HitPredict

Interactor 1: AKT1 (Q01314)
RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase B) (PKB) (Protein kinase B alpha) (PKB alpha) (RAC-PK-alpha)
Gene: AKT1

Interactor 2: HS90B (Q76LV1)
Heat shock protein HSP 90-beta
Gene: HSP90AB1

Species: Bos taurus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	15782121
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 480 Bt			1 724
+	Mm
		513660 AKT1_MOUSE (1-480): 0: 605: 97.50		HS90B_MOUSE (1-724): 0: 1090: 99.72
+	Hs
		437927 AKT1_HUMAN (1-480): 0: 601: 96.88		HS90B_HUMAN (1-724): 0: 1087: 99.59
+	Rn
		812703 AKT1_RAT (1-480): 0: 605: 97.71		HS90A_RAT (1-724): 0: 1070: 84.58
+	Hs
		431572 AKT1_HUMAN (1-480): 0: 601: 96.88		HS90A_HUMAN (1-724): 0: 1073: 85.38
+	Mm
		432411 AKT1_MOUSE (1-480): 0: 605: 97.50		HS90A_MOUSE (1-724): 0: 1068: 84.45
+	Hs
		437928 AKT2_HUMAN (1-477): 0: 572: 82.05		HS90B_HUMAN (1-724): 0: 1087: 99.59
+	Hs
		438633 AKT3_HUMAN (1-478): 0: 567: 82.08		HS90B_HUMAN (1-724): 0: 1087: 99.59
+	Hs
		431573 AKT2_HUMAN (1-477): 0: 572: 82.05		HS90A_HUMAN (1-724): 0: 1073: 85.38
+	Hs
		432376 AKT3_HUMAN (1-478): 0: 567: 82.08		HS90A_HUMAN (1-724): 0: 1073: 85.38
+	Hs
		437907 KPCL_HUMAN (107-477): 9.63e-152: 449: 42.25		HS90B_HUMAN (1-724): 0: 1087: 99.59
+	Hs
		438085 KPCE_HUMAN (69-474): 5.51e-148: 441: 41.08		HS90B_HUMAN (1-724): 0: 1087: 99.59
+	Hs
		431548 KPCL_HUMAN (107-477): 9.63e-152: 449: 42.25		HS90A_HUMAN (1-724): 0: 1073: 85.38
+	Hs
		538122 AKT1_HUMAN (1-480): 0: 601: 96.88		ENPL_HUMAN (3-696): 0: 914: 46.38
+	Hs
		431752 KPCE_HUMAN (69-474): 5.51e-148: 441: 41.08		HS90A_HUMAN (1-724): 0: 1073: 85.38
+	Rn
		448409 KPCD_RAT (17-477): 1.6e-148: 441: 34.40		HS90A_RAT (1-724): 0: 1070: 84.58
+	Hs
		538446 AKT3_HUMAN (1-478): 0: 567: 82.08		ENPL_HUMAN (3-696): 0: 914: 46.38
+	Hs
		681885 AKT1_HUMAN (1-480): 0: 601: 96.88		H90B3_HUMAN (1-724): 0: 813: 75.69
+	Hs
		1123464 AKT3_HUMAN (1-478): 0: 567: 82.08		H90B3_HUMAN (1-724): 0: 813: 75.69
+	Hs
		1123447 AKT3_HUMAN (1-478): 0: 567: 82.08		H90B4_HUMAN (25-596): 0: 637: 71.68
+	Hs
		1162538 AKT3_HUMAN (1-478): 0: 567: 82.08		Q6PK50_HUMAN (1-350): 0: 617: 99.43