HitPredict

Interactor 1: CDK3 (Q00526)
Cyclin-dependent kinase 3 (EC 2.7.11.22) (Cell division protein kinase 3)
Gene: CDK3

Interactor 2: SKP2 (Q13309)
S-phase kinase-associated protein 2 (Cyclin-A/CDK2-associated protein p45) (F-box protein Skp2) (F-box/LRR-repeat protein 1) (p45skp2)
Gene: SKP2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.81	0.60	0.699

Property	Details
Experiments	26186194, 28514442, 33961781, 23602568
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000082 - G1/S transition of mitotic cell cycle GO:0005634 - nucleus
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 305 Hs			1 424
+	Hs
		625407 CDK2_HUMAN (1-292): 1.87e-148: 420: 76.71		SKP2_HUMAN (1-424): 3e-94: 291: 100.00
+	Hs
		414902 CDK1_HUMAN (1-290): 1.16e-137: 392: 65.98		SKP2_HUMAN (1-424): 3e-94: 291: 100.00
+	Hs
		960280 CDK5_HUMAN (1-292): 8.97e-133: 380: 60.75		SKP2_HUMAN (1-424): 3e-94: 291: 100.00
+	Dm
		618398 CDK1_DROME (1-288): 2.07e-133: 381: 65.40		Q7YZ95_DROME (75-405): 5.44e-45: 166: 32.54
+	Dm
		618452 CDK2_DROME (1-301): 6.29e-129: 371: 60.47		Q7YZ95_DROME (75-405): 5.44e-45: 166: 32.54
+	At
		1106652 MPK6_ARATH (9-304): 2.73e-127: 370: 37.05		IMK2_ARATH (136-381): 6.63e-37: 145: 16.13