HitPredict

Interactor 1: RUNX1 (Q01196)
Runt-related transcription factor 1 (Acute myeloid leukemia 1 protein) (Core-binding factor subunit alpha-2) (CBF-alpha-2) (Oncogene AML-1) (Polyomavirus enhancer-binding protein 2 alpha B subunit) (PEA2-alpha B) (PEBP2-alpha B) (SL3-3 enhancer factor 1 alpha B subunit) (SL3/AKV core-binding factor alpha B subunit)
Gene: RUNX1

Interactor 2: TLE3 (Q04726)
Transducin-like enhancer protein 3 (Enhancer of split groucho-like protein 3) (ESG3)
Gene: TLE3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	34551306, 37689310
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 453 Hs			1 772
+	Hs
		964303 RUNX1_HUMAN (1-453): 0: 702: 100.00		TLE1_HUMAN (1-772): 0: 538: 77.42
+	Hs
		980600 RUNX3_HUMAN (1-453): 0: 540: 57.84		TLE1_HUMAN (1-772): 0: 538: 77.42
+	Mm
		996430 RUNX2_MOUSE (43-453): 0: 539: 64.11		TLE1_MOUSE (1-772): 1.82e-174: 522: 78.22
+	Hs
		980602 RUNX2_HUMAN (43-453): 0: 522: 64.56		TLE1_HUMAN (1-772): 0: 538: 77.42
+	Hs
		964308 RUNX1_HUMAN (1-453): 0: 702: 100.00		TLE5_HUMAN (1-200): 1.22e-100: 310: 62.19
+	Mm
		903659 Q3UM65_MOUSE (6-453): 0: 679: 95.76		WDR5_MOUSE (284-560): 2.42e-32: 130: 9.12
+	Dm
		558358 RUNT_DROME (34-178): 2.37e-66: 222: 63.45		GROU_DROME (1-772): 4.17e-136: 421: 57.20
+	Hs
		921560 RUNX2_HUMAN (43-453): 0: 522: 64.56		GBB2_HUMAN (688-771): 3.6e-14: 76.4: 16.47
+	Ce
		107827 RUNX1_CAEEL (48-177): 1.01e-59: 199: 50.00		UNC37_CAEEL (18-686): 7.48e-82: 275: 17.09