Protein: FBXL2
F-box/LRR-repeat protein 2 (F-box and leucine-rich repeat protein 2) (F-box protein FBL2/FBL3)

Gene: FBXL2
Organism: Homo sapiens
Interactions: 37
UniProt ID: Q9UKC9

Gene Ontology (top 5):
GO:0005516 - calmodulin binding
GO:0005737 - cytoplasm
GO:0006508 - proteolysis
GO:0006513 - protein monoubiquitination
GO:0010506 - regulation of autophagy

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

992385

SKP1
S-phase kinase-associated protein 1

15

20

Small-scale

0.983

High

1112782

CUL1
Cullin-1

7

20

Small-scale

0.956

High

1460971

FBX3
F-box only protein 3

3

1

Small-scale

0.827

High

1399405

NLRP3
NACHT, LRR and PYD domains-containing protein 3

2

16

Small-scale

0.825

High

1391841

AURKB
Aurora kinase B

2

9

Small-scale

0.746

High

1128500

ITPR3
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3

3

1

Small-scale

0.664

High

1113018

CUL2
Cullin-2

1

20

Small-scale

0.618

High

883360

UB2R1
Ubiquitin-conjugating enzyme E2 R1

2

8

Small-scale

0.602

High

957235

UB2D3
Ubiquitin-conjugating enzyme E2 D3

2

4

Small-scale

0.602

High

1061625

FOXM1
Forkhead box protein M1

3

2

Small-scale

0.599

High

253725

YPEL1
Protein yippee-like 1

2

3

High-throughput

0.574

High

959546

YPEL3
Protein yippee-like 3

2

3

High-throughput

0.574

High

468900

HS90B
Heat shock protein HSP 90-beta

2

17

High-throughput

0.571

High

136444

P85B
Phosphatidylinositol 3-kinase regulatory subunit beta

1

8

Small-scale

0.561

High

364004

EGFR
Epidermal growth factor receptor

1

20

Small-scale

0.561

High

423430

A4
Amyloid-beta precursor protein

1

3

Small-scale

0.561

High

718852

CCND2
G1/S-specific cyclin-D2

1

10

Small-scale

0.561

High

533053

CH60
60 kDa heat shock protein, mitochondrial

1

3

High-throughput

0.515

High

906821

UB2D1
Ubiquitin-conjugating enzyme E2 D1

1

4

Small-scale

0.501

High

984019

RBX1
E3 ubiquitin-protein ligase RBX1

1

11

Small-scale

0.501

High

231411

PDE6D
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta

1

1

Small-scale

0.479

High

462029

HS90A
Heat shock protein HSP 90-alpha

1

15

High-throughput

0.479

High

699886

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

1

Small-scale

0.479

High

911153

IMA1
Importin subunit alpha-1

1

5

High-throughput

0.479

High

921580

PGTB2
Geranylgeranyl transferase type-2 subunit beta

1

1

Small-scale

0.479

High

935271

TERA
Transitional endoplasmic reticulum ATPase

1

3

Small-scale

0.479

High

1033956

SC6A3
Sodium-dependent dopamine transporter

1

3

Small-scale

0.479

High

1090200

PTN13
Tyrosine-protein phosphatase non-receptor type 13

1

1

Small-scale

0.479

High

1439003

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

11

Small-scale

0.479

High

876220

TCPE
T-complex protein 1 subunit epsilon

1

2

High-throughput

0.470

High

970231

UB2G1
Ubiquitin-conjugating enzyme E2 G1

1

6

Small-scale

0.457

High

786919

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

12

Small-scale

0.457

High

1453722

HACD3
Very-long-chain

1

3

Small-scale

0.437

High

1461032

SGT1
Protein SGT1 homolog

1

19

High-throughput

0.407

High

378582

IL1B
Interleukin-1 beta

1

0

Small-scale

0.261

Low

1309037

FUND1
FUN14 domain-containing protein 1

1

0

Small-scale

0.249

Low

1036629

CO7A1
Collagen alpha-1(VII) chain

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025