HitPredict

Interactor 1: MDM2 (Q00987)
E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Hdm2) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2)
Gene: MDM2

Interactor 2: RASF1 (Q9NS23)
Ras association domain-containing protein 1
Gene: RASSF1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.621

Property	Details
Experiments	23038753, 18566590
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0008270 - zinc ion binding GO:0051726 - regulation of cell cycle
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 491 Hs			1 344
+	Mm
		620858 MDM2_MOUSE (1-490): 0: 639: 80.24		RASF1_MOUSE (1-344): 1.17e-146: 418: 89.83
+	Hs
		962886 MDM2_HUMAN (1-491): 0: 710: 100.00		RASF5_HUMAN (11-339): 8.08e-111: 330: 43.23
+	Mm
		620841 MDM2_MOUSE (1-490): 0: 639: 80.24		RASF5_MOUSE (11-339): 1.14e-116: 345: 44.81
+	Hs
		962831 MDM2_HUMAN (1-491): 0: 710: 100.00		RASF6_HUMAN (134-339): 1.28e-65: 213: 22.73
+	Hs
		962849 MDM2_HUMAN (1-491): 0: 710: 100.00		RASF3_HUMAN (118-339): 2.62e-59: 192: 44.44
+	Rn
		88795 D3ZVH5_RAT (1-490): 0: 635: 78.16		RASF6_RAT (134-340): 1.33e-61: 201: 23.11