Protein: STK3
Serine/threonine-protein kinase 3 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 2) (MST-2) (STE20-like kinase MST2) (Serine/threonine-protein kinase Krs-1) [Cleaved into: Serine/threonine-protein kinase 3 36kDa subunit (MST2/N); Serine/threonine-protein kinase 3 20kDa subunit (MST2/C)]

Gene: STK3
Organism: Homo sapiens
Interactions: 199
UniProt ID: Q13188

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0001841 - neural tube formation
GO:0003157 - endocardium development
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1097750

RASF1
Ras association domain-containing protein 1

19

20

Small-scale

0.988

High

897635

RASF2
Ras association domain-containing protein 2

15

13

Small-scale

0.986

High

1097712

RASF5
Ras association domain-containing protein 5

11

13

Small-scale

0.982

High

1093098

STK4
Serine/threonine-protein kinase 4

11

19

Small-scale

0.980

High

349061

LATS1
Serine/threonine-protein kinase LATS1

9

20

Small-scale

0.968

High

1097658

STK3
Serine/threonine-protein kinase 3

7

17

Small-scale

0.964

High

1097690

RASF6
Ras association domain-containing protein 6

7

13

Small-scale

0.962

High

1097699

RASF3
Ras association domain-containing protein 3

6

13

Small-scale

0.946

High

400761

RAF1
RAF proto-oncogene serine/threonine-protein kinase

5

19

Small-scale

0.935

High

1097667

SLMAP
Sarcolemmal membrane-associated protein

4

20

Small-scale

0.911

High

919929

PLK1
Serine/threonine-protein kinase PLK1

4

20

Small-scale

0.899

High

1097735

RASF4
Ras association domain-containing protein 4

7

13

Small-scale

0.868

High

1097749

LATS2
Serine/threonine-protein kinase LATS2

3

19

Small-scale

0.834

High

728208

AKT1
RAC-alpha serine/threonine-protein kinase

2

16

Small-scale

0.834

High

913696

ZN133
Zinc finger protein 133

2

3

High-throughput

0.811

High

1097702

ZN695
Zinc finger protein 695

2

6

High-throughput

0.811

High

1097709

ZN420
Zinc finger protein 420

2

1

High-throughput

0.811

High

1097753

ZIM2
Zinc finger imprinted 2

2

9

High-throughput

0.811

High

1097737

SAV1
Protein salvador homolog 1

18

20

Small-scale

0.766

High

1097708

SNIP1
Smad nuclear-interacting protein 1

2

0

High-throughput

0.742

High

1097754

VAPA
Vesicle-associated membrane protein-associated protein A

5

5

High-throughput

0.725

High

1097693

MARK2
Serine/threonine-protein kinase MARK2

1

8

Small-scale

0.724

High

1097694

MOB1B
MOB kinase activator 1B

5

20

Small-scale

0.723

High

1097743

MOB1A
MOB kinase activator 1A

5

20

Small-scale

0.717

High

861144

MAP1B
Microtubule-associated protein 1B

4

10

High-throughput

0.699

High

1097685

MAP1S
Microtubule-associated protein 1S

4

9

High-throughput

0.699

High

1097764

FBW1A
F-box/WD repeat-containing protein 1A

4

15

Small-scale

0.697

High

302053

SEGN
Secretagogin

1

15

High-throughput

0.691

High

885761

KC1E
Casein kinase I isoform epsilon

1

13

High-throughput

0.691

High

1025259

CDK3
Cyclin-dependent kinase 3

1

12

High-throughput

0.691

High

1040281

DYST
Dystonin

1

18

High-throughput

0.691

High

1087649

M4K2
Mitogen-activated protein kinase kinase kinase kinase 2

1

16

High-throughput

0.691

High

1097665

RBM39
RNA-binding protein 39

1

2

High-throughput

0.691

High

1097678

ZN718
Zinc finger protein 718

1

4

High-throughput

0.691

High

1097698

ZN554
Zinc finger protein 554

1

8

High-throughput

0.691

High

1097720

AURKB
Aurora kinase B

1

14

High-throughput

0.691

High

1097758

FBW1B
F-box/WD repeat-containing protein 11

4

15

High-throughput

0.683

High

1097729

MLP3B
Microtubule-associated protein 1 light chain 3 beta

3

14

Small-scale

0.676

High

1093804

TRAF1
TNF receptor-associated factor 1

3

12

High-throughput

0.675

High

1097766

PHOCN
MOB-like protein phocein

3

20

Small-scale

0.660

High

443343

CDK1
Cyclin-dependent kinase 1

1

9

Small-scale

0.647

High

1097683

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

14

Small-scale

0.647

High

503578

TFPT
TCF3 fusion partner

3

0

High-throughput

0.646

High

327988

GBRAP
Gamma-aminobutyric acid receptor-associated protein

2

14

Small-scale

0.636

High

1097728

MLP3C
Microtubule-associated protein 1 light chain 3 gamma

2

14

Small-scale

0.636

High

615180

PACA
Pituitary adenylate cyclase-activating polypeptide

4

1

High-throughput

0.630

High

332986

VAPB
Vesicle-associated membrane protein-associated protein B/C

2

5

High-throughput

0.628

High

1097659

SKP2
S-phase kinase-associated protein 2

2

6

High-throughput

0.628

High

1097707

KIF2B
Kinesin-like protein KIF2B

2

10

High-throughput

0.628

High

1097687

EMB
Embigin

1

7

High-throughput

0.618

High

1097740

SLIK6
SLIT and NTRK-like protein 6

1

2

High-throughput

0.618

High

295029

ZN189
Zinc finger protein 189

1

3

High-throughput

0.618

High

578473

BRAF
Serine/threonine-protein kinase B-raf

1

14

Small-scale

0.618

High

854431

KPB2
Phosphorylase b kinase regulatory subunit alpha, liver isoform

1

4

High-throughput

0.618

High

1097668

KIF14
Kinesin-like protein KIF14

1

16

High-throughput

0.618

High

1097672

TAB1
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

1

9

High-throughput

0.618

High

1097689

TRI67
Tripartite motif-containing protein 67

1

19

High-throughput

0.618

High

1097717

KPBB
Phosphorylase b kinase regulatory subunit beta

1

4

High-throughput

0.618

High

1097738

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

8

High-throughput

0.618

High

1097739

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.618

High

1097756

ANFY1
Rabankyrin-5

1

8

High-throughput

0.618

High

1097733

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

2

14

Small-scale

0.613

High

228583

STRN
Striatin

2

20

High-throughput

0.611

High

729799

1433B
14-3-3 protein beta/alpha

2

20

High-throughput

0.611

High

1049252

1433F
14-3-3 protein eta

2

20

High-throughput

0.611

High

1092872

STRN3
Striatin-3

2

20

High-throughput

0.611

High

1097684

STRP1
Striatin-interacting protein 1

2

12

High-throughput

0.611

High

1097748

STRN4
Striatin-4

2

20

High-throughput

0.611

High

1097697

MOB3B
MOB kinase activator 3B

2

20

High-throughput

0.606

High

482241

PAEP
Glycodelin

2

2

High-throughput

0.601

High

1097742

PHAX
Phosphorylated adapter RNA export protein

2

0

High-throughput

0.598

High

1097744

PKHF2
Pleckstrin homology domain-containing family F member 2

1

3

High-throughput

0.594

High

1097671

PTN14
Tyrosine-protein phosphatase non-receptor type 14

2

8

Small-scale

0.584

High

1097718

FBXW7
F-box/WD repeat-containing protein 7

2

14

Small-scale

0.584

High

623316

RO52
E3 ubiquitin-protein ligase TRIM21

1

7

Small-scale

0.578

High

1097664

KEAP1
Kelch-like ECH-associated protein 1

1

7

Small-scale

0.578

High

563711

CFTR
Cystic fibrosis transmembrane conductance regulator

1

3

High-throughput

0.575

High

877100

KC1D
Casein kinase I isoform delta

1

7

High-throughput

0.575

High

943930

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

8

High-throughput

0.575

High

1097660

SQSTM
Sequestosome-1

1

5

High-throughput

0.575

High

1097661

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

1

Small-scale

0.561

High

1097701

ZDH17
Palmitoyltransferase ZDHHC17

1

12

High-throughput

0.553

High

1097719

CNKR1
Connector enhancer of kinase suppressor of ras 1

1

20

Small-scale

0.553

High

1097700

TRI69
E3 ubiquitin-protein ligase TRIM69

1

7

Small-scale

0.552

High

1097670

TAF1C
TATA box-binding protein-associated factor RNA polymerase I subunit C

2

1

High-throughput

0.549

High

1097706

FAM9B
Protein FAM9B

1

0

High-throughput

0.549

High

1097724

DCE1
Glutamate decarboxylase 1

1

0

High-throughput

0.549

High

1097726

CPNE1
Copine-1

1

1

High-throughput

0.541

High

123685

MYO1C
Unconventional myosin-Ic

1

15

High-throughput

0.536

High

215814

P52K
52 kDa repressor of the inhibitor of the protein kinase

1

3

High-throughput

0.536

High

418656

GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2

1

4

High-throughput

0.536

High

475958

GNAI3
Guanine nucleotide-binding protein G(i) subunit alpha-3

1

4

High-throughput

0.536

High

635523

NEBU
Nebulin

1

20

High-throughput

0.536

High

966268

1433G
14-3-3 protein gamma

1

20

High-throughput

0.536

High

984096

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

5

High-throughput

0.536

High

989836

GNAI1
Guanine nucleotide-binding protein G(i) subunit alpha-1

1

4

High-throughput

0.536

High

1007681

RAE1L
mRNA export factor RAE1

1

4

High-throughput

0.536

High

1028753

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

12

High-throughput

0.536

High

1094168

ACACA
Acetyl-CoA carboxylase 1

1

10

High-throughput

0.536

High

1097675

DREB
Drebrin

1

14

High-throughput

0.536

High

1097679

GLYR1
Cytokine-like nuclear factor N-PAC

1

4

High-throughput

0.536

High

1097688

CC174
Coiled-coil domain-containing protein 174

1

1

High-throughput

0.536

High

1097703

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

2

High-throughput

0.536

High

1097725

KIF2C
Kinesin-like protein KIF2C

1

17

High-throughput

0.536

High

1097732

IQCN
IQ domain-containing protein N

1

1

High-throughput

0.536

High

1097734

TSYL1
Testis-specific Y-encoded-like protein 1

1

1

High-throughput

0.536

High

1097736

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

14

High-throughput

0.536

High

1097741

EGLN3
Prolyl hydroxylase EGLN3

1

2

High-throughput

0.536

High

1097745

CYBP
Calcyclin-binding protein

1

2

High-throughput

0.536

High

1097746

CAN10
Calpain-10

1

2

High-throughput

0.536

High

1097761

ABT1
Activator of basal transcription 1

1

3

High-throughput

0.536

High

1097763

CLC11
C-type lectin domain family 11 member A

1

1

High-throughput

0.536

High

952145

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

14

High-throughput

0.527

High

828358

PEX19
Peroxisomal biogenesis factor 19

1

0

High-throughput

0.518

High

943840

CF298
Cilia- and flagella-associated protein 298

1

0

High-throughput

0.513

High

1097669

TAF13
Transcription initiation factor TFIID subunit 13

1

0

High-throughput

0.513

High

1097696

CENPV
Centromere protein V

1

0

High-throughput

0.513

High

1097727

CENPO
Centromere protein O

1

0

High-throughput

0.513

High

1097747

RM40
Large ribosomal subunit protein mL40

1

0

High-throughput

0.513

High

1097768

ATG4B
Cysteine protease ATG4B

1

0

High-throughput

0.513

High

736916

GBP2
Guanylate-binding protein 2

1

1

High-throughput

0.508

High

1097716

FUBP2
Far upstream element-binding protein 2

1

5

High-throughput

0.508

High

185653

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

7

High-throughput

0.501

High

388065

MBP
Myelin basic protein

1

2

Small-scale

0.501

High

622161

NDUV2
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial

1

1

High-throughput

0.489

High

1097673

AINX
Alpha-internexin

1

7

High-throughput

0.489

High

1097767

NOP16
Nucleolar protein 16

1

1

High-throughput

0.489

High

868152

SYQ
Glutamine--tRNA ligase

1

0

High-throughput

0.486

High

962941

CH10
10 kDa heat shock protein, mitochondrial

1

1

High-throughput

0.481

High

1055549

ST2A1
Sulfotransferase 2A1

1

1

High-throughput

0.481

High

1097704

Z3H7A
Zinc finger CCCH domain-containing protein 7A

1

12

High-throughput

0.481

High

1097721

GMCL1
Germ cell-less protein-like 1

1

7

High-throughput

0.481

High

1097662

4EBP1
Eukaryotic translation initiation factor 4E-binding protein 1

1

0

Small-scale

0.480

High

164565

TNPO2
Transportin-2

1

5

Small-scale

0.479

High

172766

XPO1
Exportin-1

1

14

High-throughput

0.479

High

176609

KIF3B
Kinesin-like protein KIF3B

1

7

High-throughput

0.479

High

216426

SUV91
Histone-lysine N-methyltransferase SUV39H1

1

2

High-throughput

0.479

High

239050

ZNRD2
Protein ZNRD2

1

1

Small-scale

0.479

High

287915

MYCB2
E3 ubiquitin-protein ligase MYCBP2

1

6

Small-scale

0.479

High

315542

RECQ4
ATP-dependent DNA helicase Q4

1

6

High-throughput

0.479

High

321230

ERLN2
Erlin-2

1

2

High-throughput

0.479

High

341936

CEP43
Centrosomal protein 43

1

2

High-throughput

0.479

High

345750

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

5

High-throughput

0.479

High

535935

MYH3
Myosin-3

1

16

High-throughput

0.479

High

556849

MYH1
Myosin-1

1

16

High-throughput

0.479

High

556921

MYH7
Myosin-7

1

16

High-throughput

0.479

High

563009

MYH6
Myosin-6

1

16

High-throughput

0.479

High

563053

MYH8
Myosin-8

1

16

High-throughput

0.479

High

652504

NR4A1
Nuclear receptor subfamily 4immunitygroup A member 1

1

11

Small-scale

0.479

High

690967

1433T
14-3-3 protein theta

1

20

High-throughput

0.479

High

785133

RL4
Large ribosomal subunit protein uL4

1

4

High-throughput

0.479

High

934553

TERA
Transitional endoplasmic reticulum ATPase

1

6

High-throughput

0.479

High

942594

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

15

High-throughput

0.479

High

971474

1433E
14-3-3 protein epsilon

1

8

High-throughput

0.479

High

989729

GNAS2
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

1

5

High-throughput

0.479

High

991511

DYL1
Dynein light chain 1, cytoplasmic

1

8

Small-scale

0.479

High

1057134

PRDX1
Peroxiredoxin-1

1

5

High-throughput

0.479

High

1097663

CUL3
Cullin-3

1

3

High-throughput

0.479

High

1097666

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

5

Small-scale

0.479

High

1097677

CL16A
Protein CLEC16A

1

4

High-throughput

0.479

High

1097691

CE128
Centrosomal protein of 128 kDa

1

20

High-throughput

0.479

High

1097695

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

6

High-throughput

0.479

High

1097710

RN128
E3 ubiquitin-protein ligase RNF128

1

1

Small-scale

0.479

High

1097714

RIN2
Ras and Rab interactor 2

1

10

High-throughput

0.479

High

1097715

GOGA1
Golgin subfamily A member 1

1

18

High-throughput

0.479

High

1097722

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

19

Small-scale

0.479

High

1097751

FGOP2
FGFR1 oncogene partner 2

1

14

High-throughput

0.479

High

1097752

NDE1
Nuclear distribution protein nudE homolog 1

1

18

Small-scale

0.479

High

1097755

CT2NL
CTTNBP2 N-terminal-like protein

1

20

High-throughput

0.479

High

1097759

MYH2
Myosin-2

1

16

High-throughput

0.479

High

1097760

MYH13
Myosin-13

1

16

High-throughput

0.479

High

1097762

MTMR7
Phosphatidylinositol-3-phosphate phosphatase MTMR7

1

1

High-throughput

0.479

High

1097765

MYH15
Myosin-15

1

16

High-throughput

0.479

High

1097680

Q53SE7
Germ cell-less homolog 1

1

7

High-throughput

0.470

High

1097713

JPH3
Junctophilin-3

1

3

High-throughput

0.470

High

1023932

EM55
55 kDa erythrocyte membrane protein

1

7

High-throughput

0.464

High

229525

NRDC
Nardilysin

1

0

Small-scale

0.458

High

945140

CORO7
Coronin-7

1

0

Small-scale

0.458

High

945220

NU107
Nuclear pore complex protein Nup107

1

0

Small-scale

0.458

High

1097676

IF16
Gamma-interferon-inducible protein 16

1

0

High-throughput

0.458

High

1097711

NU133
Nuclear pore complex protein Nup133

1

0

Small-scale

0.458

High

1097731

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.458

High

351275

TTLL1
Polyglutamylase complex subunit TTLL1

1

1

High-throughput

0.445

High

1097682

GNAS1
Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas

1

5

High-throughput

0.445

High

1097692

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

15

High-throughput

0.445

High

1097730

WWTR1
WW domain-containing transcription regulator protein 1

1

20

Small-scale

0.445

High

1097681

FREM1
FRAS1-related extracellular matrix protein 1

1

4

High-throughput

0.437

High

1097686

RNF43
E3 ubiquitin-protein ligase RNF43

1

2

High-throughput

0.437

High

1097757

BIN2
Bridging integrator 2

1

3

Small-scale

0.437

High

1097705

UBR2
E3 ubiquitin-protein ligase UBR2

1

0

High-throughput

0.426

High

379350

IGHG2
Immunoglobulin heavy constant gamma 2

1

10

High-throughput

0.407

High

379511

IGHM
Immunoglobulin heavy constant mu

1

8

High-throughput

0.407

High

624706

A1AG2
Alpha-1-acid glycoprotein 2

1

0

High-throughput

0.282

High

586374

ARSB
Arylsulfatase B

1

0

High-throughput

0.279

Low

1097723

RUN3B
RUN domain-containing protein 3B

1

0

High-throughput

0.279

Low

350291

DDAH2
Putative hydrolase DDAH2

1

0

High-throughput

0.265

Low

1097674

TAZ
Tafazzin

1

0

Small-scale

0.249

Low

1063040

S20A2
Sodium-dependent phosphate transporter 2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025