HitPredict

Interactor 1: EWS (Q01844)
RNA-binding protein EWS (EWS oncogene) (Ewing sarcoma breakpoint region 1 protein)
Gene: EWSR1

Interactor 2: NCOA6 (Q14686)
Nuclear receptor coactivator 6 (Activating signal cointegrator 2) (ASC-2) (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Nuclear receptor-activating protein, 250 kDa) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Thyroid hormone receptor-binding protein)
Gene: NCOA6

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	24999758
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 656 Hs			1 2063
+	Hs
		726818 FUS_HUMAN (55-545): 1.15e-31: 131: 30.35		NCOA6_HUMAN (1-2063): 0: 746: 100.00
+	Hs
		131713 EWS_HUMAN (1-656): 1.54e-47: 179: 100.00		BCL9_HUMAN (109-1440): 4.55e-36: 152: 9.92
+	Hs
		131681 EYA4_HUMAN (3-271): 6.07e-39: 154: 18.02		BCL9_HUMAN (109-1440): 4.55e-36: 152: 9.92
+	Mm
		956882 EYA1_MOUSE (3-277): 2.57e-40: 157: 22.50		SMCA4_MOUSE (351-700): 1.27e-23: 112: 16.81
+	Hs
		820892 EWS_HUMAN (1-656): 1.54e-47: 179: 100.00		PRC2A_HUMAN (208-2062): 5.88e-16: 86.8: 7.66
+	Hs
		967541 EWS_HUMAN (1-656): 1.54e-47: 179: 100.00		PCLO_HUMAN (89-2043): 5.64e-15: 83.7: 7.68
+	Hs
		967173 EWS_HUMAN (1-656): 1.54e-47: 179: 100.00		MDC1_HUMAN (157-945): 1.46e-12: 75.8: 11.15
+	Hs
		318762 EYA4_HUMAN (3-271): 6.07e-39: 154: 18.02		NCOR2_HUMAN (296-2055): 1.78e-19: 98.3: 8.11
+	Hs
		867093 EWS_HUMAN (1-656): 1.54e-47: 179: 100.00		SC24C_HUMAN (219-600): 6.59e-10: 66.7: 20.49
+	Hs
		726649 FUS_HUMAN (55-545): 1.15e-31: 131: 30.35		PRC2A_HUMAN (208-2062): 5.88e-16: 86.8: 7.66
+	Hs
		726939 FUS_HUMAN (55-545): 1.15e-31: 131: 30.35		ARI1B_HUMAN (582-2022): 5.83e-14: 80.2: 10.54
+	Dm
		435986 CO4A1_DROME (378-655): 1.52e-22: 105: 15.68		Q9VLS7_DROME (1052-2062): 6.68e-21: 102: 9.01
+	Hs
		726817 FUS_HUMAN (55-545): 1.15e-31: 131: 30.35		MDC1_HUMAN (157-945): 1.46e-12: 75.8: 11.15
+	Hs
		118625 EYA2_HUMAN (27-278): 1.48e-18: 91.3: 20.16		NCOR2_HUMAN (296-2055): 1.78e-19: 98.3: 8.11
+	Dm
		1370237 Q9VMV5_DROME (3-357): 2.61e-15: 82.2: 12.08		Q9VLS7_DROME (1052-2062): 6.68e-21: 102: 9.01
+	Dm
		1371011 Q9VMV5_DROME (3-357): 2.61e-15: 82.2: 12.08		Q9VTR6_DROME (382-1899): 5.43e-19: 97: 10.94
+	Hs
		118581 EYA2_HUMAN (27-278): 1.48e-18: 91.3: 20.16		ARI1B_HUMAN (582-2022): 5.83e-14: 80.2: 10.54