HitPredict

Interactor 1: SHC1 (P98083)
SHC-transforming protein 1 (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
Gene: SHC1

Interactor 2: GRB2 (Q60631)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 1.00 0.986

The method score is based on:

Property Details
Experiments 10995764, 10362356, 7689150, 8479540, 9013573, 20697350, 7538132, 8524223, 8294403, 11707404, 9252386, 7717978, 18174162, 17314098, 23452850, 11259577, 10748054, 17673906, 18273058, 7529871 and 1 others

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Identification Methods far western blotting, pull down, affinity chromatography technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, coimmunoprecipitation
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains SH2~SH2, SH2~SH3_1
Common GO terms GO:0001784 - phosphotyrosine residue binding
GO:0005068 - transmembrane receptor protein tyrosine kinase adaptor activity
GO:0005154 - epidermal growth factor receptor binding
GO:0005168 - neurotrophin TRKA receptor binding
GO:0005829 - cytosol
and 8 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 579
Mm

1 217
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Last updated: 15 Jul 2024