Interactor 1: HSF1 (Q00613)
Heat shock factor protein 1 (HSF 1) (Heat shock transcription factor 1) (HSTF 1)
Gene: HSF1

Interactor 2: HSF4 (Q9ULV5)
Heat shock factor protein 4 (HSF 4) (hHSF4) (Heat shock transcription factor 4) (HSTF 4)
Gene: HSF4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.65 1.00 0.811

The method score is based on:

Property Details
Experiments 33961781, 25036637
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains HSF_DNA-bind~HSF_DNA-bind
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0003700 - DNA-binding transcription factor activity
and 3 others

more...

Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 529
Hs

1 492
+ Hs
+ Hs
+ Hs
+ Dm
+ Tt
+ At
+ At
+ At
+ At
+ Ce
+ At
+ At
+ Hs
+ At
+ Sc
+ Os
+ Sc

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Last updated: 15 Jul 2024