Protein: TYB4
Thymosin beta-4 (T beta-4) (Fx) [Cleaved into: Hemoregulatory peptide AcSDKP (Ac-Ser-Asp-Lys-Pro) (N-acetyl-SDKP) (AcSDKP) (Seraspenide)]

Gene: TYB4, TMSB4X
Organism: Homo sapiens
Interactions: 82
UniProt ID: P62328

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0003785 - actin monomer binding
GO:0005576 - extracellular region
GO:0005634 - nucleus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

974923

ACTS
Actin, alpha skeletal muscle

3

5

Small-scale

0.840

High

974918

ACTG
Actin, cytoplasmic 2

3

6

Small-scale

0.827

High

952715

ACTB
Actin, cytoplasmic 1

2

6

High-throughput

0.754

High

974933

K1H1
Keratin, type I cuticular Ha1

3

9

High-throughput

0.654

High

974920

TYB10
Thymosin beta-10

3

2

High-throughput

0.640

High

827367

MLH1
DNA mismatch repair protein Mlh1

2

0

Small-scale

0.619

High

974919

ACTH
Actin, gamma-enteric smooth muscle

1

6

High-throughput

0.618

High

974921

ACTC
Actin, alpha cardiac muscle 1

1

5

High-throughput

0.618

High

974939

ACTBL
Beta-actin-like protein 2

1

6

High-throughput

0.618

High

300332

KRT34
Keratin, type I cuticular Ha4

2

9

High-throughput

0.606

High

300560

KRT36
Keratin, type I cuticular Ha6

2

9

High-throughput

0.606

High

974931

FHL3
Four and a half LIM domains protein 3

2

1

High-throughput

0.606

High

269171

HSF2B
Heat shock factor 2-binding protein

2

0

High-throughput

0.580

High

974946

KRA81
Keratin-associated protein 8-1

2

0

High-throughput

0.580

High

974949

UHMK1
Serine/threonine-protein kinase Kist

2

0

High-throughput

0.580

High

974964

AKP8L
A-kinase anchor protein 8-like

2

0

High-throughput

0.580

High

974927

CAV1
Caveolin-1

2

1

High-throughput

0.571

High

974928

HSF2
Heat shock factor protein 2

1

1

High-throughput

0.536

High

421865

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.515

High

187327

SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

1

0

High-throughput

0.513

High

563004

MYH6
Myosin-6

1

0

High-throughput

0.513

High

974950

ZN526
Zinc finger protein 526

1

0

High-throughput

0.513

High

238472

RAD21
Double-strand-break repair protein rad21 homolog

1

0

High-throughput

0.486

High

405434

KITH
Thymidine kinase, cytosolic

1

0

High-throughput

0.486

High

627950

ANXA7
Annexin A7

1

0

High-throughput

0.486

High

808009

CDN1A
Cyclin-dependent kinase inhibitor 1

1

0

High-throughput

0.486

High

974932

GRB7
Growth factor receptor-bound protein 7

1

0

High-throughput

0.486

High

974937

SMN
Survival motor neuron protein

1

0

High-throughput

0.486

High

974961

TAF1D
TATA box-binding protein-associated factor RNA polymerase I subunit D

1

0

High-throughput

0.486

High

560845

HEM1
5-aminolevulinate synthase, non-specific, mitochondrial

1

1

High-throughput

0.481

High

566255

K1C13
Keratin, type I cytoskeletal 13

1

5

High-throughput

0.481

High

571920

TRI27
Zinc finger protein RFP

1

1

High-throughput

0.481

High

618016

K1C15
Keratin, type I cytoskeletal 15

1

5

High-throughput

0.481

High

783217

TRI23
E3 ubiquitin-protein ligase TRIM23

1

1

High-throughput

0.481

High

974935

TRIP6
Thyroid receptor-interacting protein 6

1

1

High-throughput

0.481

High

974941

K1C40
Keratin, type I cytoskeletal 40

1

9

High-throughput

0.481

High

974948

PNMA1
Paraneoplastic antigen Ma1

1

1

High-throughput

0.481

High

974954

RBPMS
RNA-binding protein with multiple splicing

1

1

High-throughput

0.481

High

974926

HSF1
Heat shock factor protein 1

1

1

High-throughput

0.479

High

974938

GRAP1
GRIP1-associated protein 1

1

1

High-throughput

0.479

High

974945

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.479

High

974947

GCC2
GRIP and coiled-coil domain-containing protein 2

1

1

High-throughput

0.479

High

974960

UACA
Uveal autoantigen with coiled-coil domains and ankyrin repeats

1

3

High-throughput

0.479

High

974962

RAI14
Ankycorbin

1

2

High-throughput

0.479

High

136868

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

0

High-throughput

0.458

High

875900

TCPE
T-complex protein 1 subunit epsilon

1

0

High-throughput

0.458

High

158646

TYB4Y
Thymosin beta-4, Y-chromosomal

1

0

High-throughput

0.458

High

170055

AURKA
Aurora kinase A

1

0

High-throughput

0.458

High

314949

DDAH1
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1

1

0

High-throughput

0.458

High

516757

SCHI1
Schwannomin-interacting protein 1

1

0

High-throughput

0.458

High

550961

PCNA
Proliferating cell nuclear antigen

1

0

High-throughput

0.458

High

582737

EZRI
Ezrin

1

0

High-throughput

0.458

High

853969

KI67
Proliferation marker protein Ki-67

1

0

High-throughput

0.458

High

974934

MED1
Mediator of RNA polymerase II transcription subunit 1

1

0

High-throughput

0.458

High

974936

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.458

High

974942

PKN3
Serine/threonine-protein kinase N3

1

0

High-throughput

0.458

High

974943

ZC3HE
Zinc finger CCCH domain-containing protein 14

1

0

High-throughput

0.458

High

974944

RICTR
Rapamycin-insensitive companion of mTOR

1

0

High-throughput

0.458

High

974953

NALP7
NACHT, LRR and PYD domains-containing protein 7

1

0

High-throughput

0.458

High

974958

TMPSD
Transmembrane protease serine 13

1

0

High-throughput

0.458

High

974959

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.458

High

413549

P53
Cellular tumor antigen p53

1

0

High-throughput

0.438

High

974922

EF1A1
Elongation factor 1-alpha 1

1

0

High-throughput

0.438

High

974929

TLE1
Transducin-like enhancer protein 1

1

0

High-throughput

0.438

High

974930

U119A
Protein unc-119 homolog A

1

0

High-throughput

0.438

High

974940

RIF1
Telomere-associated protein RIF1

1

0

High-throughput

0.438

High

974952

STAB2
Stabilin-2

1

0

Small-scale

0.438

High

529529

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.426

High

563553

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.426

High

598718

ANFB
Natriuretic peptides B

1

0

High-throughput

0.426

High

765329

BMI1
Polycomb complex protein BMI-1

1

0

High-throughput

0.426

High

942533

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

0

High-throughput

0.426

High

974924

RAE1L
mRNA export factor RAE1

1

0

High-throughput

0.426

High

974925

RHOG
Rho-related GTP-binding protein RhoG

1

0

Small-scale

0.426

High

974955

FBX17
F-box only protein 17

1

0

High-throughput

0.426

High

907303

APLP1
Amyloid beta precursor like protein 1

1

1

High-throughput

0.417

High

65030

GG6L9
Golgin subfamily A member 6-like protein 9

2

0

High-throughput

0.316

High

974965

COG6
Conserved oligomeric Golgi complex subunit 6

2

0

High-throughput

0.316

High

974957

F118B
Protein FAM118B

1

0

High-throughput

0.265

Low

974951

DNJB3
DnaJ homolog subfamily B member 3

1

0

High-throughput

0.249

Low

974956

IGS21
Immunoglobulin superfamily member 21

1

0

High-throughput

0.238

Low

974963

OGDHL
2-oxoglutarate dehydrogenase-like, mitochondrial

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025