HitPredict

Interactor 1: 1433E (P92177)
14-3-3 protein epsilon (Suppressor of Ras1 3-9)
Gene: 14-3-3epsilon

Interactor 2: YAP1 (Q45VV3)
Transcriptional coactivator yorkie (Protein yorkie) (Transcriptional coactivator YAP1 homolog)
Gene: yki

Species: Drosophila melanogaster

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.82	0.60	0.703

Property	Details
Experiments	26887950, 25320084, 24114784, 19900439, 23263283
Identification Methods	affinity chromatography technology, protein complementation assay
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0040008 - regulation of growth and 1 others more... GO:0045927 - positive regulation of growth
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 262 Dm			1 395
+	Dm
		664610 1433Z_DROME (2-247): 5.14e-135: 382: 65.85		YAP1_DROME (1-395): 4.31e-94: 289: 100.00
+	Mm
		93264 1433E_MOUSE (1-261): 2.02e-147: 413: 82.38		E9PXB7_MOUSE (23-390): 8.4e-67: 228: 19.33
+	Hs
		808460 1433E_HUMAN (1-261): 2.02e-147: 413: 82.38		YAP1_HUMAN (32-343): 1.31e-53: 187: 30.03
+	Rn
		910358 1433E_RAT (1-261): 2.02e-147: 413: 82.38		NEDD4_RAT (7-308): 5.28e-33: 132: 15.89
+	Mm
		808343 1433E_MOUSE (1-261): 2.02e-147: 413: 82.38		NEDD4_MOUSE (7-308): 1.2e-31: 129: 14.64
+	Hs
		909790 1433E_HUMAN (1-261): 2.02e-147: 413: 82.38		KIBRA_HUMAN (238-344): 1.5e-30: 126: 35.51
+	Hs
		909674 1433E_HUMAN (1-261): 2.02e-147: 413: 82.38		WWC2_HUMAN (233-344): 3.1e-30: 125: 30.97
+	Hs
		125318 1433E_HUMAN (1-261): 2.02e-147: 413: 82.38		WWP2_HUMAN (128-393): 9.36e-19: 90.6: 11.94
+	Hs
		808077 1433E_HUMAN (1-261): 2.02e-147: 413: 82.38		NEDD4_HUMAN (268-382): 1.51e-10: 65.1: 18.85
+	Hs
		910022 1433E_HUMAN (1-261): 2.02e-147: 413: 82.38		SAV1_HUMAN (106-381): 1.87e-10: 64: 14.29
+	Hs
		909930 1433E_HUMAN (1-261): 2.02e-147: 413: 82.38		NED4L_HUMAN (246-322): 8.24e-10: 62.8: 23.17
+	Mm
		910302 1433E_MOUSE (1-261): 2.02e-147: 413: 82.38		NED4L_MOUSE (246-322): 8.6e-09: 59.4: 25.30
+	Sc
		664848 BMH1_YEAST (2-235): 7.88e-111: 322: 76.60		RSP5_YEAST (31-300): 7.01e-29: 120: 13.67
+	Sc
		712922 BMH2_YEAST (4-235): 8.71e-110: 319: 76.40		RSP5_YEAST (31-300): 7.01e-29: 120: 13.67