Protein: MYL6B
Myosin light chain 6B (Myosin light chain 1 slow-twitch muscle A isoform) (MLC1sa) (Smooth muscle and nonmuscle myosin light chain alkali 6B)

Gene: MYL6B
Organism: Homo sapiens
Interactions: 119
UniProt ID: P14649

Gene Ontology (top 5):
GO:0003774 - cytoskeletal motor activity
GO:0005509 - calcium ion binding
GO:0005829 - cytosol
GO:0005859 - muscle myosin complex
GO:0006936 - muscle contraction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

573939

MYL6
Myosin light polypeptide 6

4

17

High-throughput

0.699

High

573933

IQGA1
Ras GTPase-activating-like protein IQGAP1

4

20

Small-scale

0.694

High

573928

MYH9
Myosin-9

3

18

High-throughput

0.667

High

573997

ANLN
Anillin

3

2

High-throughput

0.656

High

573943

RAC1
Ras-related C3 botulinum toxin substrate 1

3

12

High-throughput

0.650

High

169049

ML12B
Myosin regulatory light chain 12B

2

19

High-throughput

0.601

High

573980

MY18A
Unconventional myosin-XVIIIa

2

20

High-throughput

0.601

High

573972

IQGA3
Ras GTPase-activating-like protein IQGAP3

2

20

High-throughput

0.571

High

395423

ESR1
Estrogen receptor

1

3

High-throughput

0.536

High

573921

ML12A
Myosin regulatory light chain 12A

1

20

High-throughput

0.536

High

573923

MYL9
Myosin regulatory light polypeptide 9

1

20

High-throughput

0.536

High

573929

MYH10
Myosin-10

1

19

High-throughput

0.536

High

573934

CAZA2
F-actin-capping protein subunit alpha-2

1

3

High-throughput

0.536

High

573940

CDC42
Cell division control protein 42 homolog

1

12

High-throughput

0.536

High

573952

MYO9B
Unconventional myosin-IXb

1

18

High-throughput

0.536

High

573982

MYO19
Unconventional myosin-XIX

1

20

High-throughput

0.536

High

573998

PDLI7
PDZ and LIM domain protein 7

1

3

High-throughput

0.536

High

574002

MYO6
Unconventional myosin-VI

1

20

High-throughput

0.536

High

574001

DUX4
Double homeobox protein 4

1

4

High-throughput

0.516

High

574003

NCKP1
Nck-associated protein 1

1

0

High-throughput

0.513

High

573920

ATF3
Cyclic AMP-dependent transcription factor ATF-3

1

9

High-throughput

0.489

High

73991

MYO9A
Unconventional myosin-IXa

1

20

High-throughput

0.479

High

126453

RHOD
Rho-related GTP-binding protein RhoD

1

16

High-throughput

0.479

High

156909

CTRO
Citron Rho-interacting kinase

1

9

High-throughput

0.479

High

222684

PRC1
Protein regulator of cytokinesis 1

1

6

High-throughput

0.479

High

323150

TRI37
E3 ubiquitin-protein ligase TRIM37

1

6

High-throughput

0.479

High

370534

FOS
Protein c-Fos

1

5

High-throughput

0.479

High

400225

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.479

High

425290

ISG15
Ubiquitin-like protein ISG15

1

10

High-throughput

0.479

High

534580

BIP
Endoplasmic reticulum chaperone BiP

1

4

High-throughput

0.479

High

573922

BTF3
Transcription factor BTF3

1

3

High-throughput

0.479

High

573932

YAP1
Transcriptional coactivator YAP1

1

4

High-throughput

0.479

High

573938

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

5

High-throughput

0.479

High

573942

RHOB
Rho-related GTP-binding protein RhoB

1

15

High-throughput

0.479

High

573946

OCRL
Inositol polyphosphate 5-phosphatase OCRL

1

1

High-throughput

0.479

High

573949

FOXO1
Forkhead box protein O1

1

1

High-throughput

0.479

High

573950

TFCP2
Alpha-globin transcription factor CP2

1

1

High-throughput

0.479

High

573951

DC1I2
Cytoplasmic dynein 1 intermediate chain 2

1

1

High-throughput

0.479

High

573953

CUL1
Cullin-1

1

7

High-throughput

0.479

High

573954

CUL3
Cullin-3

1

7

High-throughput

0.479

High

573955

ARHG7
Rho guanine nucleotide exchange factor 7

1

2

High-throughput

0.479

High

573957

TNIP1
TNFAIP3-interacting protein 1

1

20

High-throughput

0.479

High

573958

KIF14
Kinesin-like protein KIF14

1

7

High-throughput

0.479

High

573962

LARP7
La-related protein 7

1

2

High-throughput

0.479

High

573963

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

3

High-throughput

0.479

High

573964

OTU1
Ubiquitin thioesterase OTU1

1

1

High-throughput

0.479

High

573965

FGD5
FYVE, RhoGEF and PH domain-containing protein 5

1

6

High-throughput

0.479

High

573968

MYH14
Myosin-14

1

18

High-throughput

0.479

High

573969

ARHG8
Neuroepithelial cell-transforming gene 1 protein

1

8

High-throughput

0.479

High

573970

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

2

High-throughput

0.479

High

573971

SLN11
Schlafen family member 11

1

1

Small-scale

0.479

High

573979

ASB11
Ankyrin repeat and SOCS box protein 11

1

1

High-throughput

0.479

High

573981

FBXW7
F-box/WD repeat-containing protein 7

1

2

High-throughput

0.479

High

573987

MEP50
Methylosome protein WDR77

1

6

High-throughput

0.479

High

573988

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

4

High-throughput

0.479

High

573990

CCDC8
Coiled-coil domain-containing protein 8

1

3

High-throughput

0.479

High

573991

CHM4B
Charged multivesicular body protein 4b

1

2

High-throughput

0.479

High

573993

ECT2
Protein ECT2

1

7

High-throughput

0.479

High

573994

RHOF
Rho-related GTP-binding protein RhoF

1

16

High-throughput

0.479

High

573999

RNF12
E3 ubiquitin-protein ligase RLIM

1

7

High-throughput

0.479

High

574000

HDAC6
Protein deacetylase HDAC6

1

5

High-throughput

0.479

High

574005

RIPK3
Receptor-interacting serine/threonine-protein kinase 3

1

12

High-throughput

0.479

High

413115

P53
Cellular tumor antigen p53

1

0

Small-scale

0.458

High

573919

H2AX
Histone H2AX

1

0

High-throughput

0.458

High

573925

DPOD1
DNA polymerase delta catalytic subunit

1

0

High-throughput

0.458

High

573927

PHB1
Prohibitin 1

1

0

High-throughput

0.458

High

573931

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

0

High-throughput

0.458

High

573935

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.458

High

573936

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

0

High-throughput

0.458

High

573945

MDM2
E3 ubiquitin-protein ligase Mdm2

1

0

Small-scale

0.458

High

573948

TF65
Transcription factor p65

1

0

High-throughput

0.458

High

573973

CEP57
Centrosomal protein of 57 kDa

1

0

High-throughput

0.458

High

573978

CEP76
Centrosomal protein of 76 kDa

1

0

High-throughput

0.458

High

573996

NGB
Neuroglobin

1

0

High-throughput

0.458

High

574004

FARP1
FERM, ARHGEF and pleckstrin domain-containing protein 1

1

0

High-throughput

0.458

High

516305

CALM1
Calmodulin-1

1

17

High-throughput

0.445

High

516379

CALM2
Calmodulin-2

1

17

High-throughput

0.445

High

516461

CALM3
Calmodulin-3

1

17

High-throughput

0.445

High

528994

TAU
Microtubule-associated protein tau

1

7

High-throughput

0.445

High

563118

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.445

High

573917

MYL6B
Myosin light chain 6B

1

17

High-throughput

0.445

High

573924

S10A4
Protein S100-A4

1

3

High-throughput

0.445

High

573926

BMI1
Polycomb complex protein BMI-1

1

6

High-throughput

0.445

High

573941

UBP46
Ubiquitin carboxyl-terminal hydrolase 46

1

1

High-throughput

0.445

High

573944

RHOG
Rho-related GTP-binding protein RhoG

1

12

Small-scale

0.445

High

573984

CEP63
Centrosomal protein of 63 kDa

1

20

High-throughput

0.445

High

573985

CK5P2
CDK5 regulatory subunit-associated protein 2

1

20

High-throughput

0.445

High

105251

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

293148

CD123
Translation initiation factor eIF2 assembly protein

1

2

High-throughput

0.437

High

315079

RECQ4
ATP-dependent DNA helicase Q4

1

1

High-throughput

0.437

High

318602

RHBT1
Rho-related BTB domain-containing protein 1

1

17

High-throughput

0.437

High

324491

HEXI1
Protein HEXIM1

1

1

High-throughput

0.437

High

330628

KI20A
Kinesin-like protein KIF20A

1

12

High-throughput

0.437

High

371063

MYC
Myc proto-oncogene protein

1

6

High-throughput

0.437

High

377942

TNFA
Tumor necrosis factor

1

2

High-throughput

0.437

High

405750

MYCN
N-myc proto-oncogene protein

1

6

High-throughput

0.437

High

464782

SP1
Transcription factor Sp1

1

2

Small-scale

0.437

High

573937

R144A
E3 ubiquitin-protein ligase RNF144A

1

2

Small-scale

0.437

High

573959

BRD3
Bromodomain-containing protein 3

1

1

High-throughput

0.437

High

573961

RHOH
Rho-related GTP-binding protein RhoH

1

15

High-throughput

0.437

High

573966

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.437

High

573967

MEPCE
7SK snRNA methylphosphate capping enzyme

1

1

High-throughput

0.437

High

573974

S35F2
Solute carrier family 35 member F2

1

1

Small-scale

0.437

High

573975

EMC5
ER membrane protein complex subunit 5

1

1

High-throughput

0.437

High

573976

FHI1B
FHF complex subunit HOOK-interacting protein 1B

1

1

High-throughput

0.437

High

573983

RHOV
Rho-related GTP-binding protein RhoV

1

14

High-throughput

0.437

High

573986

RING2
E3 ubiquitin-protein ligase RING2

1

3

High-throughput

0.437

High

573989

RHBT2
Rho-related BTB domain-containing protein 2

1

16

High-throughput

0.437

High

573992

PKHA4
Pleckstrin homology domain-containing family A member 4

1

15

High-throughput

0.437

High

254780

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

9

High-throughput

0.407

High

429231

JUN
Transcription factor Jun

1

3

High-throughput

0.407

High

573947

TAGL
Transgelin

1

20

High-throughput

0.407

High

573995

TPC
Mitochondrial thiamine pyrophosphate carrier

1

3

High-throughput

0.407

High

573960

SP17
Sperm surface protein Sp17

6

0

High-throughput

0.385

High

573918

TFE2
Transcription factor E2-alpha

1

0

High-throughput

0.249

Low

573930

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

0

High-throughput

0.249

Low

573956

RBM39
RNA-binding protein 39

1

0

High-throughput

0.249

Low

573977

DTX3
Probable E3 ubiquitin-protein ligase DTX3

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025