Protein: THUM3
tRNA (guanine(6)-N(2))-methyltransferase THUMP3 (EC 2.1.1.256) (THUMP domain-containing protein 3) (tRNA(Trp) (guanine(7)-N(2))-methyltransferase THUMP3) (EC 2.1.1.-)

Gene: THUM3, THUMPD3
Organism: Homo sapiens
Interactions: 89
UniProt ID: Q9BV44

Gene Ontology (top 5):
GO:0000049 - tRNA binding
GO:0005730 - nucleolus
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0016423 - tRNA (guanine) methyltransferase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1414907

TR112
Multifunctional methyltransferase subunit TRM112-like protein

6

3

Small-scale

0.946

High

1386853

ZN501
Zinc finger protein 501

3

0

High-throughput

0.638

High

290980

PPM1B
Protein phosphatase 1B

3

0

High-throughput

0.634

High

1360892

ACO11
Acyl-coenzyme A thioesterase 11

3

0

High-throughput

0.634

High

1414899

NSUN3
tRNA

3

0

High-throughput

0.634

High

1414910

PUS1
Pseudouridylate synthase 1 homolog

3

0

High-throughput

0.634

High

967175

UBP46
Ubiquitin carboxyl-terminal hydrolase 46

2

1

High-throughput

0.628

High

1280969

CTU1
Cytoplasmic tRNA 2-thiolation protein 1

2

1

High-throughput

0.628

High

1409705

MICU1
Calcium uptake protein 1, mitochondrial

3

1

High-throughput

0.604

High

277470

AVIL
Advillin

2

0

High-throughput

0.602

High

289811

MTU1
Mitochondrial tRNA-specific 2-thiouridylase 1

2

0

High-throughput

0.602

High

900487

FXR2
RNA-binding protein FXR2

2

0

High-throughput

0.602

High

1180695

CTU2
Cytoplasmic tRNA 2-thiolation protein 2

2

0

High-throughput

0.602

High

1414901

LN28A
Protein lin-28 homolog A

2

2

High-throughput

0.601

High

1087525

GRSF1
G-rich sequence factor 1

2

2

High-throughput

0.584

High

1335490

SEN2
tRNA-splicing endonuclease subunit Sen2

2

0

High-throughput

0.576

High

1239378

ESRP1
Epithelial splicing regulatory protein 1

2

2

High-throughput

0.574

High

1293585

MICU3
Calcium uptake protein 3, mitochondrial

2

1

High-throughput

0.574

High

242782

PRKN
E3 ubiquitin-protein ligase parkin

2

0

High-throughput

0.559

High

259083

DNJA2
DnaJ homolog subfamily A member 2

1

1

High-throughput

0.536

High

169316

LECT2
Leukocyte cell-derived chemotaxin-2

1

0

High-throughput

0.513

High

296822

ST1C4
Sulfotransferase 1C4

1

0

High-throughput

0.513

High

298222

DCTN3
Dynactin subunit 3

1

0

High-throughput

0.513

High

652402

TGM1
Protein-glutamine gamma-glutamyltransferase K

1

0

High-throughput

0.513

High

1023281

RBM3
RNA-binding protein 3

1

0

High-throughput

0.513

High

1110554

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

1

0

High-throughput

0.513

High

1355890

GRK7
Rhodopsin kinase GRK7

1

0

High-throughput

0.513

High

1383836

EFMT3
EEF1A lysine methyltransferase 3

1

0

High-throughput

0.513

High

1414898

CIA2A
Cytosolic iron-sulfur assembly component 2A

1

0

High-throughput

0.513

High

1414903

ABC3C
DNA dC->dU-editing enzyme APOBEC-3C

1

0

High-throughput

0.513

High

1414908

CTND2
Catenin delta-2

1

0

High-throughput

0.513

High

1052909

HME1
Homeobox protein engrailed-1

1

1

High-throughput

0.489

High

315962

RECQ4
ATP-dependent DNA helicase Q4

1

2

High-throughput

0.479

High

1131116

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

2

High-throughput

0.479

High

1255337

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.479

High

1414897

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.479

High

1414906

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

141641

DDX3X
ATP-dependent RNA helicase DDX3X

1

0

High-throughput

0.458

High

346269

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

373030

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

831350

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

1095781

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

0

High-throughput

0.458

High

1135797

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.458

High

1146469

KS6A2
Ribosomal protein S6 kinase alpha-2

1

0

High-throughput

0.458

High

1280462

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

0

High-throughput

0.458

High

1414900

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

1414904

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

0

High-throughput

0.458

High

275918

UBP12
Ubiquitin carboxyl-terminal hydrolase 12

1

1

High-throughput

0.445

High

1099227

SRSF5
Serine/arginine-rich splicing factor 5

1

1

High-throughput

0.445

High

1148773

RBMS2
RNA-binding motif, single-stranded-interacting protein 2

1

2

High-throughput

0.445

High

1251038

RBMS3
RNA-binding motif, single-stranded-interacting protein 3

1

2

High-throughput

0.445

High

1252507

LN28B
Protein lin-28 homolog B

1

2

High-throughput

0.445

High

1347149

WDR48
WD repeat-containing protein 48

1

1

High-throughput

0.445

High

1414909

YBOX2
Y-box-binding protein 2

1

2

High-throughput

0.445

High

696388

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.437

High

985314

RL10A
Large ribosomal subunit protein uL1

1

0

High-throughput

0.426

High

1209603

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

1280126

SEN54
tRNA-splicing endonuclease subunit Sen54

1

0

High-throughput

0.426

High

1290479

IQGA3
Ras GTPase-activating-like protein IQGAP3

1

0

High-throughput

0.426

High

1349267

WDR20
WD repeat-containing protein 20

1

0

High-throughput

0.426

High

1380392

I22R2
Interleukin-22 receptor subunit alpha-2

1

0

High-throughput

0.426

High

1414902

SPHK2
Sphingosine kinase 2

1

0

High-throughput

0.426

High

1185220

EDRF1
Erythroid differentiation-related factor 1

2

0

High-throughput

0.328

High

225216

GATC
Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial

1

0

High-throughput

0.279

Low

1009304

PRR3
Proline-rich protein 3

1

0

High-throughput

0.279

Low

1101304

SLAF1
Signaling lymphocytic activation molecule

1

0

High-throughput

0.279

Low

1153482

EFNB3
Ephrin-B3

1

0

High-throughput

0.279

Low

1325832

D2HDH
D-2-hydroxyglutarate dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

1385975

ZN653
Zinc finger protein 653

1

0

High-throughput

0.279

Low

1402702

TCPQM
T-complex protein 1 subunit theta-like 2

1

0

High-throughput

0.279

Low

1414894

ADA19
Disintegrin and metalloproteinase domain-containing protein 19

1

0

High-throughput

0.279

Low

1414896

GTSFL
Gametocyte-specific factor 1-like

1

0

High-throughput

0.279

Low

1414905

UGGG2
UDP-glucose:glycoprotein glucosyltransferase 2

1

0

High-throughput

0.279

Low

344568

LSM8
U6 snRNA-associated Sm-like protein LSm8

1

0

High-throughput

0.265

Low

412541

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.249

Low

567970

PRG2
Bone marrow proteoglycan

1

0

High-throughput

0.249

Low

589577

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

838952

RHG25
Rho GTPase-activating protein 25

1

0

High-throughput

0.249

Low

1058629

CKAP4
Cytoskeleton-associated protein 4

1

0

High-throughput

0.249

Low

1100321

TIF1B
Transcription intermediary factor 1-beta

1

0

High-throughput

0.249

Low

1383664

VP33A
Vacuolar protein sorting-associated protein 33A

1

0

High-throughput

0.249

Low

1389315

T3HPD
Trans-3-hydroxy-L-proline dehydratase

1

0

High-throughput

0.249

Low

388797

C1QC
Complement C1q subcomponent subunit C

1

0

High-throughput

0.232

Low

517310

GAGE1
G antigen 1

1

0

High-throughput

0.232

Low

1203519

S45A4
Solute carrier family 45 member 4

1

0

High-throughput

0.232

Low

1254189

MFSD6
Major facilitator superfamily domain-containing protein 6

1

0

High-throughput

0.232

Low

1288157

SL9B2
Sodium/hydrogen exchanger 9B2

1

0

High-throughput

0.232

Low

1402439

CCNL2
Cyclin-L2

1

0

High-throughput

0.232

Low

1414895

MAGT1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025