Protein: RL27A
Large ribosomal subunit protein eL27A (60S ribosomal protein L27-A)

Gene: RL27A, RPL27A
Organism: Saccharomyces cerevisiae S288C
Interactions: 169
UniProt ID: P0C2H6

Gene Ontology (top 5):
GO:0002181 - cytoplasmic translation
GO:0003735 - structural constituent of ribosome
GO:0005829 - cytosol
GO:0022625 - cytosolic large ribosomal subunit

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

433365

RL26A
Large ribosomal subunit protein uL24A

2

2

High-throughput

0.754

High

503747

RL8A
Large ribosomal subunit protein eL8A

2

4

High-throughput

0.754

High

503762

RL8B
Large ribosomal subunit protein eL8B

2

4

High-throughput

0.754

High

503759

RL16A
Large ribosomal subunit protein uL13A

3

2

High-throughput

0.640

High

503744

RL30
Large ribosomal subunit protein eL30

1

2

High-throughput

0.618

High

503778

RL14A
Large ribosomal subunit protein eL14A

1

2

High-throughput

0.618

High

503781

GBLP
Small ribosomal subunit protein RACK1

1

3

High-throughput

0.618

High

503785

RL14B
Large ribosomal subunit protein eL14B

1

2

High-throughput

0.618

High

503801

RL34B
Large ribosomal subunit protein eL34B

1

4

High-throughput

0.618

High

503817

RL26B
Large ribosomal subunit protein uL24B

1

2

High-throughput

0.618

High

503832

RL34A
Large ribosomal subunit protein eL34A

1

4

High-throughput

0.618

High

503779

RPF2
Ribosome biogenesis protein RPF2

3

1

High-throughput

0.593

High

503809

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.586

High

503742

CAF20
Cap-associated protein CAF20

3

1

Small-scale

0.585

High

503733

RL2A
Large ribosomal subunit protein uL2A

2

2

High-throughput

0.584

High

503734

RL18B
Large ribosomal subunit protein eL18B

2

1

High-throughput

0.584

High

503764

ZUO1
Zuotin

2

2

High-throughput

0.584

High

503816

LSG1
Large subunit GTPase 1

2

3

High-throughput

0.584

High

503752

SIS1
Protein SIS1

2

0

High-throughput

0.576

High

392060

HSP82
ATP-dependent molecular chaperone HSP82

2

0

High-throughput

0.559

High

503787

SSZ1
Ribosome-associated complex subunit SSZ1

2

0

High-throughput

0.559

High

503822

BRE5
UBP3-associated protein BRE5

1

4

High-throughput

0.536

High

503834

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

1

High-throughput

0.536

High

503828

NOP15
Ribosome biogenesis protein 15

2

1

High-throughput

0.533

High

503862

NOP53
Ribosome biogenesis protein NOP53

2

1

Small-scale

0.521

High

503755

PWP2
Periodic tryptophan protein 2

1

0

High-throughput

0.517

High

154112

RL36B
Large ribosomal subunit protein eL36B

1

2

High-throughput

0.479

High

383055

RLA4
Large ribosomal subunit protein P2B

1

2

High-throughput

0.479

High

409857

RL25
Large ribosomal subunit protein uL23

1

1

High-throughput

0.479

High

432445

RL7A
Large ribosomal subunit protein uL30A

1

3

High-throughput

0.479

High

432951

RL6B
Large ribosomal subunit protein eL6B

1

2

High-throughput

0.479

High

434484

RL22A
Large ribosomal subunit protein eL22A

1

2

High-throughput

0.479

High

436269

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

4

High-throughput

0.479

High

481934

C1TM
C-1-tetrahydrofolate synthase, mitochondrial

1

1

High-throughput

0.479

High

503724

RL27A
Large ribosomal subunit protein eL27A

1

4

High-throughput

0.479

High

503725

RL27B
Large ribosomal subunit protein eL27B

1

4

High-throughput

0.479

High

503729

RL20B
Large ribosomal subunit protein eL20B

1

1

High-throughput

0.479

High

503730

RL43B
Large ribosomal subunit protein eL43B

1

2

High-throughput

0.479

High

503731

RS6A
Small ribosomal subunit protein eS6A

1

1

High-throughput

0.479

High

503735

RL12B
Large ribosomal subunit protein uL11B

1

1

High-throughput

0.479

High

503737

RL19B
Large ribosomal subunit protein eL19

1

2

High-throughput

0.479

High

503738

RL35A
Large ribosomal subunit protein uL29A

1

2

High-throughput

0.479

High

503739

HSP71
Heat shock protein SSA1

1

2

High-throughput

0.479

High

503740

RLA3
Large ribosomal subunit protein P1B

1

2

High-throughput

0.479

High

503745

RL3
Large ribosomal subunit protein uL3

1

1

High-throughput

0.479

High

503758

RL5
Large ribosomal subunit protein uL18

1

2

High-throughput

0.479

High

503763

EF2
Elongation factor 2

1

2

Small-scale

0.479

High

503772

RS3A1
Small ribosomal subunit protein eS1A

1

1

High-throughput

0.479

High

503782

ATG8
Autophagy-related protein 8

1

3

High-throughput

0.479

High

503790

NMD3
60S ribosomal export protein NMD3

1

1

High-throughput

0.479

High

503795

IF2P
Eukaryotic translation initiation factor 5B

1

1

High-throughput

0.479

High

503799

RL13B
Large ribosomal subunit protein eL13B

1

1

High-throughput

0.479

High

503804

RLP7
Ribosome biogenesis protein RLP7

1

3

High-throughput

0.479

High

503806

RL10
Large ribosomal subunit protein uL16

1

2

High-throughput

0.479

High

503811

RL37A
Large ribosomal subunit protein eL37A

1

2

High-throughput

0.479

High

503812

RL4B
Large ribosomal subunit protein uL4B

1

2

High-throughput

0.479

High

503813

RL37B
Large ribosomal subunit protein eL37B

1

2

High-throughput

0.479

High

503831

RL22B
Large ribosomal subunit protein eL22B

1

2

High-throughput

0.479

High

503837

RL6A
Large ribosomal subunit protein eL6A

1

2

High-throughput

0.479

High

503838

RL21A
Large ribosomal subunit protein eL21A

1

2

High-throughput

0.479

High

503853

NOC4
Nucleolar complex protein 4

1

1

High-throughput

0.479

High

503858

RS10A
Small ribosomal subunit protein eS10A

1

1

High-throughput

0.479

High

503861

TMA46
Translation machinery-associated protein 46

1

1

High-throughput

0.479

High

503868

RL21B
Large ribosomal subunit protein eL21B

1

2

High-throughput

0.479

High

503869

RL13A
Large ribosomal subunit protein eL13A

1

1

High-throughput

0.479

High

503872

RL11B
Large ribosomal subunit protein uL5B

1

2

High-throughput

0.479

High

149507

RS9A
Small ribosomal subunit protein uS4A

1

0

High-throughput

0.458

High

383438

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.458

High

434718

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

435690

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.458

High

441626

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.458

High

454790

RS19A
Small ribosomal subunit protein eS19A

1

0

High-throughput

0.458

High

502767

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.458

High

503726

RL31A
Large ribosomal subunit protein eL31A

1

0

High-throughput

0.458

High

503732

RS8A
Small ribosomal subunit protein eS8A

1

0

High-throughput

0.458

High

503736

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.458

High

503753

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.458

High

503760

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.458

High

503767

RSSA1
Small ribosomal subunit protein uS2A

1

0

High-throughput

0.458

High

503768

SMY2
Protein SMY2

1

0

High-throughput

0.458

High

503776

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.458

High

503783

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.458

High

503791

RIX1
Pre-rRNA-processing protein RIX1

1

0

Small-scale

0.458

High

503794

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.458

High

503815

DXO
Decapping nuclease RAI1

1

0

Small-scale

0.458

High

503836

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.458

High

503846

VMS1
tRNA endonuclease VMS1

1

0

High-throughput

0.458

High

503848

LTN1
E3 ubiquitin-protein ligase listerin

1

0

Small-scale

0.458

High

503727

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

4

High-throughput

0.445

High

503798

SSB2
Ribosome-associated molecular chaperone SSB2

1

2

High-throughput

0.445

High

438570

SC160
Protein SCP160

1

2

High-throughput

0.437

High

503728

HSP77
Import motor subunit, mitochondrial

1

2

High-throughput

0.437

High

503751

KCC2
Calcium/calmodulin-dependent protein kinase II

1

1

High-throughput

0.437

High

503757

SPB4
ATP-dependent rRNA helicase SPB4

1

2

High-throughput

0.437

High

503765

PP12
Serine/threonine-protein phosphatase PP1-2

1

1

Small-scale

0.437

High

503769

MRT4
Ribosome assembly factor MRT4

1

1

Small-scale

0.437

High

503771

IXR1
Intrastrand cross-link recognition protein

1

4

Small-scale

0.437

High

503775

RRP1
Ribosomal RNA-processing protein 1

1

1

Small-scale

0.437

High

503784

ECM29
Proteasome component ECM29

1

3

High-throughput

0.437

High

503793

STM1
Suppressor protein STM1

1

1

Small-scale

0.437

High

503797

NUG1
Nuclear GTP-binding protein NUG1

1

3

High-throughput

0.437

High

503800

TM108
Protein TMA108

1

1

High-throughput

0.437

High

503803

DSN1
Kinetochore-associated protein DSN1

1

1

High-throughput

0.437

High

503807

MOG1
Nuclear import protein MOG1

1

1

High-throughput

0.437

High

503808

HGH1
Protein HGH1

1

1

Small-scale

0.437

High

503820

YG3A
Uncharacterized protein YGR130C

1

5

Small-scale

0.437

High

503821

SDA1
Protein SDA1

1

1

High-throughput

0.437

High

503823

NOG2
Nucleolar GTP-binding protein 2

1

3

Small-scale

0.437

High

503824

GIS2
Zinc finger protein GIS2

1

3

High-throughput

0.437

High

503825

NOP13
Nucleolar protein 13

1

1

High-throughput

0.437

High

503833

NUM1
Nuclear migration protein NUM1

1

1

High-throughput

0.437

High

503840

NOG1
Nucleolar GTP-binding protein 1

1

1

High-throughput

0.437

High

503841

TOM1
E3 ubiquitin-protein ligase TOM1

1

2

High-throughput

0.437

High

503842

ARX1
Probable metalloprotease ARX1

1

3

High-throughput

0.437

High

503843

RRP17
Ribosomal RNA-processing protein 17

1

1

High-throughput

0.437

High

503844

DHR1
Probable ATP-dependent RNA helicase DHR1

1

1

High-throughput

0.437

High

503845

SEG1
Eisosome protein SEG1

1

1

Small-scale

0.437

High

503847

PUF6
Pumilio homology domain family member 6

1

1

High-throughput

0.437

High

503850

EIS1
Eisosome protein 1

1

1

Small-scale

0.437

High

503852

RRP45
Exosome complex component RRP45

1

1

High-throughput

0.437

High

503854

VAM6
Vacuolar morphogenesis protein 6

1

1

High-throughput

0.437

High

503856

BRX1
Ribosome biogenesis protein BRX1

1

4

High-throughput

0.437

High

503859

AP3D
AP-3 complex subunit delta

1

1

High-throughput

0.437

High

503863

RRP6
Exosome complex exonuclease RRP6

1

1

High-throughput

0.437

High

503864

MAK21
Ribosome biogenesis protein MAK21

1

1

High-throughput

0.437

High

503865

RRP42
Exosome complex component RRP42

1

1

High-throughput

0.437

High

503866

DBP10
ATP-dependent RNA helicase DBP10

1

3

High-throughput

0.437

High

503867

RQC2
Ribosome quality control complex subunit 2

1

1

High-throughput

0.437

High

503786

CIC1
Proteasome-interacting protein CIC1

2

0

High-throughput

0.305

High

503805

NOP2
25S rRNA

2

0

Small-scale

0.305

High

503819

PESC
Pescadillo homolog

2

0

High-throughput

0.305

High

503802

ULP2
Ubiquitin-like-specific protease 2

1

0

High-throughput

0.251

Low

366750

IPYR
Inorganic pyrophosphatase

1

0

High-throughput

0.249

Low

503741

HMDH1
3-hydroxy-3-methylglutaryl-coenzyme A reductase 1

1

0

High-throughput

0.249

Low

503743

RPOM
DNA-directed RNA polymerase, mitochondrial

1

0

High-throughput

0.249

Low

503746

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

0

High-throughput

0.249

Low

503748

SKI3
Superkiller protein 3

1

0

High-throughput

0.249

Low

503749

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

0

High-throughput

0.249

Low

503750

ODO1
2-oxoglutarate dehydrogenase, mitochondrial

1

0

High-throughput

0.249

Low

503754

KRR1
KRR1 small subunit processome component

1

0

High-throughput

0.249

Low

503756

PAT1
Deadenylation-dependent mRNA-decapping factor PAT1

1

0

Small-scale

0.249

Low

503761

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.249

Low

503766

FIMB
Fimbrin

1

0

Small-scale

0.249

Low

503770

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

1

0

High-throughput

0.249

Low

503773

SKT5
Chitin synthase regulator SKT5

1

0

High-throughput

0.249

Low

503774

URB1
Nucleolar pre-ribosomal-associated protein 1

1

0

Small-scale

0.249

Low

503777

EAP1
Protein EAP1

1

0

High-throughput

0.249

Low

503780

NOP4
Nucleolar protein 4

1

0

High-throughput

0.249

Low

503788

SSF1
Ribosome biogenesis protein SSF1

1

0

Small-scale

0.249

Low

503792

ATU2
Copper-transporting ATPase

1

0

High-throughput

0.249

Low

503796

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

0

High-throughput

0.249

Low

503810

VATG
V-type proton ATPase subunit G

1

0

High-throughput

0.249

Low

503814

YOR1
Oligomycin resistance ATP-dependent permease YOR1

1

0

High-throughput

0.249

Low

503818

EIF2A
Eukaryotic translation initiation factor 2A

1

0

High-throughput

0.249

Low

503826

NAT10
RNA cytidine acetyltransferase

1

0

High-throughput

0.249

Low

503827

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

1

0

Small-scale

0.249

Low

503829

NST1
Stress response protein NST1

1

0

High-throughput

0.249

Low

503830

ORC1
Origin recognition complex subunit 1

1

0

High-throughput

0.249

Low

503835

SPR6
Sporulation-specific protein

1

0

High-throughput

0.249

Low

503839

XRN2
5'-3' exoribonuclease 2

1

0

High-throughput

0.249

Low

503849

RRP5
rRNA biogenesis protein RRP5

1

0

High-throughput

0.249

Low

503851

RQC1
Ribosome quality control complex subunit 1

1

0

Small-scale

0.249

Low

503855

BUD20
Bud site selection protein 20

1

0

High-throughput

0.249

Low

503857

SGO1
Shugoshin

1

0

High-throughput

0.249

Low

503860

NIP7
60S ribosome subunit biogenesis protein NIP7

1

0

High-throughput

0.249

Low

503870

RRP12
Ribosomal RNA-processing protein 12

1

0

High-throughput

0.249

Low

503871

EFG1P
rRNA-processing protein EFG1

1

0

Small-scale

0.249

Low

503789

RPF1
Ribosome production factor 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025