Protein: UBP12
Ubiquitin carboxyl-terminal hydrolase 12 (EC 3.4.19.12) (Deubiquitinating enzyme 12) (Ubiquitin specific peptidase 12) (Ubiquitin thioesterase 12) (Ubiquitin-hydrolyzing enzyme 1) (Ubiquitin-specific-processing protease 12)

Gene: UBP12, USP12
Organism: Homo sapiens
Interactions: 71
UniProt ID: O75317

Gene Ontology (top 5):
GO:0004197 - cysteine-type endopeptidase activity
GO:0004843 - cysteine-type deubiquitinase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

275905

WDR48
WD repeat-containing protein 48

11

11

Small-scale

0.976

High

275906

WDR20
WD repeat-containing protein 20

12

16

Small-scale

0.976

High

275882

UBP46
Ubiquitin carboxyl-terminal hydrolase 46

4

12

Small-scale

0.881

High

275888

DMWD
Dystrophia myotonica WD repeat-containing protein

3

17

Small-scale

0.847

High

247191

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

4

5

Small-scale

0.697

High

275922

VSX1
Visual system homeobox 1

4

3

High-throughput

0.694

High

275896

UBP39
Ubiquitin carboxyl-terminal hydrolase 39

1

17

High-throughput

0.691

High

275880

VSX2
Visual system homeobox 2

3

3

High-throughput

0.667

High

275901

PHLP2
PH domain leucine-rich repeat-containing protein phosphatase 2

3

5

Small-scale

0.667

High

275904

TSYL6
Testis-specific Y-encoded-like protein 6

3

5

High-throughput

0.662

High

275867

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

20

Small-scale

0.647

High

275868

ANDR
Androgen receptor

3

9

Small-scale

0.640

High

275900

RN19B
E3 ubiquitin-protein ligase RNF19B

2

8

High-throughput

0.628

High

275911

R51A1
RAD51-associated protein 1

2

1

High-throughput

0.628

High

275915

GORS1
Golgi reassembly-stacking protein 1

2

1

High-throughput

0.628

High

275862

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

15

High-throughput

0.618

High

275914

MEP50
Methylosome protein WDR77

1

9

Small-scale

0.618

High

275920

WDR26
WD repeat-containing protein 26

1

10

Small-scale

0.618

High

275916

HSPB9
Heat shock protein beta-9

2

0

High-throughput

0.602

High

275874

1433B
14-3-3 protein beta/alpha

2

20

High-throughput

0.601

High

275881

1433G
14-3-3 protein gamma

2

20

High-throughput

0.601

High

275886

1433F
14-3-3 protein eta

2

20

High-throughput

0.601

High

275897

SGO1
Shugoshin 1

2

1

High-throughput

0.601

High

275912

ITCH
E3 ubiquitin-protein ligase Itchy homolog

2

4

Small-scale

0.584

High

275903

GP161
G-protein coupled receptor 161

2

1

High-throughput

0.574

High

275887

BAX
Apoptosis regulator BAX

1

1

Small-scale

0.573

High

275866

HMGB1
High mobility group protein B1

1

1

Small-scale

0.561

High

275873

RIR2
Ribonucleoside-diphosphate reductase subunit M2

1

0

Small-scale

0.537

High

275865

MMP2
72 kDa type IV collagenase

1

2

High-throughput

0.536

High

275872

CD6
T-cell differentiation antigen CD6

1

1

High-throughput

0.536

High

275893

DHX8
ATP-dependent RNA helicase DHX8

1

5

High-throughput

0.536

High

275908

IGDC4
Immunoglobulin superfamily DCC subclass member 4

1

1

High-throughput

0.536

High

275913

OPALI
Opalin

1

1

High-throughput

0.536

High

275917

CAB45
45 kDa calcium-binding protein

1

2

High-throughput

0.536

High

275919

PAIP1
Polyadenylate-binding protein-interacting protein 1

1

2

High-throughput

0.536

High

275924

HSPB8
Heat shock protein beta-8

1

1

High-throughput

0.536

High

275926

PHF8
Histone lysine demethylase PHF8

1

2

High-throughput

0.536

High

275927

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

1

6

High-throughput

0.536

High

275891

ILF3
Interleukin enhancer-binding factor 3

1

6

High-throughput

0.515

High

275875

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

1

High-throughput

0.515

High

275907

NEK7
Serine/threonine-protein kinase Nek7

1

6

High-throughput

0.515

High

275909

Q8WUW6
DMWD protein

1

7

High-throughput

0.514

High

275884

X3CL1
Fractalkine

1

0

High-throughput

0.513

High

275890

NU160
Nuclear pore complex protein Nup160

1

0

High-throughput

0.513

High

275898

CDC73
Parafibromin

1

0

Small-scale

0.504

High

275864

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.501

High

275877

NOTC1
Neurogenic locus notch homolog protein 1

1

7

Small-scale

0.501

High

275894

H2A2C
Histone H2A type 2-C

1

14

Small-scale

0.501

High

275895

H2B2E
Histone H2B type 2-E

1

16

Small-scale

0.501

High

275870

CALR
Calreticulin

1

0

High-throughput

0.493

High

275925

PNMA2
Paraneoplastic antigen Ma2

1

2

High-throughput

0.489

High

270864

CLAP2
CLIP-associating protein 2

1

2

High-throughput

0.479

High

275863

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

4

High-throughput

0.479

High

275871

EPHA2
Ephrin type-A receptor 2

1

2

High-throughput

0.479

High

275876

ZAP70
Tyrosine-protein kinase ZAP-70

1

8

Small-scale

0.479

High

275878

MMP14
Matrix metalloproteinase-14

1

2

Small-scale

0.479

High

275879

MECP2
Methyl-CpG-binding protein 2

1

3

High-throughput

0.479

High

275883

GRB2
Growth factor receptor-bound protein 2

1

6

Small-scale

0.479

High

275885

MDM2
E3 ubiquitin-protein ligase Mdm2

1

5

Small-scale

0.479

High

275889

EP300
Histone acetyltransferase p300

1

3

Small-scale

0.479

High

275892

CBLB
E3 ubiquitin-protein ligase CBL-B

1

4

Small-scale

0.479

High

275910

DCAF4
DDB1- and CUL4-associated factor 4

1

1

High-throughput

0.479

High

220326

LAT
Linker for activation of T-cells family member 1

1

0

Small-scale

0.458

High

275861

PPM1B
Protein phosphatase 1B

1

0

Small-scale

0.458

High

275899

TRAT1
T-cell receptor-associated transmembrane adapter 1

1

0

Small-scale

0.458

High

275921

NMRL1
NmrA-like family domain-containing protein 1

1

0

High-throughput

0.458

High

258679

DNJA2
DnaJ homolog subfamily A member 2

1

6

High-throughput

0.445

High

275918

THUM3
tRNA

1

1

High-throughput

0.445

High

275902

MAVS
Mitochondrial antiviral-signaling protein

1

3

Small-scale

0.437

High

275923

Q9P1S2
HDCMD34P

1

3

High-throughput

0.407

High

275869

MK
Midkine

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025