3.08e-60: 183: 96.32		IWS1_HUMAN (1-819): 1.85e-132: 416: 100.00
+	Sc
		902085 H3_YEAST (1-136): 3.62e-54: 168: 90.44		IWS1_YEAST (408-804): 1.94e-38: 150: 22.87
+	Hs
		934668 H31_HUMAN (1-136): 3.08e-60: 183: 96.32		ANK2_HUMAN (22-447): 1.53e-27: 122: 11.87
+	Hs
		965127 H32_HUMAN (1-136): 5.32e-59: 180: 97.06		ANK2_HUMAN (22-447): 1.53e-27: 122: 11.87
+	Hs
		152625 H31_HUMAN (1-136): 3.08e-60: 183: 96.32		KMT2D_HUMAN (8-481): 2.23e-10: 66.8: 13.13
+	Hs
		935121 H31_HUMAN (1-136): 3.08e-60: 183: 96.32		CHAP1_HUMAN (4-585): 8.55e-10: 64.5: 12.54
+	Hs
		152661 H32_HUMAN (1-136): 5.32e-59: 180: 97.06		KMT2D_HUMAN (8-481): 2.23e-10: 66.8: 13.13
+	Hs
		952550 H33_HUMAN (1-136): 1.12e-59: 182: 100.00		CHAP1_HUMAN (4-585): 8.55e-10: 64.5: 12.54
+	Hs
		1086277 H31T_HUMAN (1-136): 2.58e-59: 181: 93.38		CHAP1_HUMAN (4-585): 8.55e-10: 64.5: 12.54
+	Hs
		935049 H31_HUMAN (1-136): 3.08e-60: 183: 96.32		TITIN_HUMAN (1-582): 6.22e-09: 62.2: 10.64
+	Hs
		1174610 H32_HUMAN (1-136): 5.32e-59: 180: 97.06		TITIN_HUMAN (1-582): 6.22e-09: 62.2: 10.64
+	Sc
		730797 CENPA_YEAST (18-134): 3.39e-40: 135: 56.67		SEC31_YEAST (4-490): 3.98e-10: 65.7: 11.70