HitPredict

Interactor 1: K22O (Q01546)
Keratin, type II cytoskeletal 2 oral (Cytokeratin-2P) (CK-2P) (K2P) (Keratin-76) (K76) (Type-II keratin Kb9)
Gene: KRT76

Interactor 2: KRT35 (Q92764)
Keratin, type I cuticular Ha5 (Hair keratin, type I Ha5) (Keratin-35) (K35)
Gene: KRT35

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	36949045
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Filament~Filament
Common GO terms	GO:0005829 - cytosol GO:0005882 - intermediate filament GO:0045109 - intermediate filament organization GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 638 Hs			1 455
+	Hs
		280508 K2C8_HUMAN (155-533): 2.09e-168: 491: 63.59		KRT34_HUMAN (48-429): 5.17e-160: 459: 71.32
+	Hs
		409116 K2C8_HUMAN (155-533): 2.09e-168: 491: 63.59		K1C40_HUMAN (19-434): 3.02e-149: 433: 60.82
+	Hs
		359290 K2C8_HUMAN (155-533): 2.09e-168: 491: 63.59		K1C14_HUMAN (95-434): 1.06e-145: 425: 56.77
+	Hs
		408980 K2C8_HUMAN (155-533): 2.09e-168: 491: 63.59		K1C19_HUMAN (89-405): 7.13e-143: 415: 58.04
+	Hs
		409054 K2C8_HUMAN (155-533): 2.09e-168: 491: 63.59		K1C17_HUMAN (90-408): 1.75e-123: 367: 60.82
+	Hs
		280646 K2C78_HUMAN (101-556): 3.14e-131: 397: 55.48		KRT34_HUMAN (48-429): 5.17e-160: 459: 71.32
+	Hs
		408990 K2C8_HUMAN (155-533): 2.09e-168: 491: 63.59		K1C13_HUMAN (91-408): 2.23e-117: 353: 58.93
+	Hs
		409000 K2C8_HUMAN (155-533): 2.09e-168: 491: 63.59		K1C15_HUMAN (96-408): 3.69e-116: 350: 57.96
+	Hs
		49549 K2C8_HUMAN (155-533): 2.09e-168: 491: 63.59		A1A4E9_HUMAN (91-408): 3e-116: 350: 58.31
+	Hs
		408981 K2C8_HUMAN (155-533): 2.09e-168: 491: 63.59		K1C16_HUMAN (93-408): 1.68e-115: 348: 58.86
+	Hs
		409071 K2C8_HUMAN (155-533): 2.09e-168: 491: 63.59		KT33B_HUMAN (56-450): 1.95e-115: 346: 69.67
+	Hs
		444534 K2C7_HUMAN (66-510): 2.56e-144: 429: 58.20		K1C17_HUMAN (90-408): 1.75e-123: 367: 60.82
+	Hs
		409184 K2C8_HUMAN (155-533): 2.09e-168: 491: 63.59		KRT35_HUMAN (1-455): 9.49e-97: 300: 100.00
+	Hs
		280770 K2C8_HUMAN (155-533): 2.09e-168: 491: 63.59		KRT36_HUMAN (1-446): 1.06e-84: 269: 68.39
+	Hs
		409072 K2C8_HUMAN (155-533): 2.09e-168: 491: 63.59		K1H2_HUMAN (1-455): 4.17e-83: 264: 64.40
+	Hs
		280943 K2C8_HUMAN (155-533): 2.09e-168: 491: 63.59		KRT38_HUMAN (24-449): 6.16e-73: 238: 55.63
+	Hs
		280845 K2C8_HUMAN (155-533): 2.09e-168: 491: 63.59		KRT37_HUMAN (24-436): 8.51e-72: 235: 56.90
+	Hs
		409082 K2C8_HUMAN (155-533): 2.09e-168: 491: 63.59		K1H1_HUMAN (49-452): 5.82e-72: 234: 70.94
+	Hs
		280814 K2C78_HUMAN (101-556): 3.14e-131: 397: 55.48		KRT36_HUMAN (1-446): 1.06e-84: 269: 68.39
+	Hs
		280895 K2C78_HUMAN (101-556): 3.14e-131: 397: 55.48		KRT37_HUMAN (24-436): 8.51e-72: 235: 56.90