HitPredict

Interactor 1: FAK1 (Q00944)
Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Focal adhesion kinase-related nonkinase) (FRNK) (p41/p43FRNK) (Protein-tyrosine kinase 2) (p125FAK) (pp125FAK)
Gene: PTK2

Interactor 2: FAK1 (Q00944)
Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Focal adhesion kinase-related nonkinase) (FRNK) (p41/p43FRNK) (Protein-tyrosine kinase 2) (p125FAK) (pp125FAK)
Gene: PTK2

Species: Gallus gallus

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.66 1.00 0.812

The method score is based on:

Property Details
Experiments 20802513, 9425168
Identification Methods anti tag coimmunoprecipitation, protein kinase assay
Interaction Type physical association, phosphorylation reaction, putative self interaction

The annotation score is based on:

Property Details
Interacting Pfam domains FERM_M~FERM_M, FERM_M~FERM_N_2, FERM_M~PK_Tyr_Ser-Thr, FERM_N_2~PK_Tyr_Ser-Thr, Focal_AT~Focal_AT, PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr
Common GO terms GO:0002020 - protease binding
GO:0004198 - calcium-dependent cysteine-type endopeptidase activity
GO:0004713 - protein tyrosine kinase activity
GO:0004715 - non-membrane spanning protein tyrosine kinase activity
GO:0005178 - integrin binding
and 30 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 1053
Gg

1 1053
+ Hs
+ Mm
+ Rn
+ Rn
+ Gg
+ Hs
+ Hs
+ Hs
+ Mm
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs
+ Mm
+ Rn
+ Mm
+ Hs
+ Hs
+ Mm

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024