HitPredict

Interactor 1: MDM2 (Q00987)
E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Hdm2) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2)
Gene: MDM2

Interactor 2: ITCH (Q96J02)
E3 ubiquitin-protein ligase Itchy homolog (Itch) (EC 2.3.2.26) (Atrophin-1-interacting protein 4) (AIP4) (HECT-type E3 ubiquitin transferase Itchy homolog) (NFE2-associated polypeptide 1) (NAPP1)
Gene: ITCH

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

The method score is based on:

Property	Details
Experiments	26025930, 21093410
Identification Methods	affinity chromatography technology
Interaction Type	physical association

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0004842 - ubiquitin-protein transferase activity GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane and 10 others more... GO:0006511 - ubiquitin-dependent protein catabolic process GO:0006915 - apoptotic process GO:0016567 - protein ubiquitination GO:0016874 - ligase activity GO:0032991 - protein-containing complex GO:0043021 - ribonucleoprotein complex binding GO:0043066 - negative regulation of apoptotic process GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process GO:0051865 - protein autoubiquitination GO:0061630 - ubiquitin protein ligase activity
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1	491
Hs

1	903

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024