HitPredict

Interactor 1: P91404 (P91404)
RING-type domain-containing protein
Gene: rbx-2

Interactor 2: CUL5 (Q23639)
Cullin-5 (CUL-5)
Gene: cul-5

Species: Caenorhabditis elegans

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.43	1.00	0.656

Property	Details
Experiments	17184777
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Cullin~zf-rbx1, Cullin_Nedd8~zf-rbx1
Common GO terms	GO:0016567 - protein ubiquitination GO:0031466 - Cul5-RING ubiquitin ligase complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 112 Ce			1 765
+	Hs
		921251 RBX1_HUMAN (1-111): 1.15e-38: 127: 37.39		CUL1_HUMAN (1-765): 0: 754: 27.85
+	Mm
		921509 RBX1_MOUSE (1-111): 1.15e-38: 127: 37.39		CUL1_MOUSE (1-765): 0: 754: 27.85
+	Ce
		1095356 RBX1_CAEEL (11-111): 2.02e-37: 124: 38.10		CUL5_CAEEL (1-765): 0: 728: 100.00
+	At
		1275966 RBX1A_ARATH (10-111): 5.62e-37: 122: 37.74		CUL3A_ARATH (4-765): 0: 728: 22.89
+	Mm
		921499 RBX1_MOUSE (1-111): 1.15e-38: 127: 37.39		CUL4A_MOUSE (5-765): 0: 719: 24.08
+	Hs
		921254 RBX1_HUMAN (1-111): 1.15e-38: 127: 37.39		CUL4A_HUMAN (5-765): 0: 718: 24.08
+	Hs
		921253 RBX1_HUMAN (1-111): 1.15e-38: 127: 37.39		CUL3_HUMAN (6-765): 0: 717: 19.70
+	Mm
		56790 RBX1_MOUSE (1-111): 1.15e-38: 127: 37.39		CUL4B_MOUSE (4-765): 0: 711: 24.97
+	Hs
		921255 RBX1_HUMAN (1-111): 1.15e-38: 127: 37.39		CUL4B_HUMAN (4-765): 0: 711: 24.97
+	At
		1275962 RBX1A_ARATH (10-111): 5.62e-37: 122: 37.74		CUL3B_ARATH (4-765): 0: 715: 22.37
+	Hs
		921374 RBX1_HUMAN (1-111): 1.15e-38: 127: 37.39		CUL5_HUMAN (1-765): 0: 688: 50.52
+	Dm
		1213855 RBX1A_DROME (12-111): 2.15e-38: 126: 37.50		Q8IP45_DROME (4-765): 0: 686: 19.52
+	Hs
		921252 RBX1_HUMAN (1-111): 1.15e-38: 127: 37.39		CUL2_HUMAN (1-765): 0: 682: 25.39
+	Dm
		1097212 RBX1A_DROME (12-111): 2.15e-38: 126: 37.50		CUL1_DROME (1-765): 0: 682: 27.03
+	Dm
		1124381 RBX1A_DROME (12-111): 2.15e-38: 126: 37.50		Q5BI50_DROME (5-765): 0: 679: 23.63
+	Dm
		1097197 RBX1B_DROME (8-112): 7.97e-37: 122: 39.82		CUL1_DROME (1-765): 0: 682: 27.03
+	At
		1275960 RBX1A_ARATH (10-111): 5.62e-37: 122: 37.74		CUL1_ARATH (1-765): 0: 679: 22.22
+	At
		1228140 RBX1A_ARATH (10-111): 5.62e-37: 122: 37.74		CUL4_ARATH (4-765): 0: 668: 22.85
+	Dm
		1360503 RBX1A_DROME (12-111): 2.15e-38: 126: 37.50		Q9V9R2_DROME (1-765): 0: 617: 23.39
+	Ce
		1088871 RBX1_CAEEL (11-111): 2.02e-37: 124: 38.10		CUL2_CAEEL (1-765): 0: 613: 24.26