HitPredict

Interactor 1: IDD (P98153)
Integral membrane protein DGCR2/IDD
Gene: DGCR2

Interactor 2: SMUF2 (Q9HAU4)
E3 ubiquitin-protein ligase SMURF2 (hSMURF2) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF2) (SMAD ubiquitination regulatory factor 2) (SMAD-specific E3 ubiquitin-protein ligase 2)
Gene: SMURF2

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.43	0.50	0.464

Property	Details
Experiments	15231748
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 550 Hs			1 748
+	Hs
		808089 IDD_HUMAN (1-550): 4.55e-155: 456: 100.00		NEDD4_HUMAN (104-746): 0: 628: 38.73
+	Mm
		57546 LRAD3_MOUSE (29-115): 5.21e-10: 63.1: 30.00		ITCH_MOUSE (3-748): 0: 659: 32.95
+	Hs
		808178 LRAD3_HUMAN (29-115): 5.91e-10: 63.1: 30.00		NEDD4_HUMAN (104-746): 0: 628: 38.73
+	Hs
		957463 IDD_HUMAN (1-550): 4.55e-155: 456: 100.00		NED4L_HUMAN (5-396): 1.96e-36: 149: 18.58
+	Hs
		125376 IDD_HUMAN (1-550): 4.55e-155: 456: 100.00		WWP2_HUMAN (1-416): 7.64e-26: 116: 17.39
+	Hs
		957474 IDD_HUMAN (1-550): 4.55e-155: 456: 100.00		WWP1_HUMAN (2-395): 4.38e-20: 97.5: 15.47
+	Hs
		957497 IDD_HUMAN (1-550): 4.55e-155: 456: 100.00		HECW2_HUMAN (19-281): 8.01e-17: 87.5: 14.80
+	Hs
		270320 LRP6_HUMAN (178-357): 9.85e-13: 73.4: 9.47		ITCH_HUMAN (1-426): 2.45e-23: 107: 16.44
+	Hs
		1205571 LRAD3_HUMAN (29-115): 5.91e-10: 63.1: 30.00		ITCH_HUMAN (1-426): 2.45e-23: 107: 16.44
+	Hs
		1205572 LRAD3_HUMAN (29-115): 5.91e-10: 63.1: 30.00		WWP1_HUMAN (2-395): 4.38e-20: 97.5: 15.47