Protein: PSME1
Proteasome activator complex subunit 1 (11S regulator complex subunit alpha) (REG-alpha) (Activator of multicatalytic protease subunit 1) (Interferon gamma up-regulated I-5111 protein) (IGUP I-5111) (Proteasome activator 28 subunit alpha) (PA28a) (PA28alpha)

Gene: PSME1
Organism: Homo sapiens
Interactions: 175
UniProt ID: Q06323

Gene Ontology (top 5):
GO:0000502 - proteasome complex
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0008537 - proteasome activator complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

986867

PSME2
Proteasome activator complex subunit 2

11

4

Small-scale

0.978

High

637395

PSA1
Proteasome subunit alpha type-1

7

16

Small-scale

0.963

High

986785

PSME1
Proteasome activator complex subunit 1

6

4

Small-scale

0.943

High

656110

PSB9
Proteasome subunit beta type-9

5

20

Small-scale

0.927

High

986839

PSB7
Proteasome subunit beta type-7

5

19

Small-scale

0.927

High

832092

PSB2
Proteasome subunit beta type-2

5

20

Small-scale

0.925

High

637676

PSA2
Proteasome subunit alpha type-2

4

18

Small-scale

0.895

High

656451

PSB4
Proteasome subunit beta type-4

4

20

High-throughput

0.895

High

594513

PSB1
Proteasome subunit beta type-1

3

20

High-throughput

0.871

High

831980

PSB3
Proteasome subunit beta type-3

3

20

High-throughput

0.871

High

156276

PSA7
Proteasome subunit alpha type-7

2

16

High-throughput

0.811

High

656208

PSA5
Proteasome subunit alpha type-5

2

15

High-throughput

0.811

High

638116

PSA4
Proteasome subunit alpha type-4

2

19

Small-scale

0.789

High

656591

PSB6
Proteasome subunit beta type-6

2

20

Small-scale

0.789

High

771451

PSB10
Proteasome subunit beta type-10

2

20

Small-scale

0.789

High

893656

PSA6
Proteasome subunit alpha type-6

2

18

Small-scale

0.789

High

656704

PSB5
Proteasome subunit beta type-5

1

20

High-throughput

0.691

High

130860

PSDE
26S proteasome non-ATPase regulatory subunit 14

4

2

Small-scale

0.676

High

986831

PSMG2
Proteasome assembly chaperone 2

3

2

High-throughput

0.675

High

637863

PSA3
Proteasome subunit alpha type-3

1

14

Small-scale

0.618

High

656058

PSB8
Proteasome subunit beta type-8

1

20

Small-scale

0.618

High

874080

PSMD4
26S proteasome non-ATPase regulatory subunit 4

2

1

High-throughput

0.611

High

986798

PSMD6
26S proteasome non-ATPase regulatory subunit 6

2

1

Small-scale

0.611

High

986869

DD19B
ATP-dependent RNA helicase DDX19B

2

1

High-throughput

0.611

High

986875

FBX7
F-box only protein 7

2

2

Small-scale

0.611

High

771504

CTRL
Chymotrypsin-like protease CTRL-1

3

1

High-throughput

0.609

High

893541

SEM1
26S proteasome complex subunit SEM1

2

2

Small-scale

0.601

High

907001

PRS8
26S proteasome regulatory subunit 8

2

3

Small-scale

0.584

High

986801

ADRM1
Proteasomal ubiquitin receptor ADRM1

2

1

Small-scale

0.584

High

108942

H0YKT8
Proteasome subunit beta

1

19

High-throughput

0.575

High

986844

RNF26
E3 ubiquitin-protein ligase RNF26

2

2

High-throughput

0.558

High

496906

TAU
Microtubule-associated protein tau

2

2

High-throughput

0.552

High

843623

FXR1
RNA-binding protein FXR1

1

4

High-throughput

0.541

High

844021

FXR2
RNA-binding protein FXR2

1

4

High-throughput

0.541

High

865035

TTC3
E3 ubiquitin-protein ligase TTC3

1

1

High-throughput

0.541

High

986786

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

1

High-throughput

0.541

High

176437

SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

1

1

High-throughput

0.536

High

198609

PSMD3
26S proteasome non-ATPase regulatory subunit 3

1

1

High-throughput

0.536

High

215742

GTPB6
Putative GTP-binding protein 6

1

1

High-throughput

0.536

High

737761

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

1

High-throughput

0.536

High

782234

NAA10
N-alpha-acetyltransferase 10

1

1

Small-scale

0.536

High

798643

PRS6B
26S proteasome regulatory subunit 6B

1

3

High-throughput

0.536

High

897171

TM258
Transmembrane protein 258

1

1

High-throughput

0.536

High

986814

TTLL5
Tubulin polyglutamylase TTLL5

1

1

High-throughput

0.536

High

986836

NSUN5
28S rRNA

1

1

High-throughput

0.536

High

986837

CDK15
Cyclin-dependent kinase 15

1

1

High-throughput

0.536

High

986842

FANCJ
Fanconi anemia group J protein

1

2

High-throughput

0.536

High

986850

CSR2B
Cysteine-rich protein 2-binding protein

1

2

High-throughput

0.536

High

986854

MBIP1
MAP3K12-binding inhibitory protein 1

1

1

High-throughput

0.536

High

986856

DDX28
Probable ATP-dependent RNA helicase DDX28

1

1

High-throughput

0.536

High

986861

RTEL1
Regulator of telomere elongation helicase 1

1

2

High-throughput

0.536

High

986868

YETS2
YEATS domain-containing protein 2

1

1

High-throughput

0.536

High

986873

LRCH1
Leucine-rich repeat and calponin homology domain-containing protein 1

1

1

High-throughput

0.536

High

838786

EMD
Emerin

1

0

Small-scale

0.529

High

245967

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.518

High

443472

VIME
Vimentin

1

0

High-throughput

0.518

High

575731

VINC
Vinculin

1

0

High-throughput

0.518

High

986872

UBP22
Ubiquitin carboxyl-terminal hydrolase 22

1

0

High-throughput

0.518

High

986855

CXB4
Gap junction beta-4 protein

1

3

High-throughput

0.515

High

156019

RPC1
DNA-directed RNA polymerase III subunit RPC1

1

0

High-throughput

0.513

High

309475

MTMR5
Myotubularin-related protein 5

1

0

High-throughput

0.513

High

830334

KC1E
Casein kinase I isoform epsilon

1

0

High-throughput

0.513

High

897508

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

0

High-throughput

0.513

High

919365

RL23
Large ribosomal subunit protein uL14

1

0

High-throughput

0.513

High

986791

PEX6
Peroxisomal ATPase PEX6

1

0

High-throughput

0.513

High

986797

PSME4
Proteasome activator complex subunit 4

1

0

High-throughput

0.513

High

986805

INAVA
Innate immunity activator protein

1

0

High-throughput

0.513

High

986818

DEN6A
Protein DENND6A

1

0

High-throughput

0.513

High

986821

BBS1
Bardet-Biedl syndrome 1 protein

1

0

High-throughput

0.513

High

986823

FBX30
F-box only protein 30

1

0

High-throughput

0.513

High

986824

P4K2B
Phosphatidylinositol 4-kinase type 2-beta

1

0

High-throughput

0.513

High

986832

SENP5
Sentrin-specific protease 5

1

0

High-throughput

0.513

High

986852

ELP3
Elongator complex protein 3

1

0

High-throughput

0.513

High

986858

RPC5
DNA-directed RNA polymerase III subunit RPC5

1

0

High-throughput

0.513

High

986859

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

0

High-throughput

0.513

High

986862

HOP2
Homologous-pairing protein 2 homolog

1

0

High-throughput

0.513

High

986863

DUX4
Double homeobox protein 4

1

0

High-throughput

0.513

High

986865

TASOR
Protein TASOR

1

0

High-throughput

0.513

High

986866

FBX10
F-box only protein 10

1

0

High-throughput

0.513

High

986871

PSD13
26S proteasome non-ATPase regulatory subunit 13

1

0

High-throughput

0.513

High

986878

SAR1B
Small COPII coat GTPase SAR1B

1

0

High-throughput

0.513

High

986829

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

1

1

High-throughput

0.508

High

394588

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.501

High

413897

GELS
Gelsolin

1

0

High-throughput

0.493

High

986870

UBQL1
Ubiquilin-1

1

0

High-throughput

0.493

High

816572

CXA8
Gap junction alpha-8 protein

1

3

High-throughput

0.489

High

986795

DIP2A
Disco-interacting protein 2 homolog A

1

1

High-throughput

0.489

High

986811

LRCH2
Leucine-rich repeat and calponin homology domain-containing protein 2

1

1

High-throughput

0.489

High

986819

DHX40
Probable ATP-dependent RNA helicase DHX40

1

2

High-throughput

0.489

High

986841

PSMG3
Proteasome assembly chaperone 3

1

1

High-throughput

0.489

High

986851

WDR76
WD repeat-containing protein 76

1

2

High-throughput

0.489

High

303795

RPP14
Ribonuclease P protein subunit p14

1

0

High-throughput

0.486

High

378675

KITH
Thymidine kinase, cytosolic

1

0

High-throughput

0.486

High

393436

AT1B1
Sodium/potassium-transporting ATPase subunit beta-1

1

0

High-throughput

0.486

High

986789

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

0

High-throughput

0.486

High

986800

SETB1
Histone-lysine N-methyltransferase SETDB1

1

0

High-throughput

0.486

High

986802

CDC37
Hsp90 co-chaperone Cdc37

1

0

High-throughput

0.486

High

986803

SMN
Survival motor neuron protein

1

0

High-throughput

0.486

High

933768

TBB4B
Tubulin beta-4B chain

1

1

High-throughput

0.481

High

125398

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

4

High-throughput

0.479

High

227250

PRKN
E3 ubiquitin-protein ligase parkin

1

3

Small-scale

0.479

High

244332

BRD4
Bromodomain-containing protein 4

1

2

High-throughput

0.479

High

294742

RECQ4
ATP-dependent DNA helicase Q4

1

3

High-throughput

0.479

High

324357

BAG3
BAG family molecular chaperone regulator 3

1

2

High-throughput

0.479

High

346602

MYC
Myc proto-oncogene protein

1

2

High-throughput

0.479

High

552561

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.479

High

562554

IL7RA
Interleukin-7 receptor subunit alpha

1

1

High-throughput

0.479

High

569637

CEBPB
CCAAT/enhancer-binding protein beta

1

3

High-throughput

0.479

High

572934

PRS6A
26S proteasome regulatory subunit 6A

1

7

High-throughput

0.479

High

610369

CBL
E3 ubiquitin-protein ligase CBL

1

1

High-throughput

0.479

High

641731

U2AF2
Splicing factor U2AF 65 kDa subunit

1

4

High-throughput

0.479

High

651027

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

799088

NKX21
Homeobox protein Nkx-2.1

1

2

High-throughput

0.479

High

832394

MCM2
DNA replication licensing factor MCM2

1

1

High-throughput

0.479

High

903158

WDR5
WD repeat-containing protein 5

1

1

High-throughput

0.479

High

906817

PRS4
26S proteasome regulatory subunit 4

1

3

Small-scale

0.479

High

908424

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

986792

CUL4A
Cullin-4A

1

1

High-throughput

0.479

High

986799

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

2

High-throughput

0.479

High

986804

MK06
Mitogen-activated protein kinase 6

1

2

High-throughput

0.479

High

986808

AKIR2
Akirin-2

1

1

Small-scale

0.479

High

986812

TET5C
Terminal nucleotidyltransferase 5C

1

1

High-throughput

0.479

High

986813

VIR
Protein virilizer homolog

1

2

High-throughput

0.479

High

986815

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.479

High

986817

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

4

High-throughput

0.479

High

986825

BICD2
Protein bicaudal D homolog 2

1

1

High-throughput

0.479

High

986827

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

4

High-throughput

0.479

High

986835

SCLT1
Sodium channel and clathrin linker 1

1

2

High-throughput

0.479

High

986840

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

1

High-throughput

0.479

High

986846

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

1

1

High-throughput

0.479

High

986848

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.479

High

986849

RMD5A
E3 ubiquitin-protein transferase RMND5A

1

1

High-throughput

0.479

High

986860

PIHD1
PIH1 domain-containing protein 1

1

2

High-throughput

0.479

High

986864

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

986876

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

1

4

Small-scale

0.479

High

609261

FGFR3
Fibroblast growth factor receptor 3

1

2

High-throughput

0.470

High

880904

IF6
Eukaryotic translation initiation factor 6

1

0

High-throughput

0.460

High

299361

UBXN7
UBX domain-containing protein 7

1

0

High-throughput

0.458

High

924504

GRB2
Growth factor receptor-bound protein 2

1

0

High-throughput

0.458

High

986787

TRI26
Tripartite motif-containing protein 26

1

0

Small-scale

0.458

High

986788

REST
RE1-silencing transcription factor

1

0

High-throughput

0.458

High

986816

SEML
Putative protein SEM1, isoform 2

1

0

High-throughput

0.458

High

986793

TBB2A
Tubulin beta-2A chain

1

1

High-throughput

0.457

High

92619

E9PMD8
Proteasome 26S subunit, ATPase 3

1

6

High-throughput

0.445

High

529021

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.445

High

986845

ZDHC5
Palmitoyltransferase ZDHHC5

1

2

High-throughput

0.445

High

986790

CENPR
Centromere protein R

1

0

High-throughput

0.438

High

986830

NEP1
Ribosomal RNA small subunit methyltransferase NEP1

1

0

High-throughput

0.438

High

986853

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.438

High

329668

AGR2
Anterior gradient protein 2 homolog

1

1

High-throughput

0.437

High

986822

DPTOR
DEP domain-containing mTOR-interacting protein

1

1

Small-scale

0.437

High

986874

AAR2
Protein AAR2 homolog

1

2

High-throughput

0.437

High

968567

TAGL
Transgelin

1

0

High-throughput

0.426

High

986807

NCBP3
Nuclear cap-binding protein subunit 3

1

0

High-throughput

0.426

High

831255

CEBPA
CCAAT/enhancer-binding protein alpha

1

3

High-throughput

0.408

High

702

A0A087WW66
26S proteasome non-ATPase regulatory subunit 1

1

1

High-throughput

0.407

High

388878

CP1A1
Cytochrome P450 1A1

2

0

High-throughput

0.318

High

525913

IFM1
Interferon-induced transmembrane protein 1

1

0

High-throughput

0.279

Low

948421

RT06
Small ribosomal subunit protein bS6m

1

0

High-throughput

0.279

Low

986794

NUCG
Endonuclease G, mitochondrial

1

0

High-throughput

0.279

Low

986806

ACSF4
Beta-alanine-activating enzyme

1

0

High-throughput

0.279

Low

986820

PUSL1
tRNA pseudouridine synthase-like 1

1

0

High-throughput

0.279

Low

986828

FIG4
Polyphosphoinositide phosphatase

1

0

High-throughput

0.279

Low

986833

MR1L1
MORF4 family-associated protein 1-like 1

1

0

High-throughput

0.279

Low

986834

DOCK7
Dedicator of cytokinesis protein 7

1

0

High-throughput

0.279

Low

986838

GPX7
Glutathione peroxidase 7

1

0

High-throughput

0.279

Low

986843

TX101
Testis-expressed protein 101

1

0

High-throughput

0.279

Low

986847

VPS11
Vacuolar protein sorting-associated protein 11 homolog

1

0

High-throughput

0.279

Low

986857

ATD3A
ATPase family AAA domain-containing protein 3A

1

0

High-throughput

0.279

Low

986796

NMDE3
Glutamate receptor ionotropic, NMDA 2C

1

0

High-throughput

0.268

Low

986810

TOIP1
Torsin-1A-interacting protein 1

1

0

High-throughput

0.268

Low

986826

JPH3
Junctophilin-3

1

0

High-throughput

0.268

Low

986877

Q9Y649
GW128

1

0

High-throughput

0.268

Low

986809

EMC4
ER membrane protein complex subunit 4

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024