Protein: DNJB2
DnaJ homolog subfamily B member 2 (Heat shock 40 kDa protein 3) (Heat shock protein J1) (HSJ-1)

Gene: DNJB2, DNAJB2
Organism: Homo sapiens
Interactions: 150
UniProt ID: P25686

Gene Ontology (top 5):
GO:0000502 - proteasome complex
GO:0001671 - ATPase activator activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005789 - endoplasmic reticulum membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

274473

DNJB6
DnaJ homolog subfamily B member 6

3

14

High-throughput

0.861

High

679376

DNJB8
DnaJ homolog subfamily B member 8

3

16

High-throughput

0.861

High

536530

HSP7C
Heat shock cognate 71 kDa protein

3

20

Small-scale

0.847

High

679307

HSP74
Heat shock 70 kDa protein 4

3

20

Small-scale

0.834

High

600739

HSP76
Heat shock 70 kDa protein 6

2

20

High-throughput

0.789

High

679318

HSP72
Heat shock-related 70 kDa protein 2

2

20

High-throughput

0.789

High

593634

BGAL
Beta-galactosidase

4

3

High-throughput

0.691

High

507547

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

3

12

Small-scale

0.679

High

507086

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

3

12

High-throughput

0.667

High

679331

TROP
Trophinin

3

2

High-throughput

0.667

High

679332

TRAF2
TNF receptor-associated factor 2

3

3

High-throughput

0.667

High

679337

BIRC2
Baculoviral IAP repeat-containing protein 2

3

4

High-throughput

0.667

High

679353

RFWD3
E3 ubiquitin-protein ligase RFWD3

3

3

High-throughput

0.667

High

679356

RN19B
E3 ubiquitin-protein ligase RNF19B

3

4

High-throughput

0.667

High

679359

FA83H
Protein FAM83H

3

1

High-throughput

0.667

High

679387

DNJC7
DnaJ homolog subfamily C member 7

1

20

High-throughput

0.665

High

679404

RNF12
E3 ubiquitin-protein ligase RLIM

3

8

High-throughput

0.662

High

679375

PJA1
E3 ubiquitin-protein ligase Praja-1

3

5

High-throughput

0.650

High

679417

RN115
E3 ubiquitin-protein ligase RNF115

3

5

High-throughput

0.650

High

679326

CSK21
Casein kinase II subunit alpha

1

2

Small-scale

0.647

High

679335

M3K1
Mitogen-activated protein kinase kinase kinase 1

1

3

Small-scale

0.647

High

679370

LACC1
Purine nucleoside phosphorylase LACC1

3

0

High-throughput

0.638

High

679406

NSE4A
Non-structural maintenance of chromosomes element 4 homolog A

3

0

High-throughput

0.638

High

528662

PPGB
Lysosomal protective protein

4

2

High-throughput

0.630

High

563225

CFTR
Cystic fibrosis transmembrane conductance regulator

2

7

High-throughput

0.628

High

279118

ULK1
Serine/threonine-protein kinase ULK1

1

4

Small-scale

0.618

High

343900

HS74L
Heat shock 70 kDa protein 4L

1

20

High-throughput

0.618

High

679306

HS71L
Heat shock 70 kDa protein 1-like

1

20

High-throughput

0.618

High

679311

HSPA9
Stress-70 protein, mitochondrial

1

20

High-throughput

0.618

High

679316

NEK4
Serine/threonine-protein kinase Nek4

1

6

High-throughput

0.618

High

679320

MLF1
Myeloid leukemia factor 1

2

12

High-throughput

0.611

High

679330

ATP7A
Copper-transporting ATPase 1

2

2

High-throughput

0.611

High

516181

HS71B
Heat shock 70 kDa protein 1B

1

20

High-throughput

0.575

High

679418

KCTD3
BTB/POZ domain-containing protein KCTD3

2

10

High-throughput

0.558

High

679346

Q53FC7
Heat shock 70 kDa protein 6

1

20

High-throughput

0.553

High

679380

Q96BE0
Heat shock cognate 71 kDa protein

1

20

High-throughput

0.553

High

171055

VP26C
Vacuolar protein sorting-associated protein 26C

1

1

High-throughput

0.541

High

582072

PGAM2
Phosphoglycerate mutase 2

1

1

High-throughput

0.536

High

679341

BLTP2
Bridge-like lipid transfer protein family member 2

1

1

High-throughput

0.536

High

679361

UBP34
Ubiquitin carboxyl-terminal hydrolase 34

1

4

High-throughput

0.536

High

679362

TBA1A
Tubulin alpha-1A chain

1

9

High-throughput

0.536

High

679381

HDA11
Histone deacetylase 11

1

12

High-throughput

0.536

High

679383

RN185
E3 ubiquitin-protein ligase RNF185

1

5

High-throughput

0.536

High

679395

ADT4
ADP/ATP translocase 4

1

1

High-throughput

0.536

High

679409

WRP73
WD repeat-containing protein WRAP73

1

5

High-throughput

0.536

High

679421

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

3

High-throughput

0.536

High

105371

APRIO
Alternative prion protein

2

1

High-throughput

0.533

High

517285

ZTRF1
Zinc finger TRAF-type-containing protein 1

2

0

High-throughput

0.528

High

679412

UBQL1
Ubiquilin-1

1

3

Small-scale

0.527

High

679340

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

19

High-throughput

0.515

High

679398

TM231
Transmembrane protein 231

1

4

High-throughput

0.515

High

679413

CHIP
E3 ubiquitin-protein ligase CHIP

1

17

High-throughput

0.515

High

679321

ACTB
Actin, cytoplasmic 1

1

0

High-throughput

0.513

High

679365

GET4
Golgi to ER traffic protein 4 homolog

1

0

High-throughput

0.513

High

679378

MY18A
Unconventional myosin-XVIIIa

1

0

High-throughput

0.513

High

679399

PAAT
ATPase PAAT

1

0

High-throughput

0.513

High

679400

MARH7
E3 ubiquitin-protein ligase MARCHF7

1

0

High-throughput

0.513

High

679403

DBLOH
Diablo IAP-binding mitochondrial protein

1

0

High-throughput

0.513

High

679336

SMAD4
Mothers against decapentaplegic homolog 4

1

3

High-throughput

0.508

High

679345

NEDD8
Ubiquitin-like protein NEDD8

1

2

Small-scale

0.501

High

679415

DHDH
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase

1

2

High-throughput

0.489

High

679377

FBX25
F-box only protein 25

1

0

Small-scale

0.480

High

293225

CD123
Translation initiation factor eIF2 assembly protein

1

5

High-throughput

0.479

High

343222

ERR2
Steroid hormone receptor ERR2

1

13

High-throughput

0.479

High

346861

BAG2
BAG family molecular chaperone regulator 2

1

10

High-throughput

0.479

High

425317

ISG15
Ubiquitin-like protein ISG15

1

16

Small-scale

0.479

High

468089

HS90B
Heat shock protein HSP 90-beta

1

8

High-throughput

0.479

High

616258

RCC1
Regulator of chromosome condensation

1

3

High-throughput

0.479

High

679303

SYTC
Threonine--tRNA ligase 1, cytoplasmic

1

1

High-throughput

0.479

High

679304

PML
Protein PML

1

5

High-throughput

0.479

High

679305

STIP1
Stress-induced-phosphoprotein 1

1

17

High-throughput

0.479

High

679310

SRP14
Signal recognition particle 14 kDa protein

1

3

High-throughput

0.479

High

679322

PSA6
Proteasome subunit alpha type-6

1

1

Small-scale

0.479

High

679324

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

8

High-throughput

0.479

High

679325

GRB2
Growth factor receptor-bound protein 2

1

4

High-throughput

0.479

High

679327

RNF4
E3 ubiquitin-protein ligase RNF4

1

2

High-throughput

0.479

High

679333

TADBP
TAR DNA-binding protein 43

1

3

Small-scale

0.479

High

679334

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

1

High-throughput

0.479

High

679338

CUL3
Cullin-3

1

6

High-throughput

0.479

High

679343

MLF2
Myeloid leukemia factor 2

1

12

High-throughput

0.479

High

679348

RNF43
E3 ubiquitin-protein ligase RNF43

1

8

High-throughput

0.479

High

679355

LMBRL
Protein LMBR1L

1

2

High-throughput

0.479

High

679357

BAKOR
Beclin 1-associated autophagy-related key regulator

1

1

High-throughput

0.479

High

679372

BBS7
BBSome complex member BBS7

1

1

High-throughput

0.479

High

679379

ESR2
Estrogen receptor beta

1

13

High-throughput

0.479

High

679382

SEH1
Nucleoporin SEH1

1

7

High-throughput

0.479

High

679384

CI072
Guanine nucleotide exchange factor C9orf72

1

3

High-throughput

0.479

High

679392

TBB6
Tubulin beta-6 chain

1

6

High-throughput

0.479

High

679394

SPRTN
DNA-dependent metalloprotease SPRTN

1

2

High-throughput

0.479

High

679401

GRPE1
GrpE protein homolog 1, mitochondrial

1

6

High-throughput

0.479

High

679402

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

2

High-throughput

0.479

High

679411

BAG5
BAG family molecular chaperone regulator 5

1

15

High-throughput

0.479

High

679414

SNX6
Sorting nexin-6

1

7

High-throughput

0.479

High

679420

BIG2
Brefeldin A-inhibited guanine nucleotide-exchange protein 2

1

3

High-throughput

0.479

High

223984

GET3
ATPase GET3

1

0

High-throughput

0.458

High

679312

ARL1
ADP-ribosylation factor-like protein 1

1

0

High-throughput

0.458

High

679317

ATX3
Ataxin-3

1

0

Small-scale

0.458

High

679388

METH
Methionine synthase

1

0

High-throughput

0.458

High

679393

BBS2
BBSome complex member BBS2

1

0

High-throughput

0.458

High

161285

ENC1
Ectoderm-neural cortex protein 1

1

6

High-throughput

0.445

High

208464

PJA2
E3 ubiquitin-protein ligase Praja-2

1

4

High-throughput

0.445

High

290861

PPM1B
Protein phosphatase 1B

1

1

High-throughput

0.445

High

410632

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

11

High-throughput

0.445

High

442597

RB
Retinoblastoma-associated protein

1

1

High-throughput

0.445

High

529112

TAU
Microtubule-associated protein tau

1

3

High-throughput

0.445

High

679329

RUNX1
Runt-related transcription factor 1

1

3

High-throughput

0.445

High

679347

A16L1
Autophagy-related protein 16-1

1

14

High-throughput

0.445

High

679350

IQEC1
IQ motif and SEC7 domain-containing protein 1

1

3

High-throughput

0.445

High

679351

PKHA7
Pleckstrin homology domain-containing family A member 7

1

8

High-throughput

0.445

High

679354

SAMD1
Sterile alpha motif domain-containing protein 1

1

5

High-throughput

0.445

High

679368

TAXB1
Tax1-binding protein 1

1

3

High-throughput

0.445

High

679373

ASPM
Abnormal spindle-like microcephaly-associated protein

1

4

High-throughput

0.445

High

679374

VPS52
Vacuolar protein sorting-associated protein 52 homolog

1

2

High-throughput

0.445

High

679386

RUFY1
RUN and FYVE domain-containing protein 1

1

3

High-throughput

0.445

High

679389

RNF5
E3 ubiquitin-protein ligase RNF5

1

5

High-throughput

0.445

High

679416

ZN281
Zinc finger protein 281

1

8

High-throughput

0.445

High

465751

OPSD
Rhodopsin

1

2

Small-scale

0.437

High

679309

ATP7B
Copper-transporting ATPase 2

1

2

High-throughput

0.437

High

326514

MFN2
Mitofusin-2

1

0

High-throughput

0.426

High

404678

PRIO
Major prion protein

1

0

High-throughput

0.426

High

679308

TIMP3
Metalloproteinase inhibitor 3

1

0

High-throughput

0.426

High

679314

KNTC1
Kinetochore-associated protein 1

1

0

High-throughput

0.426

High

679315

DNA2
DNA replication ATP-dependent helicase/nuclease DNA2

1

0

High-throughput

0.426

High

679323

AP1S1
AP-1 complex subunit sigma-1A

1

0

High-throughput

0.426

High

679344

MSMO1
Methylsterol monooxygenase 1

1

0

High-throughput

0.426

High

679363

MON1B
Vacuolar fusion protein MON1 homolog B

1

0

High-throughput

0.426

High

679369

PTOV1
Prostate tumor-overexpressed gene 1 protein

1

0

High-throughput

0.426

High

679385

WRIP1
ATPase WRNIP1

1

0

High-throughput

0.426

High

679390

CYBC1
Cytochrome b-245 chaperone 1

1

0

High-throughput

0.426

High

679391

TIM29
Mitochondrial import inner membrane translocase subunit Tim29

1

0

High-throughput

0.426

High

679396

S35B3
Adenosine 3'-phospho 5'-phosphosulfate transporter 2

1

0

High-throughput

0.426

High

679339

PEBB
Core-binding factor subunit beta

1

1

High-throughput

0.407

High

679352

ZNT6
Zinc transporter 6

1

2

High-throughput

0.407

High

679360

TMTC3
Protein O-mannosyl-transferase TMTC3

1

20

High-throughput

0.407

High

679367

S47A2
Multidrug and toxin extrusion protein 2

1

1

High-throughput

0.407

High

679371

ZNT8
Proton-coupled zinc antiporter SLC30A8

1

2

High-throughput

0.407

High

679397

S2532
Solute carrier family 25 member 32

1

4

High-throughput

0.407

High

679407

UTP6
U3 small nucleolar RNA-associated protein 6 homolog

1

2

High-throughput

0.407

High

679408

MTCH1
Mitochondrial carrier homolog 1

1

4

High-throughput

0.407

High

679419

ORNT1
Mitochondrial ornithine transporter 1

1

4

High-throughput

0.407

High

679410

MO4L1
Mortality factor 4-like protein 1

1

0

High-throughput

0.249

Low

679313

CNDD3
Condensin-2 complex subunit D3

1

0

High-throughput

0.232

Low

679319

PEX3
Peroxisomal biogenesis factor 3

1

0

High-throughput

0.232

Low

679328

CCZ1B
Vacuolar fusion protein CCZ1 homolog B

1

0

High-throughput

0.232

Low

679342

SURF1
Surfeit locus protein 1

1

0

High-throughput

0.232

Low

679349

HEAT6
HEAT repeat-containing protein 6

1

0

High-throughput

0.232

Low

679358

SHLD3
Shieldin complex subunit 3

1

0

High-throughput

0.232

Low

679364

ARMX2
Armadillo repeat-containing X-linked protein 2

1

0

High-throughput

0.232

Low

679366

NIPA1
Magnesium transporter NIPA1

1

0

High-throughput

0.232

Low

679405

ARL15
ADP-ribosylation factor-like protein 15

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025