HitPredict

Interactor 1: EYA3 (P97480)
Eyes absent homolog 3 (EC 3.1.3.48)
Gene: EYA3

Interactor 2: SIX1 (Q62231)
Homeobox protein SIX1 (Sine oculis homeobox homolog 1)
Gene: SIX1

Species: Mus musculus

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	20211142
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Hydrolase~SIX1_SD
Common GO terms	GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005667 - transcription regulator complex GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 510 Mm			1 284
+	Hs
		118562 EYA2_HUMAN (44-510): 0: 690: 48.21		SIX1_HUMAN (1-284): 3.68e-90: 271: 99.30
+	Hs
		1304309 EYA3_HUMAN (1-510): 0: 708: 86.72		SIX2_HUMAN (1-284): 1.37e-80: 246: 72.97
+	Hs
		318622 EYA4_HUMAN (9-510): 0: 683: 51.36		SIX1_HUMAN (1-284): 3.68e-90: 271: 99.30
+	Hs
		92587 E9PLN6_HUMAN (4-510): 0: 677: 51.44		SIX1_HUMAN (1-284): 3.68e-90: 271: 99.30
+	Hs
		1074456 EYA1_HUMAN (11-510): 0: 672: 49.55		SIX1_HUMAN (1-284): 3.68e-90: 271: 99.30
+	Mm
		936192 EYA3_MOUSE (1-510): 0: 752: 100.00		SIX5_MOUSE (1-275): 1.56e-54: 189: 43.11
+	Hs
		118611 EYA2_HUMAN (44-510): 0: 690: 48.21		SIX2_HUMAN (1-284): 1.37e-80: 246: 72.97
+	Mm
		956885 EYA1_MOUSE (11-510): 0: 665: 48.92		SIX1_MOUSE (1-284): 2.42e-89: 269: 100.00
+	Hs
		318733 EYA4_HUMAN (9-510): 0: 683: 51.36		SIX2_HUMAN (1-284): 1.37e-80: 246: 72.97
+	Hs
		92588 E9PLN6_HUMAN (4-510): 0: 677: 51.44		SIX2_HUMAN (1-284): 1.37e-80: 246: 72.97
+	Hs
		118619 EYA2_HUMAN (44-510): 0: 690: 48.21		SIX4_HUMAN (6-275): 8.75e-69: 229: 51.11
+	Hs
		1304296 EYA1_HUMAN (11-510): 0: 672: 49.55		SIX2_HUMAN (1-284): 1.37e-80: 246: 72.97
+	Hs
		318748 EYA4_HUMAN (9-510): 0: 683: 51.36		SIX4_HUMAN (6-275): 8.75e-69: 229: 51.11
+	Hs
		1304297 EYA1_HUMAN (11-510): 0: 672: 49.55		SIX4_HUMAN (6-275): 8.75e-69: 229: 51.11
+	Mm
		139225 EYA2_MOUSE (17-510): 0: 668: 46.13		SIX4_MOUSE (5-273): 9.59e-69: 228: 50.56
+	Mm
		956884 EYA1_MOUSE (11-510): 0: 665: 48.92		SIX4_MOUSE (5-273): 9.59e-69: 228: 50.56
+	Hs
		1230645 EYA3_HUMAN (1-510): 0: 708: 86.72		SIX5_HUMAN (7-252): 1.24e-52: 184: 45.17
+	Hs
		318670 EYA4_HUMAN (9-510): 0: 683: 51.36		SIX5_HUMAN (7-252): 1.24e-52: 184: 45.17
+	Hs
		1230644 EYA1_HUMAN (11-510): 0: 672: 49.55		SIX5_HUMAN (7-252): 1.24e-52: 184: 45.17
+	Mm
		936193 EYA1_MOUSE (11-510): 0: 665: 48.92		SIX5_MOUSE (1-275): 1.56e-54: 189: 43.11