HitPredict

Interactor 1: CACT (Q03017)
NF-kappa-B inhibitor cactus
Gene: CACT

Interactor 2: NFKB1 (Q94527)
Nuclear factor NF-kappa-B p110 subunit (Rel-p110) (Relish protein) [Cleaved into: Nuclear factor NF-kappa-B p68 subunit (Rel-p68); Nuclear factor NF-kappa-B p49 subunit (Rel-p49)]
Gene: Rel

Species: Drosophila melanogaster

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.807

Property	Details
Experiments	22654665, 12653959
Identification Methods	pull down, affinity chromatography technology, two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Ank~Ank_2, Ank~RHD_dimer, Ank_2~Ank_2, Ank_2~RHD_dimer
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 500 Dm			1 971
+	Hs
		587527 NFKB2_HUMAN (196-477): 3.42e-66: 231: 29.00		NFKB1_HUMAN (112-965): 2.04e-146: 461: 22.83
+	Mm
		638473 NFKB2_MOUSE (196-478): 2e-64: 226: 28.57		NFKB1_MOUSE (113-965): 2.36e-147: 464: 22.71
+	Hs
		961363 NFKB2_HUMAN (196-477): 3.42e-66: 231: 29.00		NFKB2_HUMAN (142-970): 2.2e-144: 454: 22.12
+	Dm
		957297 CACT_DROME (1-500): 5.15e-91: 288: 100.00		DIF_DROME (115-487): 3.74e-89: 300: 30.05
+	Dm
		547613 CACT_DROME (1-500): 5.15e-91: 288: 100.00		DORS_DROME (142-446): 6.19e-79: 279: 35.92
+	Hs
		961365 NFKB2_HUMAN (196-477): 3.42e-66: 231: 29.00		RELB_HUMAN (27-508): 3.62e-95: 314: 24.13
+	Mm
		981549 NFKB2_MOUSE (196-478): 2e-64: 226: 28.57		RELB_MOUSE (74-502): 1.02e-85: 288: 26.15
+	Hs
		961369 NFKB2_HUMAN (196-477): 3.42e-66: 231: 29.00		REL_HUMAN (143-576): 1.62e-81: 278: 25.33
+	Hs
		961368 NFKB2_HUMAN (196-477): 3.42e-66: 231: 29.00		TF65_HUMAN (140-512): 2.04e-81: 276: 27.85
+	Mm
		978989 NFKB2_MOUSE (196-478): 2e-64: 226: 28.57		TF65_MOUSE (140-673): 4.07e-82: 278: 22.31
+	Xl
		981811 Q6DCW3_XENLA (227-452): 5.19e-67: 219: 35.68		TF65_XENLA (134-569): 3.02e-80: 272: 27.29
+	Hs
		1021462 ANK3_HUMAN (21-415): 1.93e-61: 220: 14.79		Q9H4D1_HUMAN (341-888): 7.61e-76: 267: 15.47
+	Hs
		883496 ANK3_HUMAN (21-415): 1.93e-61: 220: 14.79		RIPK4_HUMAN (341-888): 1.63e-71: 255: 14.57
+	Hs
		1206016 MIB2_HUMAN (111-496): 3.08e-66: 232: 18.11		MIB1_HUMAN (421-905): 6.31e-38: 155: 15.17
+	Hs
		167036 ANR50_HUMAN (109-500): 1.96e-74: 257: 16.25		ANR28_HUMAN (211-694): 4.56e-28: 124: 7.79
+	Hs
		166919 ANK3_HUMAN (21-415): 1.93e-61: 220: 14.79		ANR28_HUMAN (211-694): 4.56e-28: 124: 7.79
+	Hs
		1216596 ANR50_HUMAN (109-500): 1.96e-74: 257: 16.25		ZDH17_HUMAN (621-811): 9.86e-11: 67.8: 26.43
+	Hs
		1216507 Q8TB46_HUMAN (174-500): 3.28e-75: 253: 17.30		ZDH17_HUMAN (621-811): 9.86e-11: 67.8: 26.43
+	Hs
		639729 NFKB2_HUMAN (196-477): 3.42e-66: 231: 29.00		IKBA_HUMAN (671-831): 1.32e-17: 86.7: 24.07
+	Hs
		121583 NFKB2_HUMAN (196-477): 3.42e-66: 231: 29.00		IKBE_HUMAN (667-811): 1.25e-09: 64: 19.05