HitPredict

Interactor 1: SHC1 (P98083)
SHC-transforming protein 1 (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
Gene: SHC1

Interactor 2: GAB2 (Q9Z1S8)
GRB2-associated-binding protein 2 (GRB2-associated binder 2) (Growth factor receptor bound protein 2-associated protein 2) (PH domain-containing adaptor molecule p97)
Gene: GAB2

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	20697350
Identification Methods	pull down
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005068 - transmembrane receptor protein tyrosine kinase adaptor activity GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0008284 - positive regulation of cell population proliferation GO:0035556 - intracellular signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 579 Mm			1 665
+	Mm
		957233 SHC1_MOUSE (1-579): 0: 536: 100.00		Q3ZB59_MOUSE (1-665): 6.22e-180: 528: 99.85
+	Hs
		666193 SHC1_HUMAN (1-579): 5.04e-179: 520: 94.17		GAB2_HUMAN (4-665): 1.34e-176: 520: 90.67
+	Mm
		957247 SHC1_MOUSE (1-579): 0: 536: 100.00		GAB1_MOUSE (5-664): 7.18e-125: 387: 36.23
+	Hs
		666100 SHC1_HUMAN (1-579): 5.04e-179: 520: 94.17		GAB1_HUMAN (5-664): 3.8e-125: 388: 35.71
+	Hs
		1035394 SHC3_HUMAN (6-578): 1.07e-127: 389: 44.83		GAB1_HUMAN (5-664): 3.8e-125: 388: 35.71
+	Hs
		523213 SRC_HUMAN (334-570): 7.45e-44: 166: 16.87		GAB2_HUMAN (4-665): 1.34e-176: 520: 90.67
+	Hs
		557834 NCK1_HUMAN (360-571): 3.06e-42: 157: 19.37		GAB2_HUMAN (4-665): 1.34e-176: 520: 90.67
+	Hs
		1035381 TENS3_HUMAN (6-569): 1.24e-80: 278: 15.07		GAB1_HUMAN (5-664): 3.8e-125: 388: 35.71
+	Hs
		275569 BCAR3_HUMAN (349-579): 5.99e-47: 178: 20.70		GAB1_HUMAN (5-664): 3.8e-125: 388: 35.71
+	Hs
		522965 SRC_HUMAN (334-570): 7.45e-44: 166: 16.87		GAB1_HUMAN (5-664): 3.8e-125: 388: 35.71
+	Mm
		403466 SRC_MOUSE (334-570): 3.59e-44: 166: 16.87		GAB1_MOUSE (5-664): 7.18e-125: 387: 36.23
+	Hs
		426958 FES_HUMAN (366-577): 4.45e-41: 161: 24.30		GAB1_HUMAN (5-664): 3.8e-125: 388: 35.71
+	Hs
		557681 NCK1_HUMAN (360-571): 3.06e-42: 157: 19.37		GAB1_HUMAN (5-664): 3.8e-125: 388: 35.71
+	Hs
		846468 BLK_HUMAN (362-577): 2.17e-40: 155: 18.14		GAB1_HUMAN (5-664): 3.8e-125: 388: 35.71
+	Hs
		523086 SRC_HUMAN (334-570): 7.45e-44: 166: 16.87		GAB3_HUMAN (1-656): 5.85e-93: 301: 31.55
+	Hs
		412280 FYN_HUMAN (367-579): 2.26e-40: 156: 18.86		GAB3_HUMAN (1-656): 5.85e-93: 301: 31.55
+	Dm
		1358412 Q9V3C8_DROME (128-577): 3.33e-84: 270: 37.33		DOS_DROME (7-620): 1.69e-43: 169: 17.92
+	Hs
		203208 NCK1_HUMAN (360-571): 3.06e-42: 157: 19.37		SYNJ1_HUMAN (123-640): 1.41e-53: 201: 14.86
+	Hs
		1153427 GULP1_HUMAN (139-441): 3.41e-45: 163: 16.72		PKHA7_HUMAN (1-549): 2.93e-39: 157: 13.53
+	Hs
		1268502 ANS1A_HUMAN (40-400): 6.82e-46: 176: 17.34		DEFI6_HUMAN (8-114): 6.87e-15: 80.1: 25.23