HitPredict

Interactor 1: FKBP4 (Q02790)
Peptidyl-prolyl cis-trans isomerase FKBP4 (PPIase FKBP4) (EC 5.2.1.8) (51 kDa FK506-binding protein) (FKBP51) (52 kDa FK506-binding protein) (52 kDa FKBP) (FKBP-52) (59 kDa immunophilin) (p59) (FK506-binding protein 4) (FKBP-4) (FKBP59) (HSP-binding immunophilin) (HBI) (Immunophilin FKBP52) (Rotamase) [Cleaved into: Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed]
Gene: FKBP4

Interactor 2: AGO2 (Q9UKV8)
Protein argonaute-2 (Argonaute2) (hAgo2) (EC 3.1.26.n2) (Argonaute RISC catalytic component 2) (Eukaryotic translation initiation factor 2C 2) (eIF-2C 2) (eIF2C 2) (PAZ Piwi domain protein) (PPD) (Protein slicer)
Gene: AGO2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	29395067, 23741051
Identification Methods	proximity labelling technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 459 Hs			1 859
+	Mm
		1145401 FKBP5_MOUSE (1-451): 1.47e-136: 402: 53.66		AGO2_MOUSE (1-859): 0: 1219: 99.19
+	Hs
		1035042 FKBP5_HUMAN (1-456): 2.91e-138: 406: 54.83		AGO2_HUMAN (1-859): 0: 1205: 100.00
+	Hs
		1035043 FKBP5_HUMAN (1-456): 2.91e-138: 406: 54.83		AGO1_HUMAN (17-859): 0: 1182: 83.16
+	Hs
		1035002 FKBP5_HUMAN (1-456): 2.91e-138: 406: 54.83		AGO3_HUMAN (5-859): 0: 1165: 79.75
+	Hs
		1035009 FKBP5_HUMAN (1-456): 2.91e-138: 406: 54.83		AGO4_HUMAN (16-859): 0: 1145: 78.51
+	Hs
		59978 FKBP5_HUMAN (1-456): 2.91e-138: 406: 54.83		A4FVC0_HUMAN (72-859): 0: 1130: 100.00
+	Dm
		1103850 FKB59_DROME (21-450): 5.99e-129: 382: 43.02		Q32KD4_DROME (6-859): 0: 1136: 73.10
+	Hs
		118802 AIP_HUMAN (146-416): 1.8e-50: 176: 20.12		AGO1_HUMAN (17-859): 0: 1182: 83.16
+	Hs
		1034966 FKBP5_HUMAN (1-456): 2.91e-138: 406: 54.83		PIWL1_HUMAN (23-826): 0: 751: 22.45
+	Hs
		1034939 FKBP5_HUMAN (1-456): 2.91e-138: 406: 54.83		PIWL2_HUMAN (5-821): 0: 735: 21.74
+	Hs
		1034913 FKBP5_HUMAN (1-456): 2.91e-138: 406: 54.83		PIWL4_HUMAN (22-822): 0: 686: 22.07
+	Dm
		1186010 FKB59_DROME (21-450): 5.99e-129: 382: 43.02		AGO3_DROME (31-826): 0: 638: 20.89
+	Hs
		259953 FKBP6_HUMAN (5-144): 9.96e-35: 133: 32.62		PIWL4_HUMAN (22-822): 0: 686: 22.07
+	Hs
		684905 STIP1_HUMAN (259-458): 6.41e-12: 69.5: 11.51		PIWL2_HUMAN (5-821): 0: 735: 21.74