HitPredict

Interactor 1: E2F1 (Q01094)
Transcription factor E2F1 (E2F-1) (PBR3) (Retinoblastoma-associated protein 1) (RBAP-1) (Retinoblastoma-binding protein 3) (RBBP-3) (pRB-binding protein E2F-1)
Gene: E2F1

Interactor 2: TFDP1 (Q14186)
Transcription factor Dp-1 (DRTF1-polypeptide 1) (DRTF1) (E2F dimerization partner 1)
Gene: TFDP1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 1.00 0.991

The method score is based on:

Property Details
Experiments 25368385, 9501179, 28542143, 30867845, 31130363, 9780002, 7739537, 8405995, 35140242, 15133492, 27705803, 24981860, 7892279, 22629304, 9199321, 8816798, 9704927, 8657117, 9464260, 34591642 and 3 others

more...
Identification Methods affinity chromatography technology, pull down, proximity labelling technology, two hybrid, coimmunoprecipitation, comigration in non denaturing gel electrophoresis, experimental interaction detection, anti tag coimmunoprecipitation, tandem affinity purification, two hybrid array and 1 others

more...
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains DP~E2F_CC-MB, E2F_TDP~E2F_TDP
Common GO terms GO:0000785 - chromatin
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0000987 - cis-regulatory region sequence-specific DNA binding
GO:0003700 - DNA-binding transcription factor activity
GO:0005634 - nucleus
and 10 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 437
Hs

1 410
+ Mm
+ Hs
+ Hs
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs
+ Mm
+ Hs
+ Hs
+ Mm
+ Hs
+ Hs
+ Mm
+ Mm
+ At
+ At
+ At
+ At

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024