HitPredict

Interactor 1: NRG1 (Q02297)
Pro-neuregulin-1, membrane-bound isoform (Pro-NRG1) [Cleaved into: Neuregulin-1 (Acetylcholine receptor-inducing activity) (ARIA) (Breast cancer cell differentiation factor p45) (Glial growth factor) (Heregulin) (HRG) (Neu differentiation factor) (Sensory and motor neuron-derived factor)]
Gene: NRG1

Interactor 2: TMTC4 (Q5T4D3)
Protein O-mannosyl-transferase TMTC4 (EC 2.4.1.109) (Transmembrane O-mannosyltransferase targeting cadherins 4) (Transmembrane and tetratricopeptide repeat-containing 4)
Gene: TMTC4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	EGF~TPR_16, EGF~TPR_8
Common GO terms	GO:0016020 - membrane
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1 640 Hs			1 741
+	Hs
		970273 NRG1_HUMAN (1-640): 3.51e-172: 506: 100.00		TMTC3_HUMAN (397-733): 1.72e-44: 174: 17.14
+	Hs
		684921 TITIN_HUMAN (19-217): 1.22e-10: 67.4: 11.33		STIP1_HUMAN (655-739): 5.43e-09: 61.2: 14.12