Protein: KPRB
Phosphoribosyl pyrophosphate synthase-associated protein 2 (PRPP synthase-associated protein 2) (41 kDa phosphoribosypyrophosphate synthetase-associated protein) (PAP41)

Gene: KPRB, PRPSAP2
Organism: Homo sapiens
Interactions: 103
UniProt ID: O60256

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0004857 - enzyme inhibitor activity
GO:0005737 - cytoplasm
GO:0006015 - 5-phosphoribose 1-diphosphate biosynthetic process
GO:0006139 - nucleobase-containing compound metabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

240072

PRPS1
Ribose-phosphate pyrophosphokinase 1

7

17

High-throughput

0.964

High

240046

PRPS2
Ribose-phosphate pyrophosphokinase 2

6

17

High-throughput

0.944

High

240089

KPRA
Phosphoribosyl pyrophosphate synthase-associated protein 1

6

16

High-throughput

0.944

High

240056

PRPS3
Ribose-phosphate pyrophosphokinase 3

3

16

High-throughput

0.855

High

240027

KPRB
Phosphoribosyl pyrophosphate synthase-associated protein 2

2

16

High-throughput

0.783

High

240126

NS1BP
Influenza virus NS1A-binding protein

2

4

High-throughput

0.628

High

240048

CCNB1
G2/mitotic-specific cyclin-B1

2

0

High-throughput

0.602

High

240075

1433E
14-3-3 protein epsilon

2

3

Small-scale

0.601

High

240107

LZTR1
Leucine-zipper-like transcriptional regulator 1

2

7

High-throughput

0.574

High

240115

SNAG
Gamma-soluble NSF attachment protein

2

4

High-throughput

0.574

High

193158

SOCS1
Suppressor of cytokine signaling 1

2

14

High-throughput

0.571

High

240030

DOK2
Docking protein 2

2

4

High-throughput

0.571

High

240031

SH3L1
Adapter SH3BGRL

2

3

High-throughput

0.571

High

240049

VAV
Proto-oncogene vav

2

3

High-throughput

0.571

High

240051

NCK1
SH2/SH3 adapter protein NCK1

2

14

High-throughput

0.571

High

240052

KPCA
Protein kinase C alpha type

2

10

High-throughput

0.571

High

240054

RAB5A
Ras-related protein Rab-5A

2

3

High-throughput

0.571

High

240055

RASA1
Ras GTPase-activating protein 1

2

3

High-throughput

0.571

High

240073

CDC42
Cell division control protein 42 homolog

2

8

High-throughput

0.571

High

240076

RAC1
Ras-related C3 botulinum toxin substrate 1

2

7

High-throughput

0.571

High

240078

KPCE
Protein kinase C epsilon type

2

10

High-throughput

0.571

High

240081

PTN12
Tyrosine-protein phosphatase non-receptor type 12

2

3

High-throughput

0.571

High

240085

PAK1
Serine/threonine-protein kinase PAK 1

2

4

High-throughput

0.571

High

240086

MK07
Mitogen-activated protein kinase 7

2

9

High-throughput

0.571

High

240029

MAST3
Microtubule-associated serine/threonine-protein kinase 3

1

6

High-throughput

0.536

High

240111

CSN5
COP9 signalosome complex subunit 5

1

7

High-throughput

0.536

High

240113

UBP47
Ubiquitin carboxyl-terminal hydrolase 47

1

5

High-throughput

0.536

High

240039

KPCG
Protein kinase C gamma type

2

11

High-throughput

0.521

High

240041

FYN
Tyrosine-protein kinase Fyn

2

11

High-throughput

0.521

High

240042

HCK
Tyrosine-protein kinase HCK

2

11

High-throughput

0.521

High

240059

ELK4
ETS domain-containing protein Elk-4

2

5

High-throughput

0.521

High

240060

PEBP1
Phosphatidylethanolamine-binding protein 1

2

1

High-throughput

0.521

High

240066

PAXI
Paxillin

2

5

High-throughput

0.521

High

240070

CAV2
Caveolin-2

2

7

High-throughput

0.521

High

240079

CAV1
Caveolin-1

2

7

High-throughput

0.521

High

240092

KPCD1
Serine/threonine-protein kinase D1

2

14

High-throughput

0.521

High

240103

ABI1
Abl interactor 1

2

3

High-throughput

0.521

High

240106

SH2D3
SH2 domain-containing protein 3C

2

16

High-throughput

0.521

High

240077

RL19
Large ribosomal subunit protein eL19

1

0

High-throughput

0.513

High

240088

CAPR1
Caprin-1

1

0

High-throughput

0.513

High

240112

DCNL1
DCN1-like protein 1

1

0

High-throughput

0.513

High

240123

RTCB
RNA-splicing ligase RtcB homolog

1

0

High-throughput

0.513

High

240038

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.501

High

240043

PARP1
Poly [ADP-ribose] polymerase 1

1

4

High-throughput

0.489

High

240045

TOP1
DNA topoisomerase 1

1

2

High-throughput

0.489

High

240057

CBL
E3 ubiquitin-protein ligase CBL

1

1

High-throughput

0.489

High

240064

CAPZB
F-actin-capping protein subunit beta

1

2

High-throughput

0.489

High

240071

SNAA
Alpha-soluble NSF attachment protein

1

1

High-throughput

0.489

High

240084

SSRP1
FACT complex subunit SSRP1

1

2

High-throughput

0.489

High

240100

SFPA2
Pulmonary surfactant-associated protein A2

1

1

High-throughput

0.489

High

240122

NTNG1
Netrin-G1

1

1

High-throughput

0.489

High

240125

WIF1
Wnt inhibitory factor 1

1

1

High-throughput

0.489

High

240028

PRKN
E3 ubiquitin-protein ligase parkin

1

7

High-throughput

0.479

High

240032

CD123
Translation initiation factor eIF2 assembly protein

1

3

High-throughput

0.479

High

240034

RECQ4
ATP-dependent DNA helicase Q4

1

2

High-throughput

0.479

High

240035

SNAI1
Zinc finger protein SNAI1

1

3

High-throughput

0.479

High

240044

BIP
Endoplasmic reticulum chaperone BiP

1

2

High-throughput

0.479

High

240047

TCTP
Translationally-controlled tumor protein

1

1

High-throughput

0.479

High

240063

CCNF
Cyclin-F

1

3

High-throughput

0.479

High

240065

TISD
mRNA decay activator protein ZFP36L2

1

3

High-throughput

0.479

High

240069

CDK7
Cyclin-dependent kinase 7

1

5

High-throughput

0.479

High

240080

UBXN1
UBX domain-containing protein 1

1

3

High-throughput

0.479

High

240082

KPCZ
Protein kinase C zeta type

1

11

High-throughput

0.479

High

240090

SART3
Spliceosome associated factor 3, U4/U6 recycling protein

1

1

High-throughput

0.479

High

240098

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.479

High

240099

LYRIC
Protein LYRIC

1

1

Small-scale

0.479

High

240110

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

2

High-throughput

0.479

High

240116

ANM1
Protein arginine N-methyltransferase 1

1

2

High-throughput

0.479

High

240118

PKHA4
Pleckstrin homology domain-containing family A member 4

1

8

High-throughput

0.479

High

240119

PKHA2
Pleckstrin homology domain-containing family A member 2

1

3

Small-scale

0.479

High

240121

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

240124

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

5

Small-scale

0.479

High

240095

H2B2F
Histone H2B type 2-F

1

2

High-throughput

0.470

High

240036

NSD2
Histone-lysine N-methyltransferase NSD2

1

0

Small-scale

0.458

High

240033

PR15A
Protein phosphatase 1 regulatory subunit 15A

1

1

High-throughput

0.445

High

240053

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

6

High-throughput

0.445

High

240083

BTK
Tyrosine-protein kinase BTK

1

12

High-throughput

0.445

High

240096

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

3

High-throughput

0.445

High

240108

ENDOV
Endonuclease V

1

0

High-throughput

0.438

High

240037

NTRK1
High affinity nerve growth factor receptor

1

1

High-throughput

0.437

High

240050

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.437

High

240058

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.437

High

240062

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.437

High

240068

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

2

High-throughput

0.437

High

240074

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

4

High-throughput

0.437

High

240087

TIF1B
Transcription intermediary factor 1-beta

1

1

High-throughput

0.437

High

240091

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

4

High-throughput

0.437

High

240093

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

2

High-throughput

0.437

High

240094

EMC4
ER membrane protein complex subunit 4

1

3

High-throughput

0.437

High

240101

S35F2
Solute carrier family 35 member F2

1

2

Small-scale

0.437

High

240105

FBXL6
F-box/LRR-repeat protein 6

1

1

High-throughput

0.437

High

240117

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

1

High-throughput

0.437

High

240040

JUN
Transcription factor Jun

1

4

High-throughput

0.407

High

240097

PKHA7
Pleckstrin homology domain-containing family A member 7

1

9

High-throughput

0.407

High

240061

KAP1
cAMP-dependent protein kinase type I-beta regulatory subunit

2

0

High-throughput

0.328

High

240067

FNTB
Protein farnesyltransferase subunit beta

2

0

High-throughput

0.328

High

240104

GLT16
Polypeptide N-acetylgalactosaminyltransferase 16

2

0

High-throughput

0.328

High

240102

TEX11
Testis-expressed protein 11

2

0

High-throughput

0.316

High

240109

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

1

0

High-throughput

0.279

Low

240114

DOCK7
Dedicator of cytokinesis protein 7

1

0

High-throughput

0.279

Low

240120

VTI1B
Vesicle transport through interaction with t-SNAREs homolog 1B

1

0

High-throughput

0.279

Low

104911

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025