Protein: CD5R1
Cyclin-dependent kinase 5 activator 1 (CDK5 activator 1) (Cyclin-dependent kinase 5 regulatory subunit 1) (TPKII regulatory subunit) [Cleaved into: Cyclin-dependent kinase 5 activator 1, p35 (p35); Cyclin-dependent kinase 5 activator 1, p25 (p25) (Tau protein kinase II 23 kDa subunit) (p23)]

Gene: CD5R1, CDK5R1
Organism: Homo sapiens
Interactions: 74
UniProt ID: Q15078

Gene Ontology (top 5):
GO:0000079 - regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000226 - microtubule cytoskeleton organization
GO:0000307 - cyclin-dependent protein kinase holoenzyme complex
GO:0001764 - neuron migration
GO:0002020 - protease binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1025461

CDK5
Cyclin-dependent kinase 5

20

7

Small-scale

0.990

High

667860

CDK2
Cyclin-dependent kinase 2

4

7

Small-scale

0.895

High

897824

CDK9
Cyclin-dependent kinase 9

2

5

Small-scale

0.754

High

1025545

CDK16
Cyclin-dependent kinase 16

1

7

Small-scale

0.740

High

891562

GSK3B
Glycogen synthase kinase-3 beta

1

3

Small-scale

0.724

High

1142273

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

1

0

Small-scale

0.702

High

1142241

MTUS2
Microtubule-associated tumor suppressor candidate 2

3

2

High-throughput

0.667

High

220692

DENR
Density-regulated protein

3

0

High-throughput

0.638

High

1031103

HMCS1
Hydroxymethylglutaryl-CoA synthase, cytoplasmic

3

0

High-throughput

0.638

High

1142268

UBE2T
Ubiquitin-conjugating enzyme E2 T

3

0

High-throughput

0.638

High

1142266

NEK6
Serine/threonine-protein kinase Nek6

1

0

High-throughput

0.630

High

549159

CDK4
Cyclin-dependent kinase 4

1

8

Small-scale

0.618

High

1025266

CDK3
Cyclin-dependent kinase 3

1

7

Small-scale

0.618

High

1025351

CDK6
Cyclin-dependent kinase 6

1

8

Small-scale

0.618

High

883048

AMPH
Amphiphysin

2

0

Small-scale

0.603

High

1142252

MB12A
Multivesicular body subunit 12A

2

0

High-throughput

0.602

High

764765

CTNB1
Catenin beta-1

2

0

Small-scale

0.598

High

321094

PLPHP
Pyridoxal phosphate homeostasis protein

2

0

High-throughput

0.585

High

464159

TPM2
Tropomyosin beta chain

2

0

High-throughput

0.585

High

1142245

NT2NA
Notch homolog 2 N-terminal-like protein A

2

2

High-throughput

0.576

High

555689

ACTN1
Alpha-actinin-1

1

1

Small-scale

0.573

High

1142244

LMTK1
Serine/threonine-protein kinase LMTK1

1

4

Small-scale

0.573

High

1029295

SET
Protein SET

1

0

Small-scale

0.537

High

1134792

ODFP1
Outer dense fiber protein 1

1

0

Small-scale

0.537

High

1142250

RSPRY
RING finger and SPRY domain-containing protein 1

1

1

High-throughput

0.536

High

1142261

SEPT5
Septin-5

1

2

Small-scale

0.527

High

1142274

T22D4
TSC22 domain family protein 4

1

0

High-throughput

0.518

High

1046361

UBXN1
UBX domain-containing protein 1

1

0

High-throughput

0.513

High

1085126

SCRN1
Secernin-1

1

0

High-throughput

0.513

High

1142260

CDCA3
Cell division cycle-associated protein 3

1

0

High-throughput

0.513

High

323936

CMTA2
Calmodulin-binding transcription activator 2

1

0

High-throughput

0.493

High

596570

EPCAM
Epithelial cell adhesion molecule

1

0

High-throughput

0.493

High

688563

NKG2A
NKG2-A/NKG2-B type II integral membrane protein

1

0

High-throughput

0.493

High

848201

MAGA2
Melanoma-associated antigen 2

1

0

High-throughput

0.493

High

880011

DNSL1
Deoxyribonuclease-1-like 1

1

0

High-throughput

0.493

High

1040131

M2OM
Mitochondrial 2-oxoglutarate/malate carrier protein

1

0

High-throughput

0.493

High

1142243

CREL2
Protein disulfide isomerase CRELD2

1

0

High-throughput

0.493

High

1142247

PIAS4
E3 SUMO-protein ligase PIAS4

1

0

High-throughput

0.493

High

1142248

MFI
Protein MFI

1

0

High-throughput

0.493

High

1142251

RAB3C
Ras-related protein Rab-3C

1

0

High-throughput

0.493

High

1142256

PRAM
PML-RARA-regulated adapter molecule 1

1

0

High-throughput

0.493

High

1142263

THAP7
THAP domain-containing protein 7

1

0

High-throughput

0.493

High

1142267

MYNN
Myoneurin

1

0

High-throughput

0.493

High

1142271

TPX2
Targeting protein for Xklp2

1

0

High-throughput

0.493

High

1142242

K1C40
Keratin, type I cytoskeletal 40

1

1

High-throughput

0.481

High

1142246

SIAH1
E3 ubiquitin-protein ligase SIAH1

1

2

High-throughput

0.481

High

1142270

BL1S6
Biogenesis of lysosome-related organelles complex 1 subunit 6

1

1

High-throughput

0.481

High

422126

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

461492

HS90A
Heat shock protein HSP 90-alpha

1

0

Small-scale

0.480

High

529824

TAU
Microtubule-associated protein tau

1

0

Small-scale

0.480

High

861614

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

0

High-throughput

0.480

High

1142254

CK5P3
CDK5 regulatory subunit-associated protein 3

1

0

Small-scale

0.480

High

1142258

CK5P2
CDK5 regulatory subunit-associated protein 2

1

0

Small-scale

0.480

High

1142259

CK5P1
Mitochondrial tRNA methylthiotransferase CDK5RAP1

1

0

Small-scale

0.480

High

556090

CADH1
Cadherin-1

1

1

Small-scale

0.479

High

808072

CDN1A
Cyclin-dependent kinase inhibitor 1

1

1

Small-scale

0.479

High

857330

CDN1B
Cyclin-dependent kinase inhibitor 1B

1

1

Small-scale

0.479

High

876589

NEST
Nestin

1

1

Small-scale

0.479

High

1142257

NEB2
Neurabin-2

1

1

High-throughput

0.479

High

1142272

FZR1
Fizzy-related protein homolog

1

1

High-throughput

0.479

High

949881

KR103
Keratin-associated protein 10-3

1

0

High-throughput

0.460

High

1142264

B2L13
Bcl-2-like protein 13

1

0

Small-scale

0.460

High

613047

EGR1
Early growth response protein 1

1

0

Small-scale

0.458

High

659083

PTPRZ
Receptor-type tyrosine-protein phosphatase zeta

1

0

Small-scale

0.458

High

685006

DNMT1
DNA

1

0

Small-scale

0.458

High

1109743

HDAC1
Histone deacetylase 1

1

0

Small-scale

0.458

High

1142249

Q96BE0
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.437

High

1142255

FEM1C
Protein fem-1 homolog C

1

1

Small-scale

0.408

High

1142269

FEM1B
Protein fem-1 homolog B

1

1

Small-scale

0.408

High

1142253

MMAB
Corrinoid adenosyltransferase MMAB

1

0

High-throughput

0.279

Low

60834

MBPHL
Myosin-binding protein H-like

1

0

High-throughput

0.268

Low

1142262

Q9BQ29
THAP4 protein

1

0

High-throughput

0.268

Low

1142240

Q53FC7
Heat shock 70 kDa protein 6

1

0

High-throughput

0.249

Low

1142265

Q9HAV2
Heat shock transcription factor 1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025