HitPredict

Interactor 1: DAB1 (P97318)
Disabled homolog 1
Gene: DAB1

Interactor 2: LRP1 (Q91ZX7)
Prolow-density lipoprotein receptor-related protein 1 (LRP-1) (Alpha-2-macroglobulin receptor) (A2MR) (CD antigen CD91) [Cleaved into: Low-density lipoprotein receptor-related protein 1 85 kDa subunit (LRP-85); Low-density lipoprotein receptor-related protein 1 515 kDa subunit (LRP-515); Low-density lipoprotein receptor-related protein 1 intracellular domain (LRPICD)]
Gene: LRP1

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.42	0.60	0.506

Property	Details
Experiments	10827173
Identification Methods	two hybrid, pull down
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0043025 - neuronal cell body GO:0045177 - apical part of cell
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 588 Mm			1 4545
+	Mm
		729617 DAB1_MOUSE (1-588): 2.98e-86: 281: 100.00		LDLR_MOUSE (4162-4517): 1.38e-12: 76.4: 10.90
+	Mm
		69879 DAB1_MOUSE (1-588): 2.98e-86: 281: 100.00		B1AXJ3_MOUSE (3256-3451): 4.34e-11: 71.8: 16.67
+	Mm
		956222 DAB1_MOUSE (1-588): 2.98e-86: 281: 100.00		VLDLR_MOUSE (4252-4499): 1.21e-10: 70.2: 13.41
+	Mm
		57553 DAB1_MOUSE (1-588): 2.98e-86: 281: 100.00		LRP2_MOUSE (4063-4378): 2.31e-10: 69.9: 11.54
+	Mm
		956234 DAB1_MOUSE (1-588): 2.98e-86: 281: 100.00		LRP8_MOUSE (24-285): 9.75e-10: 67.2: 19.33
+	Hs
		269145 DAB1_HUMAN (1-588): 1.81e-78: 260: 91.50		LRP8_HUMAN (4063-4405): 1.7e-12: 76.4: 13.26
+	Hs
		269134 DAB1_HUMAN (1-588): 1.81e-78: 260: 91.50		LRP2_HUMAN (27-263): 7.99e-11: 71.4: 19.03
+	Hs
		269133 DAB1_HUMAN (1-588): 1.81e-78: 260: 91.50		VLDLR_HUMAN (4245-4499): 1.29e-10: 70.2: 13.43
+	Hs
		269141 DAB1_HUMAN (1-588): 1.81e-78: 260: 91.50		LRP1_HUMAN (17-261): 9.34e-10: 67.9: 16.60
+	Hs
		269114 DAB1_HUMAN (1-588): 1.81e-78: 260: 91.50		LDLR_HUMAN (2450-2658): 4.92e-09: 64.9: 21.01
+	Hs
		992719 GULP1_HUMAN (17-327): 2.41e-59: 201: 19.69		LRP1_HUMAN (17-261): 9.34e-10: 67.9: 16.60
+	Mm
		966336 NUMB_MOUSE (4-549): 1.59e-53: 194: 15.90		NOTC1_MOUSE (1-219): 9.65e-12: 74.1: 13.10
+	Dm
		422741 DAB_DROME (2-583): 9.69e-46: 176: 17.93		NOTCH_DROME (2441-2876): 2.01e-15: 86.4: 11.47
+	Dm
		422717 NUMB_DROME (16-521): 7.19e-45: 169: 13.48		NOTCH_DROME (2441-2876): 2.01e-15: 86.4: 11.47
+	Hs
		957612 ARH_HUMAN (11-271): 2.37e-48: 172: 18.35		LRP2_HUMAN (27-263): 7.99e-11: 71.4: 19.03
+	Hs
		957621 ANS1B_HUMAN (8-229): 3.86e-44: 171: 16.81		LRP2_HUMAN (27-263): 7.99e-11: 71.4: 19.03
+	Hs
		992682 ANS1B_HUMAN (8-229): 3.86e-44: 171: 16.81		LRP1_HUMAN (17-261): 9.34e-10: 67.9: 16.60
+	Hs
		351073 ARH_HUMAN (11-271): 2.37e-48: 172: 18.35		LDLR_HUMAN (2450-2658): 4.92e-09: 64.9: 21.01
+	Mm
		57558 ARH_MOUSE (8-271): 6.79e-45: 163: 16.67		LRP2_MOUSE (4063-4378): 2.31e-10: 69.9: 11.54
+	Rn
		292326 DAB2_RAT (8-587): 1.04e-40: 159: 25.34		LRP2_RAT (4063-4378): 1.75e-10: 70.2: 12.57