HitPredict

Interactor 1: OCRL (Q01968)
Inositol polyphosphate 5-phosphatase OCRL (EC 3.1.3.36) (EC 3.1.3.56) (Inositol polyphosphate 5-phosphatase OCRL-1) (OCRL-1) (Lowe oculocerebrorenal syndrome protein) (Phosphatidylinositol 3,4,5-triphosphate 5-phosphatase) (EC 3.1.3.86)
Gene: OCRL

Interactor 2: RAB6B (Q9NRW1)
Ras-related protein Rab-6B (EC 3.6.5.2)
Gene: RAB6B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.79	1.00	0.892

Property	Details
Experiments	32203420, 28514442, 33961781, unassigned2213
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ras~RhoGAP
Common GO terms	GO:0005829 - cytosol
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 901 Hs			1 208
+	Hs
		592207 OCRL_HUMAN (1-901): 0: 1075: 100.00		RAB5A_HUMAN (3-207): 4.67e-89: 262: 40.78
+	Hs
		844489 OCRL_HUMAN (1-901): 0: 1075: 100.00		RAB5C_HUMAN (3-207): 3.56e-89: 262: 40.98
+	Hs
		918850 OCRL_HUMAN (1-901): 0: 1075: 100.00		RAB1A_HUMAN (1-207): 7.26e-89: 261: 34.30
+	Hs
		968218 OCRL_HUMAN (1-901): 0: 1075: 100.00		RAB1B_HUMAN (7-206): 1.58e-87: 258: 35.50
+	Hs
		592651 OCRL_HUMAN (1-901): 0: 1075: 100.00		RAB6A_HUMAN (1-208): 1.37e-84: 250: 90.87
+	Hs
		914016 OCRL_HUMAN (1-901): 0: 1075: 100.00		RB11A_HUMAN (7-206): 6.52e-84: 249: 28.71
+	Hs
		968196 OCRL_HUMAN (1-901): 0: 1075: 100.00		RAB1C_HUMAN (7-206): 2.98e-84: 249: 35.00
+	Rn
		112176 R9PXS2_RAT (14-901): 0: 1038: 93.81		RAB5A_RAT (3-207): 4.83e-89: 262: 41.26
+	Rn
		1157320 R9PXS2_RAT (14-901): 0: 1038: 93.81		RAB1A_RAT (1-207): 7.26e-89: 261: 34.30
+	Rn
		1376736 R9PXS2_RAT (14-901): 0: 1038: 93.81		RAB6A_RAT (1-208): 9.38e-85: 251: 90.87
+	Hs
		895348 OCRL_HUMAN (1-901): 0: 1075: 100.00		RAB5B_HUMAN (13-178): 5.66e-49: 160: 45.78
+	Hs
		968138 OCRL_HUMAN (1-901): 0: 1075: 100.00		RAB31_HUMAN (11-196): 5.59e-45: 149: 36.56
+	Hs
		592125 I5P2_HUMAN (143-897): 0: 719: 50.27		RAB5A_HUMAN (3-207): 4.67e-89: 262: 40.78
+	Dm
		185584 O46094_DROME (209-900): 1.12e-177: 537: 33.15		RAB6_DROME (1-208): 7.05e-90: 264: 84.21
+	Dm
		185463 O46094_DROME (209-900): 1.12e-177: 537: 33.15		O18332_DROME (1-207): 2.15e-86: 255: 34.30
+	Dm
		220979 O46094_DROME (209-900): 1.12e-177: 537: 33.15		RAB5_DROME (13-175): 6.17e-49: 160: 45.40
+	Dm
		185619 Q95R90_DROME (380-900): 5.7e-116: 365: 32.27		RAB6_DROME (1-208): 7.05e-90: 264: 84.21