Interactor 1: MCL1 (P97287)
Induced myeloid leukemia cell differentiation protein Mcl-1 homolog (Bcl-2-related protein EAT/mcl1)
Gene: MCL1
Interactor 2: APR (Q9JM54)
Phorbol-12-myristate-13-acetate-induced protein 1 (Protein Noxa)
Gene: Pmaip1
Species: Mus musculus
Source: mint
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.86 | 1.00 | 0.932 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 23733106, 17389404, 15694340, 20627101, 18589438 |
| Identification Methods | affinity chromatography technology, nuclear magnetic resonance, isothermal titration calorimetry, anti tag coimmunoprecipitation, surface plasmon resonance, phage display, anti bait coimmunoprecipitation |
| Interaction Type | physical association, direct interaction |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | Bcl-2~PMAIP1 |
| Common GO terms | GO:0001836 - release of cytochrome c from mitochondria GO:0005739 - mitochondrion GO:0006974 - DNA damage response GO:0008630 - intrinsic apoptotic signaling pathway in response to DNA damage GO:0043065 - positive regulation of apoptotic process and 1 others more... |
| Homologous interactions | 7 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
