Protein: PLD1
Phospholipase D1 (PLD 1) (hPLD1) (EC 3.1.4.4) (Choline phosphatase 1) (Phosphatidylcholine-hydrolyzing phospholipase D1)

Gene: PLD1
Organism: Homo sapiens
Interactions: 129
UniProt ID: Q13393

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0004630 - phospholipase D activity
GO:0005765 - lysosomal membrane
GO:0005768 - endosome
GO:0005789 - endoplasmic reticulum membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

900438

RHOA
Transforming protein RhoA

4

4

Small-scale

0.902

High

912886

ARF6
ADP-ribosylation factor 6

3

2

Small-scale

0.827

High

893967

CDC42
Cell division control protein 42 homolog

2

4

Small-scale

0.806

High

506383

RALA
Ras-related protein Ral-A

2

4

Small-scale

0.778

High

1033006

OSBL5
Oxysterol-binding protein-related protein 5

2

0

High-throughput

0.770

High

1032996

ARL11
ADP-ribosylation factor-like protein 11

1

4

High-throughput

0.761

High

915649

RHOB
Rho-related GTP-binding protein RhoB

2

5

High-throughput

0.754

High

950485

ARF1
ADP-ribosylation factor 1

2

2

Small-scale

0.754

High

1032967

RHEB
GTP-binding protein Rheb

1

3

Small-scale

0.747

High

1032990

ARL14
ADP-ribosylation factor-like protein 14

1

3

High-throughput

0.747

High

1032968

PKN1
Serine/threonine-protein kinase N1

1

4

Small-scale

0.724

High

1032978

PKN3
Serine/threonine-protein kinase N3

1

5

Small-scale

0.724

High

713798

RYK
Tyrosine-protein kinase RYK

1

2

High-throughput

0.691

High

1033023

TX264
Testis-expressed protein 264

3

1

High-throughput

0.667

High

131243

BIN1
Myc box-dependent-interacting protein 1

1

3

Small-scale

0.647

High

522963

SRC
Proto-oncogene tyrosine-protein kinase Src

1

3

Small-scale

0.647

High

1032971

DDR2
Discoidin domain-containing receptor 2

1

3

High-throughput

0.646

High

1032982

RHEX
Regulator of hemoglobinization and erythroid cell expansion protein

3

0

High-throughput

0.638

High

1032964

PEA15
Astrocytic phosphoprotein PEA-15

2

1

Small-scale

0.633

High

702759

CADH5
Cadherin-5

2

2

High-throughput

0.628

High

1032992

GP156
Probable G-protein coupled receptor 156

2

1

High-throughput

0.628

High

1033011

TNR19
Tumor necrosis factor receptor superfamily member 19

2

1

High-throughput

0.628

High

1033014

C5AR2
C5a anaphylatoxin chemotactic receptor 2

2

4

High-throughput

0.628

High

618071

COF1
Cofilin-1

2

1

Small-scale

0.624

High

350139

RASK
GTPase KRas

1

5

High-throughput

0.618

High

374176

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

5

High-throughput

0.618

High

433744

LYN
Tyrosine-protein kinase Lyn

1

3

High-throughput

0.618

High

545354

RAC2
Ras-related C3 botulinum toxin substrate 2

1

4

High-throughput

0.618

High

562644

PLCG2
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

1

2

Small-scale

0.618

High

564509

RHOQ
Rho-related GTP-binding protein RhoQ

1

5

High-throughput

0.618

High

566382

KPCA
Protein kinase C alpha type

1

2

Small-scale

0.618

High

844506

RAB5C
Ras-related protein Rab-5C

1

1

High-throughput

0.618

High

844908

RAB7A
Ras-related protein Rab-7a

1

3

High-throughput

0.618

High

845464

RAB9A
Ras-related protein Rab-9A

1

3

High-throughput

0.618

High

895062

RAB2A
Ras-related protein Rab-2A

1

1

High-throughput

0.618

High

1032966

RAB35
Ras-related protein Rab-35

1

1

High-throughput

0.618

High

1032991

KCD17
BTB/POZ domain-containing protein KCTD17

3

1

High-throughput

0.609

High

914047

RB11A
Ras-related protein Rab-11A

1

0

High-throughput

0.586

High

1032962

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.586

High

1032998

SNX27
Sorting nexin-27

1

0

High-throughput

0.586

High

580999

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

1

2

Small-scale

0.584

High

1033015

CCG5
Voltage-dependent calcium channel gamma-5 subunit

2

2

High-throughput

0.574

High

771948

VHL
von Hippel-Lindau disease tumor suppressor

1

1

Small-scale

0.561

High

827744

AMPH
Amphiphysin

1

3

Small-scale

0.561

High

929847

ACTG
Actin, cytoplasmic 2

1

2

Small-scale

0.561

High

1033005

EGLN1
Egl nine homolog 1

1

1

Small-scale

0.561

High

850648

KS6A3
Ribosomal protein S6 kinase alpha-3

1

1

Small-scale

0.553

High

1032973

DCAF6
DDB1- and CUL4-associated factor 6

1

1

High-throughput

0.553

High

1033009

ANLN
Anillin

1

1

High-throughput

0.553

High

742276

SYUA
Alpha-synuclein

1

0

Small-scale

0.537

High

165976

PER2
Period circadian protein homolog 2

1

2

High-throughput

0.536

High

364881

FRIL
Ferritin light chain

1

1

High-throughput

0.536

High

895617

CXCR4
C-X-C chemokine receptor type 4

1

3

High-throughput

0.536

High

1032969

ASIC2
Acid-sensing ion channel 2

1

1

High-throughput

0.536

High

1032999

LURA1
Leucine rich adaptor protein 1

1

1

High-throughput

0.536

High

1033000

TMM74
Transmembrane protein 74

1

1

High-throughput

0.536

High

1032984

RHG22
Rho GTPase-activating protein 22

1

0

High-throughput

0.517

High

394668

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.515

High

179173

COPT1
High affinity copper uptake protein 1

1

0

High-throughput

0.513

High

216505

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

1

0

High-throughput

0.513

High

274997

RENR
Renin receptor

1

0

High-throughput

0.513

High

302393

CSTN1
Calsyntenin-1

1

0

High-throughput

0.513

High

608226

KCNA4
Potassium voltage-gated channel subfamily A member 4

1

0

High-throughput

0.513

High

617535

CRCM
Colorectal mutant cancer protein

1

0

High-throughput

0.513

High

672662

CD6
T-cell differentiation antigen CD6

1

0

High-throughput

0.513

High

679229

KAP1
cAMP-dependent protein kinase type I-beta regulatory subunit

1

0

High-throughput

0.513

High

1032961

LTBP2
Latent-transforming growth factor beta-binding protein 2

1

0

High-throughput

0.513

High

1032974

FAXC
Failed axon connections homolog

1

0

High-throughput

0.513

High

1033002

APBA2
Amyloid-beta A4 precursor protein-binding family A member 2

1

0

High-throughput

0.513

High

1033013

CSC1
Calcium permeable stress-gated cation channel 1

1

0

High-throughput

0.513

High

1033017

AKA11
A-kinase anchor protein 11

1

0

High-throughput

0.513

High

1032970

HIF1A
Hypoxia-inducible factor 1-alpha

1

1

Small-scale

0.512

High

893791

S10AA
Protein S100-A10

1

0

High-throughput

0.493

High

1032995

LMO7
LIM domain only protein 7

1

0

High-throughput

0.493

High

174391

FANCG
Fanconi anemia group G protein

1

0

High-throughput

0.493

High

997247

SPIR1
Protein spire homolog 1

1

0

High-throughput

0.493

High

1033007

SYNCI
Syncoilin

1

0

High-throughput

0.493

High

279294

DNJB5
DnaJ homolog subfamily B member 5

1

6

High-throughput

0.489

High

796069

MAGA9
Melanoma-associated antigen 9

1

1

High-throughput

0.489

High

1025624

EI2BE
Translation initiation factor eIF2B subunit epsilon

1

1

High-throughput

0.489

High

1032965

TEBP
Prostaglandin E synthase 3

1

2

High-throughput

0.489

High

1032972

INSY1
Inhibitory synaptic factor 1

1

1

High-throughput

0.489

High

1032993

ZCH10
Zinc finger CCHC domain-containing protein 10

1

1

High-throughput

0.489

High

119959

AP3B1
AP-3 complex subunit beta-1

1

2

High-throughput

0.479

High

176182

PPM1G
Protein phosphatase 1G

1

1

High-throughput

0.479

High

507001

LAMP1
Lysosome-associated membrane glycoprotein 1

1

2

High-throughput

0.479

High

527438

LAMP2
Lysosome-associated membrane glycoprotein 2

1

2

High-throughput

0.479

High

1032723

AP3B2
AP-3 complex subunit beta-2

1

2

High-throughput

0.479

High

1032986

PLD3
5'-3' exonuclease PLD3

1

1

High-throughput

0.479

High

1033018

LAMP3
Lysosome-associated membrane glycoprotein 3

1

2

High-throughput

0.479

High

1033020

AP3M1
AP-3 complex subunit mu-1

1

2

High-throughput

0.479

High

1032977

ESRP1
Epithelial splicing regulatory protein 1

1

1

High-throughput

0.470

High

167909

NPC1
NPC intracellular cholesterol transporter 1

1

0

High-throughput

0.458

High

196299

PJA2
E3 ubiquitin-protein ligase Praja-2

1

0

High-throughput

0.458

High

386669

P53
Cellular tumor antigen p53

1

0

High-throughput

0.458

High

670010

MARCS
Myristoylated alanine-rich C-kinase substrate

1

0

High-throughput

0.458

High

1032976

LTOR1
Ragulator complex protein LAMTOR1

1

0

High-throughput

0.458

High

1032988

CXD3
Gap junction delta-3 protein

1

0

High-throughput

0.458

High

1032994

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

1033016

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

56616

PIPSL
Putative PIP5K1A and PSMD4-like protein

1

1

High-throughput

0.445

High

887834

CD81
CD81 antigen

1

1

High-throughput

0.445

High

1032987

ANKY2
Ankyrin repeat and MYND domain-containing protein 2

1

1

High-throughput

0.437

High

1033010

EI2BG
Translation initiation factor eIF2B subunit gamma

1

1

High-throughput

0.437

High

901781

STXB1
Syntaxin-binding protein 1

1

0

Small-scale

0.433

High

307805

ZRAB2
Zinc finger Ran-binding domain-containing protein 2

3

0

High-throughput

0.347

High

1032989

MIER2
Mesoderm induction early response protein 2

3

0

High-throughput

0.347

High

1033004

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

3

0

High-throughput

0.347

High

1033008

SACA1
Sperm acrosome membrane-associated protein 1

3

0

High-throughput

0.347

High

1032997

SIR1
NAD-dependent protein deacetylase sirtuin-1

2

0

High-throughput

0.318

High

622239

ALAT1
Alanine aminotransferase 1

1

0

High-throughput

0.279

Low

1032975

CP135
Centrosomal protein of 135 kDa

1

0

High-throughput

0.279

Low

1032981

ANKS3
Ankyrin repeat and SAM domain-containing protein 3

1

0

High-throughput

0.279

Low

1032983

HEAT3
HEAT repeat-containing protein 3

1

0

High-throughput

0.279

Low

1033001

CC85A
Coiled-coil domain-containing protein 85A

1

0

High-throughput

0.279

Low

1033003

BACH2
Transcription regulator protein BACH2

1

0

High-throughput

0.279

Low

1033012

ING3
Inhibitor of growth protein 3

1

0

High-throughput

0.279

Low

1033019

POLH
DNA polymerase eta

1

0

High-throughput

0.279

Low

551518

TFE2
Transcription factor E2-alpha

1

0

High-throughput

0.268

Low

1012229

INCA1
Protein INCA1

1

0

High-throughput

0.268

Low

1018943

TP53B
TP53-binding protein 1

1

0

High-throughput

0.268

Low

1032979

ASCL4
Achaete-scute homolog 4

1

0

High-throughput

0.268

Low

1032980

LIAT1
Protein LIAT1

1

0

High-throughput

0.268

Low

64530

ZSWM8
Zinc finger SWIM domain-containing protein 8

1

0

High-throughput

0.249

Low

150978

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

0

High-throughput

0.249

Low

1032963

BRD3
Bromodomain-containing protein 3

1

0

High-throughput

0.249

Low

1032985

ZCH18
Zinc finger CCCH domain-containing protein 18

1

0

High-throughput

0.249

Low

1033021

DCAF1
DDB1- and CUL4-associated factor 1

1

0

High-throughput

0.249

Low

1033022

CFA20
Cilia- and flagella-associated protein 20

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024