HitPredict

Interactor 1: ID2 (Q02363)
DNA-binding protein inhibitor ID-2 (Class B basic helix-loop-helix protein 26) (bHLHb26) (Inhibitor of DNA binding 2) (Inhibitor of differentiation 2)
Gene: ID2

Interactor 2: ASCL4 (Q6XD76)
Achaete-scute homolog 4 (ASH-4) (hASH4) (Achaete-scute-like protein 4) (Class A basic helix-loop-helix protein 44) (bHLHa44)
Gene: ASCL4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.73	1.00	0.858

Property	Details
Experiments	32296183, 33961781, unassigned1304
Identification Methods	two hybrid, affinity chromatography technology, validated two hybrid, two hybrid array, two hybrid prey pooling approach, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	HLH~HLH
Common GO terms	GO:0006357 - regulation of transcription by RNA polymerase II GO:0046983 - protein dimerization activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 134 Hs			1 172
+	Mm
		485939 ID2_MOUSE (1-134): 1.14e-70: 209: 98.51		MYOD1_MOUSE (5-166): 6.04e-30: 113: 28.14
+	Hs
		545958 ID2_HUMAN (1-134): 1.82e-70: 209: 100.00		MYOD1_HUMAN (5-166): 5.86e-28: 107: 27.98
+	Hs
		526743 ID2_HUMAN (1-134): 1.82e-70: 209: 100.00		MYF5_HUMAN (21-168): 9.52e-28: 105: 23.90
+	Mm
		781010 ID2_MOUSE (1-134): 1.14e-70: 209: 98.51		OLIG2_MOUSE (1-158): 4.26e-26: 103: 18.13
+	Hs
		780971 ID1_HUMAN (14-133): 1.58e-45: 146: 45.39		ASCL4_HUMAN (1-156): 7.3e-41: 137: 100.00
+	Mm
		485951 Q6GTZ3_MOUSE (15-133): 8.44e-45: 144: 46.83		MYOD1_MOUSE (5-166): 6.04e-30: 113: 28.14
+	Hs
		780989 ID1_HUMAN (14-133): 1.58e-45: 146: 45.39		ASCL3_HUMAN (5-155): 1.02e-29: 108: 37.74
+	Hs
		545945 ID1_HUMAN (14-133): 1.58e-45: 146: 45.39		MYOD1_HUMAN (5-166): 5.86e-28: 107: 27.98
+	Hs
		526742 ID1_HUMAN (14-133): 1.58e-45: 146: 45.39		MYF5_HUMAN (21-168): 9.52e-28: 105: 23.90
+	Hs
		524547 ID1_HUMAN (14-133): 1.58e-45: 146: 45.39		LYL1_HUMAN (55-168): 6.19e-27: 104: 30.23
+	Mm
		485938 ID3_MOUSE (1-133): 1.2e-41: 135: 38.41		MYOD1_MOUSE (5-166): 6.04e-30: 113: 28.14
+	Hs
		545959 ID3_HUMAN (1-133): 8.38e-44: 141: 39.13		MYOD1_HUMAN (5-166): 5.86e-28: 107: 27.98
+	Hs
		546071 ID1_HUMAN (14-133): 1.58e-45: 146: 45.39		MYOG_HUMAN (12-167): 1.65e-26: 101: 23.72
+	Hs
		526744 ID3_HUMAN (1-133): 8.38e-44: 141: 39.13		MYF5_HUMAN (21-168): 9.52e-28: 105: 23.90
+	Hs
		524557 ID3_HUMAN (1-133): 8.38e-44: 141: 39.13		LYL1_HUMAN (55-168): 6.19e-27: 104: 30.23
+	Hs
		780960 ID1_HUMAN (14-133): 1.58e-45: 146: 45.39		HEN2_HUMAN (1-129): 3.36e-26: 98.4: 25.37
+	Hs
		524549 ID4_HUMAN (33-109): 7.03e-31: 109: 54.12		LYL1_HUMAN (55-168): 6.19e-27: 104: 30.23
+	Hs
		546072 ID4_HUMAN (33-109): 7.03e-31: 109: 54.12		MYOG_HUMAN (12-167): 1.65e-26: 101: 23.72
+	Hs
		568188 ID4_HUMAN (33-109): 7.03e-31: 109: 54.12		TAL1_HUMAN (57-161): 7.57e-22: 91.5: 30.28
+	Mm
		589139 ID1_MOUSE (15-123): 2.97e-41: 136: 50.00		TAL1_MOUSE (56-131): 2.67e-10: 59.5: 36.25