HitPredict

Interactor 1: H33 (P84243)
Histone H3.3
Gene: H3-3A

Interactor 2: SP16H (Q9Y5B9)
FACT complex subunit SPT16 (Chromatin-specific transcription elongation factor 140 kDa subunit) (FACT 140 kDa subunit) (FACTp140) (Facilitates chromatin transcription complex subunit SPT16) (hSPT16)
Gene: SUPT16H

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.847

Property	Details
Experiments	33961781, 36089195, 17403666
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Histone~Rtt106
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006334 - nucleosome assembly
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 136 Hs			1 1047
+	Hs
		935430 H31_HUMAN (1-136): 3.08e-60: 183: 96.32		SP16H_HUMAN (1-1047): 0: 1331: 100.00
+	Mm
		952764 H33_MOUSE (1-136): 1.12e-59: 182: 100.00		SP16H_MOUSE (1-1047): 0: 1332: 98.66
+	Hs
		1174703 H32_HUMAN (1-136): 5.32e-59: 180: 97.06		SP16H_HUMAN (1-1047): 0: 1331: 100.00
+	Hs
		1157245 H3C_HUMAN (1-136): 1.99e-56: 173: 95.59		SP16H_HUMAN (1-1047): 0: 1331: 100.00
+	Hs
		828435 CENPA_HUMAN (9-133): 2.42e-45: 146: 50.76		SP16H_HUMAN (1-1047): 0: 1331: 100.00
+	Sp
		292839 H31_SCHPO (1-136): 1.12e-57: 177: 91.91		SPT16_SCHPO (3-1016): 0: 1010: 37.43
+	Sp
		292845 CENPA_SCHPO (26-133): 9.54e-42: 136: 63.16		SPT16_SCHPO (3-1016): 0: 1010: 37.43
+	Sc
		692869 H3_YEAST (1-136): 3.62e-54: 168: 90.44		SPT16_YEAST (3-1008): 0: 938: 33.49
+	Sc
		692744 CENPA_YEAST (18-134): 3.39e-40: 135: 56.67		SPT16_YEAST (3-1008): 0: 938: 33.49