Protein: SRP54
Signal recognition particle subunit SRP54 (EC 3.6.5.4) (Signal recognition particle 54 kDa protein homolog)

Gene: SRP54
Organism: Saccharomyces cerevisiae S288C
Interactions: 202
UniProt ID: P20424

Gene Ontology (top 5):
GO:0003924 - GTPase activity
GO:0005096 - GTPase activator activity
GO:0005525 - GTP binding
GO:0005783 - endoplasmic reticulum
GO:0005786 - signal recognition particle, endoplasmic reticulum targeting

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

631867

SEC65
Signal recognition particle subunit SEC65

5

3

Small-scale

0.918

High

631913

SRP68
Signal recognition particle subunit SRP68

3

2

High-throughput

0.855

High

631878

SRPR
Signal recognition particle receptor subunit alpha homolog

2

11

Small-scale

0.726

High

631914

SRP72
Signal recognition particle subunit SRP72

5

3

Small-scale

0.706

High

631923

SRP14
Signal recognition particle subunit SRP14

5

0

High-throughput

0.682

High

631870

SRP21
Signal recognition particle subunit SRP21

4

0

High-throughput

0.664

High

149576

RS9A
Small ribosomal subunit protein uS4A

3

1

Small-scale

0.624

High

631930

BEM2
GTPase-activating protein BEM2/IPL2

2

0

High-throughput

0.595

High

631861

SRO9
RNA-binding protein SRO9

2

3

High-throughput

0.588

High

631874

GSP1
GTP-binding nuclear protein GSP1/CNR1

2

6

High-throughput

0.571

High

631877

RSSA1
Small ribosomal subunit protein uS2A

2

1

High-throughput

0.571

High

631995

SCC2
Sister chromatid cohesion protein 2

2

1

High-throughput

0.571

High

631882

LHP1
La protein homolog

2

2

High-throughput

0.567

High

444419

DED1
ATP-dependent RNA helicase DED1

1

1

Small-scale

0.561

High

525895

HSP72
Heat shock protein SSA2

2

4

High-throughput

0.552

High

631984

SLT2
Mitogen-activated protein kinase SLT2/MPK1

1

0

High-throughput

0.513

High

631998

KU80
ATP-dependent DNA helicase II subunit 2

1

0

High-throughput

0.513

High

631854

SEC22
Protein transport protein SEC22

1

1

Small-scale

0.501

High

631853

PUR6
Phosphoribosylaminoimidazole carboxylase

1

1

High-throughput

0.494

High

631868

XPO1
Exportin-1

1

2

High-throughput

0.489

High

631898

CAF4
CCR4-associated factor 4

1

1

High-throughput

0.489

High

632013

YTM1
Ribosome biogenesis protein YTM1

1

1

High-throughput

0.489

High

631929

RV167
Reduced viability upon starvation protein 167

1

0

Small-scale

0.486

High

631886

SEC66
Translocation protein SEC66

1

0

Small-scale

0.480

High

536072

ARF1
ADP-ribosylation factor 1

1

1

High-throughput

0.479

High

631857

SIS1
Protein SIS1

1

1

High-throughput

0.479

High

631859

RS2
Small ribosomal subunit protein uS5

1

1

High-throughput

0.479

High

631864

SPB4
ATP-dependent rRNA helicase SPB4

1

2

High-throughput

0.479

High

631869

HS104
Heat shock protein 104

1

1

High-throughput

0.479

High

631891

RS27A
Small ribosomal subunit protein eS27A

1

1

High-throughput

0.479

High

631899

GBLP
Small ribosomal subunit protein RACK1

1

2

High-throughput

0.479

High

631927

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.479

High

631954

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

1

High-throughput

0.479

High

433439

RL26A
Large ribosomal subunit protein uL24A

1

0

High-throughput

0.458

High

434813

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

435764

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.458

High

512810

RS8A
Small ribosomal subunit protein eS8A

1

0

High-throughput

0.458

High

569901

RL3
Large ribosomal subunit protein uL3

1

0

High-throughput

0.458

High

631883

RS3A1
Small ribosomal subunit protein eS1A

1

0

High-throughput

0.458

High

631888

UBX1
UBX domain-containing protein 1

1

0

Small-scale

0.458

High

631965

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.458

High

631983

NUM1
Nuclear migration protein NUM1

1

0

High-throughput

0.458

High

631985

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.458

High

631990

PEX29
Peroxisomal membrane protein PEX29

1

0

Small-scale

0.458

High

632004

PEX30
Peroxisomal membrane protein PEX30

1

0

Small-scale

0.458

High

632011

RS10A
Small ribosomal subunit protein eS10A

1

0

High-throughput

0.458

High

617961

DAP2
Dipeptidyl aminopeptidase B

1

1

Small-scale

0.457

High

367691

ENO1
Enolase 1

1

1

High-throughput

0.445

High

367889

ENO2
Enolase 2

1

1

High-throughput

0.445

High

386560

TBB
Tubulin beta chain

1

1

High-throughput

0.445

High

394226

EF1A
Elongation factor 1-alpha

1

1

High-throughput

0.445

High

441697

RS14A
Small ribosomal subunit protein uS11A

1

3

High-throughput

0.445

High

453415

PYR1
Multifunctional protein URA2

1

1

High-throughput

0.445

High

486022

TBA1
Tubulin alpha-1 chain

1

1

High-throughput

0.445

High

504031

RL31A
Large ribosomal subunit protein eL31A

1

2

Small-scale

0.445

High

513455

RL1A
Large ribosomal subunit protein uL1A

1

2

High-throughput

0.445

High

631871

MSS1
tRNA modification GTPase MSS1, mitochondrial

1

1

High-throughput

0.445

High

631872

HSP7F
Heat shock protein homolog SSE1

1

5

High-throughput

0.445

High

631875

GSP2
GTP-binding nuclear protein GSP2/CNR2

1

4

High-throughput

0.445

High

631892

YKT6
Synaptobrevin homolog YKT6

1

1

High-throughput

0.445

High

631915

RS27B
Small ribosomal subunit protein eS27B

1

1

High-throughput

0.445

High

631922

ALP1
Basic amino-acid permease

1

3

High-throughput

0.445

High

631925

RS14B
Small ribosomal subunit protein uS11B

1

3

High-throughput

0.445

High

631937

SSB2
Ribosome-associated molecular chaperone SSB2

1

3

High-throughput

0.445

High

631957

NMD5
Nonsense-mediated mRNA decay protein 5

1

1

High-throughput

0.445

High

631966

RL4B
Large ribosomal subunit protein uL4B

1

2

Small-scale

0.445

High

631981

ERG5
C-22 sterol desaturase ERG5

1

1

High-throughput

0.445

High

631987

YP113
Putative 2-hydroxyacid dehydrogenase YPL113C

1

1

High-throughput

0.445

High

631866

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.437

High

368586

PMG1
Phosphoglycerate mutase 1

1

0

High-throughput

0.426

High

383262

RL28
Large ribosomal subunit protein uL15

1

0

High-throughput

0.426

High

428019

PLMT
Phosphatidyl-N-methylethanolamine N-methyltransferase

1

0

High-throughput

0.426

High

434232

RL29
Large ribosomal subunit protein eL29

1

0

High-throughput

0.426

High

454702

KAPR
cAMP-dependent protein kinase regulatory subunit

1

0

High-throughput

0.426

High

559657

GAL3
Protein GAL3

1

0

High-throughput

0.426

High

618936

IRA2
Inhibitory regulator protein IRA2

1

0

High-throughput

0.426

High

631858

SED4
Putative guanine nucleotide-exchange factor SED4

1

0

High-throughput

0.426

High

631865

SEC20
Protein transport protein SEC20

1

0

High-throughput

0.426

High

631879

PRS7
26S proteasome regulatory subunit 7 homolog

1

0

High-throughput

0.426

High

631880

TKT2
Transketolase 2

1

0

High-throughput

0.426

High

631881

DHE2
NAD-specific glutamate dehydrogenase

1

0

High-throughput

0.426

High

631884

MSN4
Zinc finger protein MSN4

1

0

High-throughput

0.426

High

631932

NUG1
Nuclear GTP-binding protein NUG1

1

0

High-throughput

0.426

High

631946

LCB2
Serine palmitoyltransferase 2

1

0

High-throughput

0.426

High

631948

CIN1
Chromosome instability protein 1

1

0

High-throughput

0.426

High

631953

AGX1
Alanine--glyoxylate aminotransferase 1

1

0

High-throughput

0.426

High

631955

ROG3
Protein ROG3

1

0

High-throughput

0.426

High

631980

ALDH6
Magnesium-activated aldehyde dehydrogenase, cytosolic

1

0

High-throughput

0.426

High

631982

ACT
Actin

1

0

High-throughput

0.426

High

631988

GIP3
GLC7-interacting protein 3

1

0

High-throughput

0.426

High

631989

YD476
Uncharacterized protein YDR476C

1

0

High-throughput

0.426

High

632003

SGPL
Sphingosine-1-phosphate lyase

1

0

High-throughput

0.426

High

632008

THI3
Thiamine metabolism regulatory protein THI3

1

0

High-throughput

0.426

High

632021

CRM2
Homeostatic regulator of DAG

1

0

High-throughput

0.426

High

631856

PTP1
Tyrosine-protein phosphatase 1

1

2

High-throughput

0.407

High

631900

CDC27
Anaphase-promoting complex subunit CDC27

1

2

High-throughput

0.407

High

631903

MAL33
Maltose fermentation regulatory protein MAL33

1

1

High-throughput

0.407

High

631916

YHE9
Uncharacterized protein YHL049C

1

1

High-throughput

0.407

High

631920

CRG1
Probable S-adenosylmethionine-dependent methyltransferase CRG1

1

1

High-throughput

0.407

High

631924

DUN1
DNA damage response protein kinase DUN1

1

1

High-throughput

0.407

High

631928

SWD1
COMPASS component SWD1

1

1

High-throughput

0.407

High

631931

YEI6
Uncharacterized protein YEL076C

1

1

High-throughput

0.407

High

631947

HUL4
Probable E3 ubiquitin-protein ligase HUL4

1

1

High-throughput

0.407

High

631956

CHA4
Activatory protein CHA4

1

3

High-throughput

0.407

High

631974

MAL13
Maltose fermentation regulatory protein MAL13

1

1

High-throughput

0.407

High

631976

COPA
Coatomer subunit alpha

1

1

High-throughput

0.407

High

632020

YB11A
Transposon Ty1-BL Gag polyprotein

1

1

High-throughput

0.407

High

631919

NACA
Nascent polypeptide-associated complex subunit alpha

3

0

Small-scale

0.337

High

401878

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

High-throughput

0.249

Low

631855

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

0

High-throughput

0.249

Low

631942

FIS1
Mitochondrial fission 1 protein

1

0

Small-scale

0.249

Low

631944

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.249

Low

631977

HST2
NAD-dependent protein deacetylase HST2

1

0

High-throughput

0.249

Low

632005

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.249

Low

632007

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.249

Low

395224

GCN4
General control transcription factor GCN4

1

0

High-throughput

0.232

Low

475156

CISY2
Citrate synthase, peroxisomal

1

0

High-throughput

0.232

Low

506430

U5072
UPF0507 protein YML002W

1

0

High-throughput

0.232

Low

592001

VATB
V-type proton ATPase subunit B

1

0

High-throughput

0.232

Low

631860

MXR2
Peptide methionine sulfoxide reductase 2

1

0

High-throughput

0.232

Low

631862

PGPS1
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase

1

0

High-throughput

0.232

Low

631863

CTO1
Cold tolerance protein 1

1

0

High-throughput

0.232

Low

631873

TIM12
Mitochondrial import inner membrane translocase subunit TIM12

1

0

High-throughput

0.232

Low

631876

RGT1
Glucose transport transcription regulator RGT1

1

0

High-throughput

0.232

Low

631885

PAD1
Flavin prenyltransferase PAD1, mitochondrial

1

0

High-throughput

0.232

Low

631887

MED20
Mediator of RNA polymerase II transcription subunit 20

1

0

High-throughput

0.232

Low

631889

MDJ1
DnaJ homolog 1, mitochondrial

1

0

High-throughput

0.232

Low

631890

NU120
Nucleoporin NUP120

1

0

High-throughput

0.232

Low

631893

CBT1
Cytochrome b termination protein 1

1

0

High-throughput

0.232

Low

631894

PMU1
Probable phosphoglycerate mutase PMU1

1

0

High-throughput

0.232

Low

631895

YKH0
Uncharacterized protein YKL070W

1

0

High-throughput

0.232

Low

631896

PHD1
Putative transcription factor PHD1

1

0

High-throughput

0.232

Low

631897

TTI1
TEL2-interacting protein 1

1

0

High-throughput

0.232

Low

631901

YMC2
Carrier protein YMC2, mitochondrial

1

0

High-throughput

0.232

Low

631902

THI2
Thiamine biosynthesis regulatory protein

1

0

High-throughput

0.232

Low

631904

RTG3
Retrograde regulation protein 3

1

0

High-throughput

0.232

Low

631905

YBI1
Uncharacterized protein YBL081W

1

0

High-throughput

0.232

Low

631906

MOH1
Protein yippee-like MOH1

1

0

High-throughput

0.232

Low

631907

UMP1
Proteasome maturation factor UMP1

1

0

High-throughput

0.232

Low

631908

CS111
F-box protein COS111

1

0

High-throughput

0.232

Low

631909

TYDP1
Tyrosyl-DNA phosphodiesterase 1

1

0

High-throughput

0.232

Low

631910

YB75
Uncharacterized protein YBR225W

1

0

High-throughput

0.232

Low

631911

SHG1
COMPASS component SHG1

1

0

High-throughput

0.232

Low

631912

GRPE
GrpE protein homolog, mitochondrial

1

0

High-throughput

0.232

Low

631917

SHU1
Suppressor of HU sensitivity involved in recombination protein 1

1

0

High-throughput

0.232

Low

631918

RRF1
Ribosome-recycling factor, mitochondrial

1

0

High-throughput

0.232

Low

631921

YH10
Uncharacterized isomerase YHR210C

1

0

High-throughput

0.232

Low

631926

YM11
Uncharacterized protein YMR124W

1

0

High-throughput

0.232

Low

631933

SPC25
Kinetochore protein SPC25

1

0

High-throughput

0.232

Low

631934

JHD1
JmjC domain-containing histone demethylation protein 1

1

0

High-throughput

0.232

Low

631935

YEW7
Uncharacterized protein YEL137C

1

0

High-throughput

0.232

Low

631936

YE17
Uncharacterized protein YER187W

1

0

High-throughput

0.232

Low

631938

LDO45
Lipid droplet organization protein LDO45

1

0

High-throughput

0.232

Low

631939

PSF2
DNA replication complex GINS protein PSF2

1

0

High-throughput

0.232

Low

631940

UTP18
U3 small nucleolar RNA-associated protein 18

1

0

High-throughput

0.232

Low

631941

TAO3
Cell morphogenesis protein PAG1

1

0

High-throughput

0.232

Low

631943

MSL1
U2 small nuclear ribonucleoprotein B''

1

0

High-throughput

0.232

Low

631945

CBF3B
Centromere DNA-binding protein complex CBF3 subunit B

1

0

High-throughput

0.232

Low

631949

HAC1
Transcriptional activator HAC1

1

0

High-throughput

0.232

Low

631950

COQ7
5-demethoxyubiquinone hydroxylase, mitochondrial

1

0

High-throughput

0.232

Low

631951

PTE1
Peroxisomal acyl-coenzyme A thioester hydrolase 1

1

0

High-throughput

0.232

Low

631952

THI5
4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase THI5

1

0

High-throughput

0.232

Low

631958

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.232

Low

631959

ZAP1
Zinc-responsive transcriptional regulator ZAP1

1

0

High-throughput

0.232

Low

631960

TAD2
tRNA-specific adenosine deaminase subunit TAD2

1

0

High-throughput

0.232

Low

631961

MHO1
MEMO1 family protein MHO1

1

0

High-throughput

0.232

Low

631962

YJ11B
Transposon Ty1-JR1 Gag-Pol polyprotein

1

0

High-throughput

0.232

Low

631963

LIH1
Putative lipase LIH1

1

0

High-throughput

0.232

Low

631964

BPL1
Biotin--protein ligase

1

0

High-throughput

0.232

Low

631967

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

0

High-throughput

0.232

Low

631968

RPA14
DNA-directed RNA polymerase I subunit RPA14

1

0

High-throughput

0.232

Low

631969

LGUL
Glyoxalase I

1

0

High-throughput

0.232

Low

631970

ALAT1
Alanine aminotransferase, mitochondrial

1

0

High-throughput

0.232

Low

631971

STR3
Cystathionine beta-lyase

1

0

High-throughput

0.232

Low

631972

GID10
GID complex substrate-recognition subunit 10

1

0

High-throughput

0.232

Low

631973

ZPR1
Zinc finger chaperone ZPR1

1

0

High-throughput

0.232

Low

631975

COPZ
Coatomer subunit zeta

1

0

High-throughput

0.232

Low

631978

CSL4
Exosome complex component CSL4

1

0

High-throughput

0.232

Low

631979

YNT3
Uncharacterized protein YNL193W

1

0

High-throughput

0.232

Low

631986

CENPP
Inner kinetochore subunit CTF19

1

0

High-throughput

0.232

Low

631991

NSE5
Non-structural maintenance of chromosome element 5

1

0

High-throughput

0.232

Low

631992

PRP42
U1 small nuclear ribonucleoprotein component PRP42

1

0

High-throughput

0.232

Low

631993

YD132
Uncharacterized protein YDR132C

1

0

High-throughput

0.232

Low

631994

RT24
Small ribosomal subunit protein mS35

1

0

High-throughput

0.232

Low

631996

LCMT1
Leucine carboxyl methyltransferase 1

1

0

High-throughput

0.232

Low

631997

SDHF3
Succinate dehydrogenase assembly factor 3, mitochondrial

1

0

High-throughput

0.232

Low

631999

RM34
Large ribosomal subunit protein bL34m

1

0

High-throughput

0.232

Low

632000

YD124
Uncharacterized protein YDR124W

1

0

High-throughput

0.232

Low

632001

AIM32
Altered inheritance of mitochondria protein 32

1

0

High-throughput

0.232

Low

632002

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.232

Low

632006

IPK1
Inositol-pentakisphosphate 2-kinase

1

0

High-throughput

0.232

Low

632009

BDS1
Alkyl/aryl-sulfatase BDS1

1

0

High-throughput

0.232

Low

632010

SGO1
Shugoshin

1

0

High-throughput

0.232

Low

632012

RDR1
Protein RDR1

1

0

High-throughput

0.232

Low

632014

MTU1
Mitochondrial tRNA-specific 2-thiouridylase 1

1

0

High-throughput

0.232

Low

632015

BSC1
Bypass of stop codon protein 1

1

0

High-throughput

0.232

Low

632016

YG31A
Transposon Ty3-G Gag polyprotein

1

0

High-throughput

0.232

Low

632017

MSH5
MutS protein homolog 5

1

0

High-throughput

0.232

Low

632018

REC8
Meiotic recombination protein REC8

1

0

High-throughput

0.232

Low

632019

DAD1
DASH complex subunit DAD1

1

0

High-throughput

0.232

Low

632022

SFM1
Protein arginine N-methyltransferase SFM1

1

0

High-throughput

0.232

Low

632023

POM34
Nucleoporin POM34

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025